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Inhibitors of the Release of Anaphylactic Mediators

  • Chapter
Anti-Inflammatory Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 50 / 2))

Abstract

Cromoglycate inhibits a number of allergic reactions and in particular the allergen-induced bronchospasm in patients with extrinsic asthma; clinical findings which are outside the scope of this chapter have been reviewed by Pepys (1973) and Brogden et al. (1974). Laboratory studies revealed that this compound was neither a bronchodilator nor an antagonist of histamine, 5-hydroxytryptamine (5-HT) nor slow reacting substance of anaphylaxis (SRS-A), the suspected mediators of allergic bronchospasm, but rather prevented the anaphylactic release of these mediators (Cox, 1967; Cox et al., 1970). Lymphocyte functions correlated with the cell-mediated immune response were not inhibited by the drug (Walker and Dolby, 1975). In animals and man, cromoglycate inhibits immediate hypersensitivity reactions provoked by several different antigens, suggesting that it does not act by blocking the antibody receptor for antigen. This has been confirmed by Orr et al. (1970 a) in studies using double sensitization with two antigenically distinct rat reagins. Furthermore, since the compound is effective in passively sensitized tissues, and in clinical usage does not reduce serum IgE levels (Berg and Johansson, 1971), it does not act by inhibiting antibody production. These observations, together with results described in detail in later sections, suggest that an important part of the clinical efficacy of cromoglycate may be attributed to prevention of exocytosis in mast cells.

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References

  • Altounyan, R.E.C.: Inhibition of experimental asthma by a new compound-disodium cromoglycate “Intal”. Acta allerg. (Kbh.) 22, 487 (1967)

    Google Scholar 

  • Amundsen, E., Ofstad, E., Hagen, P.-O.: Histamine release induced by synergistic action of kallikrein and phospholipase A. Arch. int. Pharmacodyn. 178, 104–114 (1969)

    PubMed  CAS  Google Scholar 

  • Anderson, P., Slorach, S.A., Uvnäs, B.: Sequential exocytosis of storage granules during antigen-induced histamine release from sensitized rat mast cells in vitro. An electron microscopic study. Acta physiol. scand. 88, 359–372 (1973)

    PubMed  CAS  Google Scholar 

  • Ankier, S.I.: Disodium cromoglycate and inhibition of passive cutaneous anaphylaxis. Int. Arch. Allergy 41,163–165(1971)

    Google Scholar 

  • Ankier, S.I., Neat, M.L.: Some studies on acute inflammation induced by dextran in the mouse. Int. Arch. Allergy 42, 264–277 (1972)

    PubMed  CAS  Google Scholar 

  • Ashton, M. J., Clark, B., Jones, K.M., Moss, G.F., Neale, M.G., Ritchie, J.T.: The absorption, metabolism, and excretion of disodium cromoglycate in nine animal species. Toxicol. appl. Pharmacol. 26, 319–328 (1973)

    PubMed  CAS  Google Scholar 

  • Assem, E.S.K.: Inhibition of allergic reactions by cromoglycate and by a new series of compounds (AH 6556, AH 7079, and AH 7725). Int. Arch. Allergy 45, 708–718 (1973)

    PubMed  CAS  Google Scholar 

  • Assem, E.S.K., Atkinson, G.: Histamine release by MCDP (401), a peptide from the venom of the honey bee. Brit. J. Pharmacol. 48, 337 P–338 P (1973)

    CAS  Google Scholar 

  • Assem, E.S.K., Evans, J.A., McAllen, M.: Inhibition of experimental asthma in man by a new drug (AH 7725) active when given by mouth. Brit. med. J. 2, 93–94 (1974)

    PubMed  CAS  Google Scholar 

  • Assem, E.S.K., Mongar, J.L.: Inhibition of allergic reactions in man and other species by cromoglycate. Int. Arch. Allergy. 38, 68–77 (1970)

    PubMed  CAS  Google Scholar 

  • Assem, E.S.K., Richter, A.W.: Comparison of in vivo and in vitro inhibition of the anaphylactic mechanism by β-adrenergic stimulants and disodium cromoglycate. Immunology 21, 729–739(1971)

    PubMed  CAS  Google Scholar 

  • Assem, E.S.K., Schild, H.O.: Detection of allergy to penicillin and other antigens by in vitro passive sensitization and histamine release from human and monkey lung. Brit. med. J. 1968III, 272–276

    Google Scholar 

  • Assem, E.S.K., Schild, H.O.: Inhibition by sympathomimetic amines of histamine release by antigen in passively sensitised human lung. Nature (Lond.) 224, 1028–1029 (1969)

    PubMed  CAS  Google Scholar 

  • Austen, K.F., Brocklehurst, W.E.: Inhibition of the anaphylactic release of histamine from chopped guinea-pig lung by chymotrypsin substrates and inhibitors. Nature (Lond.) 186, 866–868 (1960)

    PubMed  CAS  Google Scholar 

  • Austen, K.F., Brocklehurst, W.E.: Anaphylaxis in chopped guinea-pig lung. I. Effect of peptidase substrates and inhibitors. J. exp. Med. 113, 521–539 (1961)

    PubMed  CAS  Google Scholar 

  • Barker, G., Ellis, G.P., Shaw, D.: Benzopyrones. 9. Synthesis and pharmacology of some novel bischromones. J. med. Chem. 16, 87–89 (1973)

    PubMed  CAS  Google Scholar 

  • Barlow, R.B.: Introduction to Chemical Pharmacology, 2nd Ed., p. 270. London: Methuen 1964

    Google Scholar 

  • Batchelor, J.F., Follenfant, M.J., Garland, L.G., Gorvin, J.H., Green, A.F., Hodson, H.F., Hughes, D.T.D., Tateson, J.E.: Doxantrazole, an antiallergic agent orally effective in man. Lancet 1975I, 1169–1170

    Google Scholar 

  • Baxter, J.H.: Histamine release from rat mast cells by dextran: Effects of adrenergic agents, theophylline and other drugs. Proc. Soc. exp. Biol. (N.Y.) 141, 576–581 (1972)

    PubMed  CAS  Google Scholar 

  • Baxter, J.H.: Role of Ca++ in mast cell activation, desensitization, and histamine release by dextran. J. Immunol. 111, 1470–1473 (1973)

    PubMed  CAS  Google Scholar 

  • Baxter, J.H., Adamik, R.: Temperature dependence of histamine release from rat mast cells by dextran. Proc. Soc. exp. Biol. (N.Y.) 146, 1–74 (1974)

    Google Scholar 

  • Baxter, J.H., Adamik, R.: Control of histamine release: effects of various conditions on rate of release and rate of cell desensitization. J. Immunol. 114, 1034–1041 (1975)

    PubMed  CAS  Google Scholar 

  • Benner, M., Lowell, F.C.: Failure of diethylcarbamazine citrate (Hetrazan) in the treatment of asthma. J. Allergy 46, 29–31 (1970)

    PubMed  CAS  Google Scholar 

  • Benson, M.K., Curry, S.H., D’A Mills, G.G., Hughes, D.T.D.: Uptake of disodium cromoglycate in obstructive airways disease. Clin. Allergy 3, 389–394 (1973)

    PubMed  CAS  Google Scholar 

  • Berg, T., Johansson, S.G.O.: In vitro diagnosis of atopic allergy. Int. Arch. Allergy 41, 452–462 (1971)

    PubMed  CAS  Google Scholar 

  • Berger, F.M., Fukui, G., Ludwig, B.J., Margolin, S.: Selective suppression of penicillin hypersensitivity by certain phenoxy propanediols. Proc. Soc. exp. Biol. (N.Y.) 124, 303–310 (1967)

    PubMed  CAS  Google Scholar 

  • Binaghi, R.A., Benacerraf, B., Bloch, K.J., Kourilsky, F.M.: Properties of rat anaphylactic antibody. J. Immunol. 92, 927–933 (1964)

    PubMed  CAS  Google Scholar 

  • Bloch, K.J., Morse, H.C., Austen, K.F.: Biologic properties of rat antibodies. I. Antigen-binding by four classes of anti-DNP antibodies. J. Immunol. 101, 650–657 (1968)

    PubMed  CAS  Google Scholar 

  • Bloch, K.J., Wilson, R.J.M.: Homocytotropic antibody response in the rat infected with the nematode, Nippostrongylus brasiliensis. III. Characteristics of the antibody. J. Immunol. 100, 629–636(1968)

    PubMed  CAS  Google Scholar 

  • Blum, J., Ovary, Z.: Evaluation of methods of measurements of permeability increases. Int. Arch. Allergy 46, 121–127(1974)

    PubMed  CAS  Google Scholar 

  • Bonaccorsi, A., West, G.B.: Absence of capillary permeability response in rats to dextran and egg-white. J. Pharm. (Lond.) 15, 372–378 (1963)

    CAS  Google Scholar 

  • Boura, A.L.A., Mongar, J.L., Schild, H.O.: Improved automatic apparatus for pharmacological assays on isolated preparations. Brit. J. Pharmacol. 9, 24–30 (1954)

    PubMed  CAS  Google Scholar 

  • Bourne, H.R., Lichtenstein, L.M., Melmon, K.L.: Pharmacologic control of allergic histamine release in vitro: evidence for an inhibitory role of 3′,5′-adenosine monophosphate in human leukocytes. J. Immunol. 108, 695–705 (1972)

    PubMed  CAS  Google Scholar 

  • Breithaupt, H., Habermann, E.: Mastzelldegranulierendes Peptid (MCD-Peptid) aus Bienengift: Isolierung, biochemische und pharmakologische Eigenschaften. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 261, 252–270 (1968)

    CAS  Google Scholar 

  • Brocklehurst, W.E., Humphrey, J.H., Perry, W.L.M.: The role of histamine in cutaneous antigen-antibody reactions in the rat. J. Physiol. (Lond.) 129, 205–224 (1955)

    PubMed  CAS  Google Scholar 

  • Brocklehurst, W.E., Humphrey, J.H., Perry, W.L.M.: Cutaneous antigen-antibody reactions in the rat. J. Physiol. (Lond.) 150, 489–500 (1960)

    PubMed  CAS  Google Scholar 

  • Broder, L., Taichman, N.S.: Mechanism of histamine release from perfused guinea-pig lung by soluble immune complexes. Immunology 21, 193–205 (1971)

    PubMed  CAS  Google Scholar 

  • Brogden, R.M., Speight, T.M., Avery, G.S.: Sodium cromoglycate (Cromolyn Sodium): a review of its mode of action, pharmacology, therapeutic efficacy and use. Drugs 7, 164–282 (1974)

    PubMed  CAS  Google Scholar 

  • Broughton, B.J., Chaplen, P., Knowles, P., Lunt, E., Pain, D.L., Wooldridge, K.R.H., Ford, R., Marshall, S., Walker, J.L., Maxwell, D.R.: New inhibitor of reagin-mediated anaphylaxis. Nature (Lond.) 251, 650–652 (1974)

    PubMed  CAS  Google Scholar 

  • Broughton, B.J., Chaplen, P., Knowles, P., Lunt, E., Marshall, S.M., Pain, D.L., Wooldridge, K.R.H.: Antiallergic activity of 2-phenyl-8-azapurin-6-ones. J. med. Chem. 18, 1117–1122(1975)

    PubMed  CAS  Google Scholar 

  • Bryant, D.H., Burns, M.W., Lazarus, L.: New type of allergic asthma due to IgG “reaginic” antibody. Brit. med. J. 1973IV, 589–592

    Google Scholar 

  • Bryant, D.H., Burns, M.W., Lazarus, L.: Identification of IgG antibody as a carrier of reaginic activity in asthmatic patients. J. Allergy clin. Immunol. 56, 417–428 (1975)

    PubMed  CAS  Google Scholar 

  • Buckle, D.R., Cantello, B.C.C., Morgan, N.J., Smith, H., Spicer, B.A.: Antiallergic activity of ω-nitroacetophenones. J. med. Chem. 18, 733–736 (1975 b)

    PubMed  CAS  Google Scholar 

  • Buckle, D.R., Cantello, B.C.C., Smith, H., Spicer, B.A.: Antiallergic activity of 4-hydroxy-3-nitro-coumarins. J. med. Chem. 18, 391–394 (1975 c)

    PubMed  CAS  Google Scholar 

  • Buckle, D.R., Cantello, B.C.G, Smith, H., Spicer, B.A.: 4-Hydroxy-3-nitro-2-quinolones and related compounds as inhibitors of allergic reactions. J. med. Chem. 18, 726–732 (1975d)

    PubMed  CAS  Google Scholar 

  • Buckle, D.R., Morgan, N.J., Ross, J.W., Smith, H., Spicer, B.A.: Antiallergic activity of 2-nitroin-dan-1,3-diones. J. med. Chem. 16, 1334–1339 (1973)

    PubMed  CAS  Google Scholar 

  • Buckle, D.R., Morgan, N.J., Smith, H.: Hydroaromatic analogues of 2-nitro-1,3-indandiones. J. med. Chem. 18, 203–206 (1975 a)

    PubMed  CAS  Google Scholar 

  • Burden, D.T., Parkes, M.W., Gardiner, D.G.: Effect of /?-adrenoceptive blocking agents on the response to bronchoconstrictor drugs in the guinea-pig air over-flow preparation. Appendix describing a new modification of the air overflow method. Brit. J. Pharmacol. 41, 122–131 (1971)

    CAS  Google Scholar 

  • Burka, J.F., Eyre, P.: A study of prostaglandins and prostaglandin antagonists in relation to anaphylaxis in calves. Canad. J. Physiol. Pharmacol. 52, 942–951 (1974)

    CAS  Google Scholar 

  • Burka, J.F., Eyre, P.: Modulation of the formation and release of bovine SRS-A in vitro by several anti-anaphylactic drugs. Int. Arch. Allergy 49, 774–781 (1975)

    PubMed  CAS  Google Scholar 

  • Cairns, H., Fitzmaurice, C., Hunter, D., Johnson, P.B., King, J., Lee, T.B., Lord, G.H., Minshull, R., Cox, J.S.G.: Synthesis and structure-activity relationships of disodium cromoglycate and some related compounds. J. med. Chem. 15, 583–589 (1972)

    PubMed  CAS  Google Scholar 

  • Chakrin, L.W., Mengel, J., Young, D., Zaher, C., Krell, R.D., Wardell, J.R.: Enhancement of immediate-type hypersensitivity reactions by N-methyl-N′ {2[(4-methyl-5-imidazolyl)me-thylthio]ethyl} thio urea (SK & F 92058), a histamine H2-receptor antagonist. Fed. Proc. 33, 585 (1974)

    Google Scholar 

  • Chasin, M., Harris, D.N., Phillips, M.B., Hess, S.M.: 1-Ethyl-4-(isopropylidenehydrazino)-1 H-pyrazolo(3,4-b)-pyridine-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009): a potent new inhibitor of cyclic 3′,5′-nucleotide phosphodiesterases. Biochem. Pharmacol. 21, 2443–2450(1972)

    PubMed  CAS  Google Scholar 

  • Church, M.K., Collier, H.O.J., James, G.W.L.: The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat. Brit. J. Pharmacol. 46, 56–65 (1972)

    CAS  Google Scholar 

  • Coulson, C.J., Ford, R.E, Lunt, E., Marshall, S., Pain, D.L., Rogers, LH., Wooldridge, K.R.H.: Antiallergic activity of a series of 8-azaxanthines. Eur op. J. med. Chem. Chim. Ther. 9, 313–317(1974)

    CAS  Google Scholar 

  • Cox, J.S.G.: Disodium cromoglycate (FPL 670) (“Intal”): a specific inhibitor of reaginic antibody—antigen mechanisms. Nature (Lond.) 216, 1328–1329 (1967)

    PubMed  CAS  Google Scholar 

  • Cox, J.S.G.: Disodium cromoglycate. Mode of action and its possible relevance to the clinical use of the drug. Brit. J. Dis. Chest 65, 189–204 (1971)

    PubMed  CAS  Google Scholar 

  • Cox, J.S.G., Altounyan, R.E.C.: Nature and modes of action of disodium cromoglycate (Lomudal). Respiration 27 (Suppl), 292–309 (1970)

    PubMed  Google Scholar 

  • Cox, J.S.G., Beach, J.E., Blair, A.M.J.N., Clarke, A.J., King, J., Lee, T.B., Loveday, D.E.E., Moss, G.F., Orr, T.S.C., Ritchie, J.T., Sheard, P.: Disodium cromoglycate (Intal). In: Ad-vances in Drug Research, Vol. V, pp. 115–196. London-New York: Academic Press 1970

    Google Scholar 

  • Crunkhorn, P., Willis, A.L.: Cutaneous reactions to intradermal prostaglandins. Brit. J. Pharmacol. 41, 49–56 (1971)

    CAS  Google Scholar 

  • Curry, S.H., Taylor, A.J., Evans, S., Godfrey, S., Zeidifard, E.: Disposition of disodium cromoglycate administered in three particle sizes. J. Pharm. (Lond.) 26 Suppl., 79 P (1974)

    Google Scholar 

  • Danaraj, T.J.: The treatment of eosinophilic lung (tropical eosinophilia) with diethylcarbamazine. Quart. J. Med. 27, 243–263 (1958)

    PubMed  CAS  Google Scholar 

  • Davies, G.E.: Antibronchoconstrictor activity of two new phosphodiesterase inhibitors, a triazolopyrazine (ICI 58 301) and a triazolopyrimidine (ICI 63197). J. Pharm. (Lond.) 25, 681–689 (1973)

    CAS  Google Scholar 

  • Davies, G.E., Evans, D.P.: Studies with two new phosphodiesterase inhibitors (ICI 58301 and ICI 63197) on anaphylaxis in guinea-pigs, mice, and rats. Int. Arch. Allergy 45, 467–478 (1973)

    CAS  Google Scholar 

  • Dawson, W., Tomlinson, R.: Effect of cromoglycate and eicosatetraynoic acid on the release of prostaglandins and SRS-A from immunologically challenged guinea-pig lungs. Brit. J. Pharmacol. 52, 107 P–108 P (1974)

    CAS  Google Scholar 

  • Despopoulos, A.: Antihemolytic actions of tricyclic tranquilizers. Structural correlations. Biochem. Pharmacol. 19, 2907–2914 (1970)

    PubMed  CAS  Google Scholar 

  • Drain, D.J., Davy, B., Horlington, M., Howes, J.G.B., Scruton, J.M., Selway, R.A.: The effects of substituting tetrazole for carboxyl in two series of anti-inflammatory phenoxyacetic acids. J. Pharm. (Lond.) 23, 857–864 (1971)

    CAS  Google Scholar 

  • Easty, D.L., Rice, N.S.C., Jones, B.R.: Clinical trial of topical disodium cromoglycate in vernal kerato-conjunctivitis. Clin. Allergy 2, 99–107 (1972)

    PubMed  CAS  Google Scholar 

  • Ellis, G.P., Shaw, D.: Benzopyrones. 7. Synthesis and antiallergic activity of some 2-(5-Tetrazolyl) chromones. J. med. Chem. 15, 865–867 (1972)

    PubMed  CAS  Google Scholar 

  • Evans, D.P., Gilman, D.J., Thomson, D.S., Waring, W.S.: Inhibition of allergic reactions by a novel phenanthroline ICI 74917. Nature (Lond.) 250, 592–593 (1974)

    PubMed  CAS  Google Scholar 

  • Evans, D.P., Lewis, J.A., Thomson, D.S.: An automated fluorimetric assay for the rapid determi-nation of histamine in biological fluids. Life Sci. 12, 327–336 (1973)

    CAS  Google Scholar 

  • Evans, D.P., Marshall, P.W., Thomson, D.S.: Inhibition of immediate hypersensitivity reactions in the rat by ICI 74917 and disodium cromoglycate. Int. Arch. Allergy 49, 417–427 (1975)

    PubMed  CAS  Google Scholar 

  • Evans, D.P., Thomson, D.S.: Histamine release from rat mast cells passively sensitised with homocytotropic (IgE) antibody. Int. Arch. Allergy 43, 217–231 (1972)

    PubMed  CAS  Google Scholar 

  • Evans, D.P., Thomson, D.S.: Inhibition of immediate hypersensitivity reactions in laboratoryanimals by a phenanthroline salt (ICI 74917). Brit. J. Pharmacol. 53, 409–418 (1975)

    CAS  Google Scholar 

  • Eyre, P., Lewis, A.J., Wells, P.W.: Acute systemic anaphylaxis in the calf. Brit. J. Pharmacol. 47, 504–516(1973)

    CAS  Google Scholar 

  • Farmer, J.B., Richards, I.M., Sheard, P., Woods, A.M.: Passive lung anaphylaxis in the rat. Inhibition by disodium cromoglycate (Die Hemmung der passiven Lungen-Anaphylaxis in der Ratte durch di-Natrium Cromoglycate). Naunyn-Schmiedebergs Arch. Pharmacol. 279 Suppl., R 35 (1973)

    Google Scholar 

  • Farmer, J.B., Richards, I.M., Sheard, P., Woods, A.M.: Mediators of passive lung anaphylaxis in the rat. Brit. J. Pharmacol. 55, 57–64 (1975)

    CAS  Google Scholar 

  • Ferraresi, R.W., Roszkowski, A.R, Kepel, E.: Sodium 7-methylsulfinylxanthone-2-carboxylate(SMX), a potent inhibitor of rat reaginic-mediated inflammation. Fed. Proc. 33, 762 (1974)

    Google Scholar 

  • Follenfant, M.J., Garland, L.G., Green, A.F., Tateson, J.E.: 3-(5-tetrazolyl) thioxanthone 10,10-dioxide (TTD) a new orally effective antiallergic. In: Proceedings Sixth International Congress of Pharmacology, Helsinki: p. 360. Sanomaprint (1975 a)

    Google Scholar 

  • Follenfant, M.J., Garland, L.G., Green, A.F., Tateson, J.E.: Some properties of the antiallergic agent 3-(5-tetrazolyl) thioxanthone 10,10-dioxide (TTD) related to its possible mechanism of action. In: Proceedings Sixth International Congress of Pharmacology, Helsinki: p. 360. Sanomaprint (1975 b)

    Google Scholar 

  • Foreman, J.C., Garland, L.G.: Desensitization in the process of histamine secretion induced by antigen and dextran. J. Physiol. (Lond.) 239, 381–391 (1974)

    PubMed  CAS  Google Scholar 

  • Foreman, J.C., Garland, L.G., Mongar, J.L.: The role of calcium in secretory processes: model studies in mast cells. In: Duncan, C.J. (Ed.): Calcium in Biological Systems, Society of Experimental Biology Symposium, pp. 193–218. Cambridge: Cambridge University Press 1976

    Google Scholar 

  • Foreman, J.C., Hallett, M.B., Mongar, J.L.: 45-Calcium uptake in rat peritoneal mast cells. Brit. J. Pharmacol. 55, 283 P–284 P (1975)

    CAS  Google Scholar 

  • Foreman, J.C., Mongar, J.L.: The role of the alkaline earth ions in anaphylactic histamine secretion. J. Physiol. (Lond.) 224, 753–769 (1972)

    PubMed  CAS  Google Scholar 

  • Foreman, J.C., Mongar, J.L., Gomperts, B. D.: Calcium ionophores and movement of calcium ions following the physiological stimulus to a secretory process. Nature (Lond.) 245, 249–251 (1973)

    PubMed  CAS  Google Scholar 

  • Fredholm, B.: Studies on a mast cell degranulating factor in bee venom. Biochem. Pharmacol. 15, 2037–2043 (1966)

    PubMed  CAS  Google Scholar 

  • Fullarton, J., Martin, L.E., Vardey, C.: Studies on the inhibition of cellular anaphylaxis. Int. Arch. Allergy 45, 84–86 (1973 a)

    PubMed  CAS  Google Scholar 

  • Fullarton, J., Vardey, C.J., Atkinson, J.: Comparison of the release of histamine from rat mast cells and human basophil leucocytes. Paper read to the British Society for Immunology, Autumn Meeting (1973 b)

    Google Scholar 

  • Gardiner, T.H., Schanker, L.S.: Absorption of disodium cromoglycate (DSCG) from the rat lung: evidence of carrier transport. Fed. Proc. 33, 513 (1974)

    Google Scholar 

  • Garland, L.G.: Effect of cromoglycate on anaphylactic histamine release from rat peritoneal mast cells. Brit. J. Pharmacol. 49,128–130 (1973)

    CAS  Google Scholar 

  • Garland, L.G.: The action of drugs that suppress histamine release from mast cells. University of London: Ph.D. Thesis 1975

    Google Scholar 

  • Garland, L.G., Mongar, J.L.: Inhibition by cromoglycate of histamine release from rat peritoneal mast cells induced by mixtures of dextran, phosphatidyl serine and calcium ions. Brit. J. Pharmacol. 50, 137–143 (1974)

    CAS  Google Scholar 

  • Garland, L.G., Mongar, J.L.: Differentiation by inhibitors between histamine release induced by dextran and by the ionophore A 23187. Proceedings Sixth International Congress of Pharmacology, p. 361. Helsinki: Samonaprint 1975

    Google Scholar 

  • Garland, L.G., Mongar, J.L.: Differential histamine release by dextran and the ionophore A 23187: the actions of inhibitors. Int. Arch. Allergy 50, 27–42 (1976)

    PubMed  CAS  Google Scholar 

  • Goose, J., Blair, A.M.J.N.: Passive cutaneous anaphylaxis in the rat, induced with two homologous reagin-like antibodies and its specific inhibition with disodium cromoglycate. Immunology 16, 749–760 (1969)

    PubMed  CAS  Google Scholar 

  • Goth, A., Adams, H.R., Knoohuizen, M.: Phosphatidylserine: selective enhancer of histamine release. Science 173, 1034–1035 (1971)

    PubMed  CAS  Google Scholar 

  • Greaves, M.W.: The effect of disodium cromoglycate and other inhibitors on in vitro anaphylactic histamine release from guinea-pig basophil leucocytes. Int. Arch. Allergy 36, 497–505 (1969)

    PubMed  CAS  Google Scholar 

  • Greaves, M.W., Fairley, V.M., Yamamoto, S.: Release of histamine from skin during in vitro anaphylaxis. Int. Arch. Allergy 41, 932–939 (1971)

    PubMed  CAS  Google Scholar 

  • Greaves, M.W., Yamamoto, S., Fairley, V.M.: IgE-mediated hypersensitivity in human skin studied using a new in vitro method. Immunology 23, 239–248 (1972)

    PubMed  CAS  Google Scholar 

  • Haddad, Z.H., Gillman, S.A.: Disodium cromoglycate and human reagin (IgE) mediated reactions. Int. Arch. Allergy 45 439–446 (1973)

    PubMed  CAS  Google Scholar 

  • Hall, C.M., Johnson, H.G., Wright, J.B.: Quinoline derivatives as antiallergy agents. J. med. Chem. 17, 685–690(1974)

    PubMed  CAS  Google Scholar 

  • Hanahoe, T.H.R, Holliman, A., Gordon, D., Wieczorek, W.: Disodium cromoglycate and the dextran response in rats. J. Pharm. (Lond.) 24, 666–667 (1972)

    CAS  Google Scholar 

  • Herbst, R.M.: Tetrazoles as carboxylic acid analogs. In: Graff, S. (Ed.): Essays in Biochemistry, pp. 141–155. New York: John Wiley and Sons Inc. 1956

    Google Scholar 

  • Herzig, D.J., Giles, R.E., Schumann, P.R., Kusner, E.J., Dubnick, B.: 3-(Hydroxymethyl)-8-me-thoxychromone: a new, orally active specific prophylactic inhibitor of reaginic anaphylaxis. Fed. Proc. 34, 760 (1975)

    Google Scholar 

  • Herzig, D.J., Schumann, P.R., Kusner, E.J., Robichaud, L., Giles, R.E., Dubnick, B., von Strandtmann, M, Klutchko, S., Cohen, M. P., Shavel, J. Jr.: The search for specific inhibitors of immediate hypersensitivity reactions. The activity of some chromones in various laboratory models. In: Immunopharmacology, pp. 103–124. New York: Spectrum Press 1975. In press

    Google Scholar 

  • Hines, M.C., Moss, G.F., Cox, J.S.G.: Effect of disodium cromoglycate on phospholipase A activity. Studies with egg yolk and isolated mast cell systems. Biochem. Pharmacol. 21, 171–179(1972)

    PubMed  CAS  Google Scholar 

  • Högberg, B., Uvnäs, B.: The mechanism of the disruption of mast cells produced by Compound 48/80. Acta physiol. scand. 41, 345–369 (1957)

    PubMed  Google Scholar 

  • Holland, A., Jackson, D., Chaplen, P., Lunt, E., Marshall, S.M., Pain, D.L., Wooldridge, K.: Antiallergic activity of 8-azapurin-6-ones with heterocyclic 2-substituents. Europ. J. Med. Chem-Chim. Ther. 10, 447–449 (1975)

    CAS  Google Scholar 

  • Ishizaka, K., Ishizaka, T.: Role of IgE and IgG antibodies in reaginic hypersensitivity in the respiratory tract. In: Austen, K.F., Lichtenstein, L.M. (Eds.): Asthma: Physiology, Immuno-pharmacology, and Treatment, pp. 55–68. New York: Academic Press 1973

    Google Scholar 

  • Ishizaka, T., Ishizaka, K., Lichtenstein, L. M.: Antibody-induced histamine release and degranula- tion of human basophil leukocytes. Fed. Proc. 30,654 (1971 a)

    Google Scholar 

  • Ishizaka, T., Ishizaka, K., Orange, R.P., Austen, K.F.: Pharmacologic inhibition of the antigen-induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from monkey lung tissues mediated by human IgE. J. Immunol. 106, 1267–1273 (1971 b)

    PubMed  CAS  Google Scholar 

  • Jasani, B., Stanworth, D.R.: Studies on the mast cell triggering action of certain artificial histamine liberators. Int. Arch. Allergy 45, 74–81 (1973)

    PubMed  CAS  Google Scholar 

  • Johnson, A.R., Moran, N.C.: Release of histamine from rat mast cells: a comparison of the effects of 48/80 and two antigen-antibody systems. Fed. Proc. 28, 1716–1720 (1969)

    PubMed  CAS  Google Scholar 

  • Johnson, H.G., Bach, M.K.: Prevention of calcium ionophore-induced release of histamine in rat mast cells by disodium cromoglycate. J. Immunol. 114, 514–516 (1975)

    PubMed  CAS  Google Scholar 

  • Johnson, H.G., Vanhout, C.A.: The enhanced efficacy of disodium cromoglycate (DSCG) in DSCG predosed rats. Proc. Soc. exp. Biol. (N.Y.) 143, 427–432 (1973)

    PubMed  CAS  Google Scholar 

  • Johnson, H.G., Vanhout, C.A.: Studies on the mode of action of disodium cromoglycate (DSCG). Enhanced efficacy in predosed rats. Allergol. Immunopath. (Madr.) 2, 33–40 (1974)

    Google Scholar 

  • Jones, V.E., Ogilvie, B.M.: Reaginic antibodies and immunity to Nippostrongylus brasiliensis in the rat. II. Some properties of the antibodies and antigens. Immunology 12, 583–597 (1967)

    PubMed  CAS  Google Scholar 

  • Juby, P.F., Hudyma, T.W., Brown, M.: Preparation and antiinflammatory properties of some 5-(2-anilinophenyl) tetrazoles. J. med. Chem. 11, 111–117 (1968)

    PubMed  CAS  Google Scholar 

  • Kaliner, M., Austen, K.F.: A sequence of biochemical events in the antigen-induced release of chemical mediators from sensitised human lung tissue. J. exp. Med. 138, 1077–1094 (1973)

    PubMed  CAS  Google Scholar 

  • Kaliner, M., Austen, K.F.: Cyclic nucleotides and modulations of effector systems of inflammation. Biochem. Pharmacol. 23, 763–771 (1974a)

    CAS  Google Scholar 

  • Kaliner, M., Austen, K.F.: Hormonal control of the immunologic release of histamine and slowreacting substance of anaphylaxis from human lung. In: Braun, W., Lichtenstein, L.M., Parker, C.W. (Eds.): Cyclic AMP, Cell Growth and the Immune Response, pp. 163–175. Berlin-Heidelberg-New York: Springer 1974 b

    Google Scholar 

  • Kimura, I., Tanizaki, Y., Sato, S., Takahashi, K., Saito, K., Ueda, N.: Morphological changes of basophils in immunological reactions-effect of sodium cromoglycate. Clin. Allergy 5, 181–187(1975)

    PubMed  CAS  Google Scholar 

  • Konzett, H., Rossler, R.: Versuchsanordnung zu Untersuchungen an der Bronchialmuskulatur. Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 195, 71–74 (1940)

    Google Scholar 

  • Koopman, W.J., Orange, R.P., Austen, K.F.: Immunochemical and biologic properties of rat IgE. III. Modulation of the IgE-mediated release of slow-reacting substance of anaphylaxis by agents influencing the level of cyclic 3′,5′-adenosine monophosphate. J. Immunol. 105, 1096–1102 (1970 a)

    CAS  Google Scholar 

  • Koopman, W.J., Orange, R.P., Austen, K.F.: Inhibition by antihistamines of the immunologic release of slow reacting substance of anaphylaxis (SRS-A) in the rat. Trans. Ass. Amer. Phycns 83, 225–234 (1970 b)

    CAS  Google Scholar 

  • Kunze, H., Vogt, W.: Significance of phospholipase A for prostaglandin formation. Ann. N.Y. Acad. Sci. 180, 123–125 (1971)

    PubMed  CAS  Google Scholar 

  • Kusner, E.J., Dubnick, B., Herzig, D.J.: The inhibition by disodium cromoglycate in vitro of anaphylactically induced histamine release from rat peritoneal mast cells. J. Pharmacol, exp. Ther. 184, 41–46(1973)

    CAS  Google Scholar 

  • Kusner, E.J., Herzig, D.J.: An automated fluorimetric method for the determination of histamine from mast cell suspension. In: Advances in Automated Analysis, Vol. II, pp. 429–433. Miami: Thurman Associates 1971

    Google Scholar 

  • Levine, B.B., Chang, H., Vaz, N.M.: The production of hapten-specific reaginic antibodies in the guinea-pig. J. Immunol. 106, 29–33 (1971)

    PubMed  CAS  Google Scholar 

  • Lewis, R.A., Wasserman, S.I., Goetzl, E.J., Austen, K.F.: Formation of slowreacting substance of anaphylaxis in human lung tissue and cells before release. J. exp. Med. 140, 1133–1146 (1974)

    PubMed  CAS  Google Scholar 

  • Lichtenstein, L.M.: The immediate allergic response: in vitro separation of antigen activation, decay and histamine release. J. Immunol. 107, 1122–1130 (1971)

    PubMed  CAS  Google Scholar 

  • Lichtenstein, L.M.: The role of the cyclic AMP system in inflammation: An introduction. In: Braun, W., Lichtenstein, L.M., Parker, C.W. (Eds.): Cyclic AMP, Cell Growth and the Immune Response, pp. 147–162. Berlin-Heidelberg-New York: Springer 1974

    Google Scholar 

  • Lichtenstein, L.M., Adkinson, N.F.: Chlorphenesin: a new inhibitor of IgE-mediated histamine release. J. Immunol. 103, 866–868 (1969)

    PubMed  CAS  Google Scholar 

  • Lichtenstein, L.M., Bourne, H.R.: Inhibition of allergic histamine release by histamine and other agents which stimulate adenyl cyclase. In: Austen, K.F., Becker, E.L. (Eds.): Biochemistry of the Acute Allergic Reactions, pp. 161–173. Oxford: Blackwell 1971

    Google Scholar 

  • Lichtenstein, L.M., Debernardo, R.: The immediate allergic response: in vitro action of cyclic AMP-active and other drugs on the two stages of histamine release. J. Immunol. 107, 1131–1136(1971)

    PubMed  CAS  Google Scholar 

  • Lichtenstein, L.M., Gillespie, E.: Inhibition of histamine release by histamine controlled by H2 receptor. Nature (Lond.) 244, 287–288 (1973)

    PubMed  CAS  Google Scholar 

  • Lichtenstein, L.M., Gillespie, E.: The effects of the H1 and H2 antihistamines on “allergic” histamine release and its inhibition by histamine. J. Pharmacol, exp. Ther. 192, 441–450 (1975)

    CAS  Google Scholar 

  • Lichtenstein, L.M., Margolis, S.: Histamine release in vitro: Inhibition by catecholamines and methylxanthines. Science 161, 902–903 (1968)

    PubMed  CAS  Google Scholar 

  • Lichtenstein, L.M., Osler, A.G.: Studies on the mechanisms of hypersensitivity phenomena. IX. Histamine release from human leukocytes by ragweed pollen antigen. J. exp. Med. 120, 507–530(1964)

    PubMed  CAS  Google Scholar 

  • Lopez, M., Bloch, K.J.: Effect of disodium cromoglycate on certain passive cutaneous anaphylactic reactions. J. Immunol. 103, 1428–1430 (1969)

    PubMed  CAS  Google Scholar 

  • McManus, J.M., Herbst, R.M.: Tetrazole analogues of amino acids. J. org. Chem. 24, 1643–1649 (1959)

    CAS  Google Scholar 

  • Maling, H.M., Webster, M.E., Williams, M.A., Saul, W., Anderson, W.: Inflammation induced by histamine, serotonin, bradykinin, and compound 48/80 in the rat: antagonists and the mech-anism of action. J. Pharmacol, exp. Ther. 191, 300–310 (1974)

    CAS  Google Scholar 

  • Mallen, M.S.: Treatment of intractable asthma with diethylcarbamazine citrate. Ann. Allergy 23, 534–537(1965)

    Google Scholar 

  • Malley, A., Baecher, L.: Inhibition of histamine and SRS-A from monkey lung tissue by chlorphenesin. J. Immunol. 107, 586–588 (1971)

    PubMed  CAS  Google Scholar 

  • Marshall, P.W., Thomson, D.S., Evans, D.P.: The mechanism of tachyphylaxis to ICI 74917 and disodium cromoglycate. Int. Arch. Allergy 51, 274–283 (1976)

    PubMed  CAS  Google Scholar 

  • Marshall, R.: Protective effect of disodium cromoglycate on rat peritoneal mast cells. Thorax 27, 38–43 (1972)

    PubMed  CAS  Google Scholar 

  • Martin, L.E.: Inhibition of cellular anaphylaxis by beta-stimulants. Postgrad, med. J. 47, suppl., 26–30(1971)

    CAS  Google Scholar 

  • Mielens, Z.E., Ferguson, E.W., Rosenberg, F.J.: Effects of anti-anaphylactic drugs upon passive cutaneous anaphylaxis mediated by graded doses of reaginic or non-reaginic antibodies in rats. Int. Arch. Allergy 47, 633–649 (1974)

    PubMed  CAS  Google Scholar 

  • Mihina, J.S., Herbst, R.M.: The reaction of nitriles with hydrazoic acid: synthesis of monosubsti-tuted tetrazoles. J. org. Chem. 15, 1082–1092 (1950)

    CAS  Google Scholar 

  • Miyamoto, T., Reynolds, L.B., Patterson, R., Cugell, P.W., Kettel, L.J.: Respiratory changes in passively sensitised dogs and monkeys as models of allergic asthma. Amer. Rev. resp. Dis. 97, 76–88(1968)

    PubMed  CAS  Google Scholar 

  • Mongar, J.L., Schild, H.O.: Cellular mechanisms in anaphylaxis. Physiol. Rev. 42, 226–270 (1962)

    PubMed  CAS  Google Scholar 

  • Mongar, J.L., Svec, P.: The effect of phospholipids on anaphylactic histamine release. Brit. J. Pharmacol. 46, 741–752 (1972)

    CAS  Google Scholar 

  • Moran, N.C., Uvnäs, B., Westerholm, B.: Release of 5-hydroxytryptamine and histamine from rat mast cells. Acta physiol. scand. 56, 26–41 (1962)

    CAS  Google Scholar 

  • Morse, H.C., Austen, K.F., Bloch, K.J.: Biological properties of rat antibodies. III. Histamine release mediated by two classes of antibodies. J. Immunol. 102, 327–337 (1969)

    PubMed  CAS  Google Scholar 

  • Moss, G.F., Jones, K.M., Ritchie, J.T., Cox, J.S.G.: Distribution and metabolism of disodium cromoglycate in rats. Toxicol. appl. Pharmacol. 17, 691–698 (1970)

    PubMed  CAS  Google Scholar 

  • Moss, G.F., Jones, K.M., Ritchie, J.T., Cox, J.S.G.: Plasma levels and urinary excretion of diso-dium cromoglycate after inhalation by human volunteers. Toxicol. appl. Pharmacol. 20, 147–156(1971)

    PubMed  CAS  Google Scholar 

  • Moss, G. F., Ritchie, J. T.: The absorption and clearance of disodium cromoglycate from the lung in rat, rabbit, and monkey. Toxicol. appl. Pharmacol. 17, 699–707 (1970)

    PubMed  CAS  Google Scholar 

  • Mota, I.: The mechanism of anaphylaxis. I. Production and biological properties of “mast cell sensitizing” antibody. Immunology 7, 681–699 (1964)

    PubMed  CAS  Google Scholar 

  • Mota, I.: Biological characterisation of mouse “early” antibodies. Immunology 12, 343–348 (1967)

    PubMed  CAS  Google Scholar 

  • Mota, I., Dias da Silva, W.: The anti-anaphylactic and histamine-releasing properties of the antihistamines. Their effect on the mast cells. Brit. J. Pharmacol. 15, 396–404 (1960)

    PubMed  CAS  Google Scholar 

  • Neale, M.G., Moss, G.F.: Effect of inducers on the metabolism and excretion of disodium cromo-glycate in rats. Biochem. J. 130, 85 P–86 P (1972)

    CAS  Google Scholar 

  • Newman, D.J., Spainhour, Jr., C.B., Brann, E.G.: Partial purification and properties of cAMP-phosphodiesterase isolated from guinea pig tracheal muscle. Fed. Proc. 34, 261 Abstr. (1975)

    Google Scholar 

  • Nohara, A., Kuriki, H., Saijo, T., Ukawa, K., Murata, T., Kanno, M., Sanno, Y.: Studies on anti-anaphylactic agents. 4. Synthesis and structure-activity relationships of 3-(4-oxo-4H-l-ben-zopyran-3) acrylic acids, a new series of antiallergic substances, and some related com-pounds. J. med. Chem. 18, 34–37 (1975)

    CAS  Google Scholar 

  • Ogilvie, B.M.: Reagin-like antibodies in animals immune to helminth parasites. Nature (Lond.) 204, 91–92(1964)

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Austen, K.F.: Pharmacologic dissociation of immunologic release of histamine and slow reacting substance of anaphylaxis in rats. Proc. Soc. exp. Biol. (N.Y.) 129, 836–841 (1968)

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Austen, K.F.: Slow reacting substance of anaphylaxis in the rat. In: Cellular and Humoral Mechanisms in Anaphylaxis and Allergy, pp. 196–206. Basel-New York: Karger 1969

    Google Scholar 

  • Orange, R.P., Austen, K.F.: Drug-induced modulation of the immunologic release of histamine and slow reacting substance of anaphylaxis. Int. Arch. Allergy 41, 79–85 (1971)

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Austen, W.G., Austen, K.F.: Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. J. exp. Med. 134, 136–148 (1971)

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Murphy, R.C., Karnovsky, M.L., Austen, K.F.: The physicochemical characteristics and purification of slow reacting substance of anaphylaxis. J. Immunol. 110, 760–770 (1973)

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Stechschulte, D.J., Austen, K.F.: Immunochemical and biological properties of rat IgE. II. Capacity to mediate the immunologic release of histamine and slow reacting substance of anaphylaxis (SRS-A). J. Immunol. 105, 1087–1095 (1970)

    PubMed  CAS  Google Scholar 

  • Orange, R.P., Valentine, M.D., Austen, K.F.: Antigen-induced release of slow reacting substance of anaphylaxis (SRS-A rat) in rats prepared with homologous antibody. J. exp. Med. 127, 767–782(1968)

    PubMed  CAS  Google Scholar 

  • Orr, T.S.C.: The mast cell and disodium cromoglycate in immediate type reactions. Acta tuberc. pneumol. belg. 65, 300–307 (1974)

    PubMed  CAS  Google Scholar 

  • Orr, T.S.C., Blair, A.M.J.N.: Potentiated reagin response to egg albumin and conalbumin in Nippostrongylus brasiliensis infected rats. Life Sci. 8, 1073–1077 (1969)

    PubMed  CAS  Google Scholar 

  • Orr, T.S.C., Cox, J.S.G.: Disodium cromoglycate, an inhibitor of mast cell degranulation and histamine release induced by phospholipase A. Nature (Lond.) 223, 197–198 (1969)

    PubMed  CAS  Google Scholar 

  • Orr, T.S.C., Gwilliam, J., Cox, J.S.G.: Studies on passive cutaneous anaphylaxis in the rat with disodium cromoglycate. I. Cutaneous reactions induced by an anti-DNP 7Sγ2 antibody. Immunology 19, 469–479 (1970b)

    PubMed  CAS  Google Scholar 

  • Orr, T.S.C., Gwilliam, J., Cox, J.S.G.: Studies on passive cutaneous anaphylaxis in the rat with disodium cromoglycate. II. A comparison of the rat anti-DNP 7Sγ2 and rat reagin induced cutaneous reactions. Immunology 21, 405–417 (1971 a)

    PubMed  CAS  Google Scholar 

  • Orr, T.S.C., Hall, D.E., Gwilliam, J.M., Cox, J.S.G.: The effect of disodium cromoglycate on the release of histamine and degranulation of rat mast cells induced by compound 48/80. Life Sci. 10, 805–812 (1971b)

    CAS  Google Scholar 

  • Orr, T.S.C., Pollard, M.C., Gwilliam, J., Cox, J.S.G.: Mode of action of disodium cromoglycate studies on immediate type hypersensitivity reactions using “double sensitization” with two antigenically distinct rat reagins. Clin. exp. Immunol. 7, 745–757 (1970 a)

    PubMed  CAS  Google Scholar 

  • Orr, T.S.C., Riley, P., Doe, J.E.: Potentiated reagin response to egg albumin in Nippostrongylus brasiliensis infected rats. II. Time course of the reagin response. Immunology 20, 185–189 (1971c)

    PubMed  CAS  Google Scholar 

  • Parish, W.E.: Release of histamine and slow reacting substance with mast cell changes after challenge of human lung sensitized passively with reagin in vitro. Nature (Lond.) 215, 738–739 (1967)

    PubMed  CAS  Google Scholar 

  • Parish, W.E.: A human heat-stable anaphylactic or anaphylactoid antibody which may partici-pate in pulmonary disorders. In: Austen, K.F., Lichtenstein, L.M. (Eds.): Asthma: Physiol-ogy, Immunopharmacology, and Treatment, pp. 71–89. New York: Academic Press 1973

    Google Scholar 

  • Parish, W.E.: Some biological activities of IgG subclass antibodies after inoculation and in disease. In: Ganderton, M. A., Frankland, A. W. (Eds.): Allergy 74, Proceedings of the Ninth European Congress of Allergology and Clinical Immunology, pp. 153–175. New York: Pitman Medical Publ. 1975

    Google Scholar 

  • Parratt, J.R., West, G.B.: 5-Hydroxytryptamine and tissue mast cells. J. Physiol. (Lond.) 137, 169–178 (1957 a)

    PubMed  CAS  Google Scholar 

  • Parratt, J.R., West, G.B.: Release of 5-hydroxytryptamine and histamine from tissues of the rat. J. Physiol. (Lond.) 137, 179–192 (1957 b)

    PubMed  CAS  Google Scholar 

  • Parratt, J.R., West, G.B.: 5-Hydroxytryptamine and the anaphylactoid reaction in the rat. J. Physiol. (Lond.) 139, 27–41 (1957 c)

    PubMed  CAS  Google Scholar 

  • Patterson, R., Talbot, C.H.: Respiratory responses in sub-human primates with immediate-type hypersensitivity. J. Lab. clin. Med. 73, 924–933 (1969)

    PubMed  CAS  Google Scholar 

  • Patterson, R., Talbot, C.H., Brandfonbrener, M.: The use of IgE mediated responses as a pharma-cologic test system. The effect of disodium cromoglycate in respiratory and cutaneous reactions and on the electrocardiograms of rhesus monkeys. Int. Arch. Allergy 41, 592–603 (1971)

    PubMed  CAS  Google Scholar 

  • Pearce, C.A., Greaves, M.W., Plummer, V.M., Yamamoto, S.: Effect of disodium cromoglycate on antigen-evoked histamine release from human skin. Clin. exp. Immunol. 17, 437–440 (1974)

    PubMed  CAS  Google Scholar 

  • Pepys, J.: Disodium cromoglycate in clinical and experimental asthma. In: Austen, K.F., Lichtenstein, L.M. (Eds.): Asthma: Physiology, Immunopharmacology, and Treatment, pp. 279–292. New York: Academic Press 1973

    Google Scholar 

  • Piper, P.J., Walker, J.L.: The release of spasmogenic substances from human chopped lung tissue and its inhibition. Brit. J. Pharmacol. 47, 291–304 (1973)

    CAS  Google Scholar 

  • Pfister, J.R., Ferraresi, R.W., Harrison, I.T., Rooks, W.H., Roszkowski, A.P., Van Horn, A.: Xan-thone-2-carboxylic acids, a new series of antiallergic substances. J. med. Chem. 15, 1032–1035 (1972)

    PubMed  CAS  Google Scholar 

  • Possanza, G.J., Bauen, A., Stewart, P.B.: Effect of a benzopyrano benzopyran (PR-D-92-EA) on the mediators of allergy in vitro. Pharmacologist 16,198 (1974)

    Google Scholar 

  • Possanza, G.J., Bauen, A., Stewart, P.B.: In vitro antagonism of the mediators of allergy by a benzopyrano-benzopyran carboxylic acid PR-D-92-EA. Int. Arch. Allergy 49, 789–795 (1975)

    PubMed  CAS  Google Scholar 

  • Poyser, R.H., West, G.B.: Structural requirements of sugars as antagonists of the vascular response to dextran in rat skin. Brit. J. Pharmacol. 32, 219–226 (1968)

    PubMed  CAS  Google Scholar 

  • Rachelefsky, G.S., Lavin, N., Kaplan, S.A.: An action of cromolyn sodium (CS): Inhibition of cyclic 3′,5′-adenosine monophosphate (cAMP) phosphodiesterase (PDE). J. Allergy 55, 117–118(1975)

    Google Scholar 

  • Riley, P.A., Sheard, P., Clarke, A.J., Orr, T.S.C.: The effect of predosage with disodium cromoglycate (DSCG) on the dose-related inhibition of rat passive cutaneous anaphylaxis by DSCG. Life Sci. 17, 793–802 (1975)

    PubMed  CAS  Google Scholar 

  • Roesch, E., Roesch, A.: The local dextran reaction in skin of rats as influenced by beta-adrenergic mechanisms and the cyclic AMP-system. Naunyn Schmiedeberg’s Arch. Pharmacol. 279, R 15 (1973)

    Google Scholar 

  • Ross, J.W., Smith, H., Spicer, B.A.: Increased vascular permeability during passive peritoneal anaphylaxis (PPA) in the rat. The effects of disodium cromoglycate and a nitroindandione. Int. Arch. Allergy 51, 226–237 (1976)

    PubMed  CAS  Google Scholar 

  • Roszkowski, A.P., Ferraresi, R.W., Schuler, M.E., Sullivan, B.J.: Pharmacological properties of sodium 7-isopropoxy-xanthone 2-carboxylate (IXC). Fed. Proc. 33, 569 (1974)

    Google Scholar 

  • Rothschild, A.M.: Histamine release by bee venom phospholipase A and mellitin in the rat. Brit. J. Pharmacol. 25, 59–66 (1965)

    PubMed  CAS  Google Scholar 

  • Rothschild, A.M.: Mechanisms of histamine release by compound 48/80. Brit. J. Pharmacol. 38, 253–262(1970)

    CAS  Google Scholar 

  • Roy, A.C., Warren, B.T.: Inhibition of cAMP phosphodiesterase by disodium cromoglycate. Biochem. Pharmacol. 23, 917–920 (1974)

    PubMed  CAS  Google Scholar 

  • Schmutzler, W., Derwall, R., Poblete Freundt, G.: The effects of catecholamines and of disodium cromoglycate (DSCG) on the cyclic AMP and the anaphylactic release of histamine in the guinea pig lung. Naunyn Schmiedeberg’s Arch. Pharmacol. 277, R67 (1973)

    Google Scholar 

  • Sheard, P., Blair, A.M.J.N.: Disodium cromoglycate. Activity in three in vitro models of the immediate hypersensitivity reaction in lung. Int. Arch. Allergy 38, 217–224 (1970)

    PubMed  CAS  Google Scholar 

  • Sheard, P., Killingback, P.G., Blair, A.M. J.N.: Antigen induced release of histamine and SRS-A from human lung passively sensitized with reaginic serum. Nature (Lond.) 216, 283–284 (1967)

    PubMed  CAS  Google Scholar 

  • Sheppard, H., Wiggan, G.: Different sensitivities of the phosphodiesterases (adenosine-3′,5′-cyclic phosphate 3′-phosphohydrolase) of dog cerebral cortex and erythrocytes to inhibition by synthetic agents and cold. Biochem. Pharmacol. 20, 2128–2130 (1971)

    PubMed  CAS  Google Scholar 

  • Shore, P.A., Burkhalter, A., Cohn, V.H.: A method for the fluorometric assay of histamine in tissues. J. Pharmacol, exp. Ther. 127, 182–186 (1959)

    CAS  Google Scholar 

  • Siraganian, P.A., Siraganian, R.P.: Basophil activation by concanavalin A: characteristics of the reaction. J. Immunol. 112, 2117–2125 (1974)

    PubMed  CAS  Google Scholar 

  • Spicer, B.A., Ross, J.W., Smith, H.: Inhibition of immediate hypersensitivity reactions in the rat by disodium cromoglycate and a nitroindanedione. Clin. exp. Immunol. 21, 419–429 (1975)

    PubMed  CAS  Google Scholar 

  • Sprenkle, A.C., Van Arsdel, P.P., Bierman, C.W.: New class of antiallergic compounds effective in man. J. Allergy 55, 118 (1975)

    Google Scholar 

  • Stechschulte, D.J., Orange, R.P., Austen, K.F.: Immunochemical and biologic properties of rat IgE. I. Immunochemical identification of rat IgE. J. Immunol. 105, 1082–1086 (1970)

    PubMed  CAS  Google Scholar 

  • Stewart, P.B., Bell, R., Goodfriend, L.: Pharmacological differentiation of monkey lung and skin mast cell-reagin reactions in vitro. In: Goodfriend, L., Sehon, A.H., Orange, R.P. (Eds.): Mechanisms in Allergy. Reagin-Mediated Hypersensitivity, pp. 457–466. New York: Marcel Dekker Inc. 1973

    Google Scholar 

  • Stewart, P.B., Devlin, J.P., Freier, K.R.: Anti-allergic activity of a benzopyrano benzopyran PR-D-92-EA. Fed. Proc. 33, 762 (1974)

    Google Scholar 

  • Stotland, L.M., Share, N.N.: Pharmacological studies on active bronchial anaphylaxis in the rat. Canad. J. Physiol. Pharmacol. 52, 1119–1125 (1974)

    CAS  Google Scholar 

  • Taichman, N.S., Movat, H.Z.: Do polymorphonuclear leukocytes play a role in passive cutaneous anaphylaxis of the guinea-pig? Int. Arch. Allergy 30, 97–102 (1966)

    PubMed  CAS  Google Scholar 

  • Tateson, J.E., Trist, D.G.: Inhibition of adenosine-3′,5′-cyclic monophosphate phosphodiesterase by potential antiallergic compounds. Life Sci. 18, 153–162 (1976)

    PubMed  CAS  Google Scholar 

  • Tattrie, N.H.: Positional distribution of saturated and unsaturated fatty acids on egg lecithin. J. Lipid Res. 1, 60–65 (1959)

    CAS  Google Scholar 

  • Tay, GH., Yeoh, T.S., Greaves, M.W.: Spontaneous and evoked histamine release from guinea pig skin in vitro in presence of disodium cromoglycate. Int. Arch. Allergy 43, 390–394 (1972)

    PubMed  CAS  Google Scholar 

  • Taylor, G., Shivalkar, P.R.: Disodium cromoglycate: laboratory studies and clinical trial in al-lergic rhinitis. Clin. Allergy 1, 189–198 (1971)

    PubMed  CAS  Google Scholar 

  • Taylor, W.A.: The effect of disodium cromoglycate and PGF2α on acute cutaneous reactions of the guinea pig and rat. Int. Arch. Allergy 45, 82–83 (1973)

    PubMed  CAS  Google Scholar 

  • Taylor, W.A.: Control of mast cell degranulation. In: Ganderton, M.A., Frankland, A. W. (Eds.): Allergy 74. Proceedings of the Ninth European Congress of Allergology and Clinical Immunology, pp. 256–266. New York: Pitman Medical Publishers 1975

    Google Scholar 

  • Taylor, W.A., Francis, D.H., Sheldon, D., Roitt, I.M.: The anti-anaphylactic actions of disodium cromoglycate, theophylline, isoprenaline, and prostaglandins. Int. Arch. Allergy 46, 104–120 (1974 a)

    PubMed  CAS  Google Scholar 

  • Taylor, W.A., Francis, D.H., Sheldon, D., Roitt, I.M.: Anti-allergic actions of disodium cromogly-cate and other drugs known to inhibit cyclic 3′,5′-nucleotide phosphodiesterase. Int. Arch. Allergy 47, 175–193 (1974 b)

    PubMed  CAS  Google Scholar 

  • Taylor, W.A., Roitt, I.M.: Effect of disodium cromoglycate on various types of anaphylactic reaction in the guinea pig. Int. Arch. Allergy 45, 795–807 (1973)

    PubMed  CAS  Google Scholar 

  • Taylor, W.A., Sheldon, D.: Mast cell degranulation. A comparison of the inhibitory actions of disodium cromoglycate, drugs known to influence the level of intracellular cyclic nucleotide and diisopropylfluorophosphate (DFP). Int. Arch. Allergy 47, 696–707 (1974)

    PubMed  CAS  Google Scholar 

  • Thomson, D.S., Evans, D.P.: Inhibition of immediate hypersensitivity reactions by disodium cromoglycate. Requirements for activity in two laboratory models. Clin. exp. Immunol. 13, 537–544(1973)

    PubMed  CAS  Google Scholar 

  • Udaka, K., Takeuchi, Y., Movat, H.Z.: Simple method for quantitation of enhanced vascular permeability. Proc. Soc. exp. Biol. (N.Y.) 133, 1384–1387 (1970)

    CAS  Google Scholar 

  • Uvnäs, B., Antonsson, J.: Triggering action of phosphatidase A and chymotrypsins on degranulation of rat mesentery mast cells. Biochem. Pharmacol. 12, 867–873 (1963)

    Google Scholar 

  • Voorhees, A.B., Baker, H.J., Pulaski, E.J.: Reactions of albino rats to injections of dextran. Proc. Soc. exp. Biol. (N.Y.) 76, 254–256 (1951)

    CAS  Google Scholar 

  • Walker, D.M., Dolby, A.E.: Effect of disodium cromoglycate on lymphocyte response to antigen and mitogen. Int. Arch. Allergy 49, 303–309 (1975)

    PubMed  CAS  Google Scholar 

  • Walker, S.R., Evans, M.E., Richards, A.J., Paterson, J.W.: The fate of [14C] disodium cromoglycate in man. J. Pharm. (Lond.) 24, 525–531 (1972)

    CAS  Google Scholar 

  • Watanabe, S., Nakamura, K., Koda, A.: Experimental asthma caused by homocytotropic anti-body in guinea pigs. Proceedings Sixth International Congress of Pharmacology, p. 494. Helsinki: Sanomaprint 1975

    Google Scholar 

  • Wells, P.W., Eyre, P.: The pharmacology of passive cutaneous anaphylaxis in the calf. Canad. J. Physiol. Pharmacol. 50, 255–262 (1972)

    CAS  Google Scholar 

  • Wright, J.B., Johnson, H.G.: Antiasthma agents. I. 4-Oxo-4#-[l]benzothieno[3,2-b]pyran-2-carboxylic acid and 4-oxo-4 H-[l]benzofuro[3,2-b]pyran-2-carboxylic acid. J. med. Chem. 16,861–862(1973)

    PubMed  CAS  Google Scholar 

  • Zeller, E.A., Bissegger, A.: Über die Cholin-esterase des Gehirns und der Erythrocyten. Helv. chim. Acta 26, 1619–1630 (1943)

    CAS  Google Scholar 

  • Zvaifler, N.J., Bauer, H., Robinson, J.O.: IgE immunoglobulin in the rabbit. In: Austen, K.F., Becker, E. L. (Eds.): Biochemistry of the Acute Allergic Reactions, pp. 34–42. Oxford: Black-well 1971

    Google Scholar 

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Authors
  1. L. G. Garland
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  2. A. F. Green
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  3. H. F. Hodson
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Editor information

Editors and Affiliations

  1. The Wellcome Research Laboratories, Langley Court, BR3 3BS, Beckenham, Kent, UK

    John R. Vane

  2. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, CEP 14.100, São Paulo, Brazil

    Sergio H. Ferreira

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© 1979 Springer-Verlag Berlin Heidelberg

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Garland, L.G., Green, A.F., Hodson, H.F. (1979). Inhibitors of the Release of Anaphylactic Mediators. In: Vane, J.R., Ferreira, S.H. (eds) Anti-Inflammatory Drugs. Handbook of Experimental Pharmacology, vol 50 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66891-3_16

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  • DOI: https://doi.org/10.1007/978-3-642-66891-3_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66893-7

  • Online ISBN: 978-3-642-66891-3

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