Skip to main content
SpringerLink
Log in

The Release of Hydrolytic Enzymes From Phagocytic and Other Cells Participating in Acute and Chronic Inflammation

  • Chapter
Book cover Inflammation

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 50 / 1))

Abstract

The release of hydrolytic enzymes by cells present at sites of inflammation is now well recognized. These enzymes are released following either the death of cells after interaction with cytotoxic agents or in a selective manner, where hydrolase release occurs by secretion from viable cells. The latter process has attracted much attention in recent years since it constitutes a mechanism by which hydrolytic enzymes can be released in a directed manner towards an extracellular stimulus. Also viable cells under certain conditions, can be induced to release newly synthesized hydrolases over a long period of time, illustrating a possible mechanism by which tissue damage, degradation and remodelling seen during chronic inflammatory processes can occur.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allison, A.C.: Lysosomes and the response of cells to toxic materials. Sci. Basis Med. 18–30 (1968)

    Google Scholar 

  • Allison, A.C.: Lysosomes and the toxicity of particulate pollutants. Arch, intern. Med. 128, 131–139 (1971)

    CAS  Google Scholar 

  • Allison, A.C., Davies, P.: Mechanisms underlying chronic inflammation. In: Velo, G.P., Willoughby, D.A., Giroud, J.P. (Eds.): Future Trends in Inflammation, pp. 449–480. Padua-London: Piccin Medical Books 1974

    Google Scholar 

  • Allison, A.C., Davies, P.: Increased biochemical and biological activities of mononuclear phagocytes exposed to various stimuli with special reference to lysosomal enzymes. In: Furth, R. (Ed.): Mononuclear Phagocytes in Immunity, Infection and Pathology, pp. 487–506. Oxford: Blackwell 1975

    Google Scholar 

  • Allison, A.C., Davies, P., De Petris, S.: Role of contractile microfilaments in macrophage movement and endocytosis. Nature (New Biol.) 232, 153–155 (1971)

    CAS  Google Scholar 

  • Allison, A.C., Harington, J.C., Birbeck, M.: An examination of the cytotoxic effects of silica on macrophages. J. exp. Med. 124, 141–153 (1966)

    PubMed  CAS  Google Scholar 

  • Aronson, Jr. N.N., De Duve, C.: Digestive activity of lysosomes. II. The digestion of macromolecular carbohydrates by extracts of rat liver lysosomes. J. biol. Chem. 243, 4564–4573 (1968)

    PubMed  CAS  Google Scholar 

  • Axline, S.G., Cohn, Z.A.: In vitro induction of lysosomal enzymes by phagocytosis. J. exp. Med. 131, 1239–1260 (1970)

    PubMed  CAS  Google Scholar 

  • Axline, S.G., Reaven, E.P.: Inhibition of phagocytosis and plasma membrane. Mobility of the cultivated macrophage by cytochalasin B. Role of subplasmalemmal microfilaments. J. Cell Biol. 64, 647–659 (1974)

    Google Scholar 

  • Ayoub, E.M., McCarty, M.: Intraphagocytic ß-N-acetyl glucosaminidase: properties of the enzyme and its activity on Group A streptococcal carbohydrate in comparison with a soil bacillus enzyme. J. exp. Med. 127, 833–851 (1968)

    PubMed  CAS  Google Scholar 

  • Baggiolini, M., Hirsch, J.G., De Duve, C.: Resolution of granules from rabbit heterophil leucocytes into distinct population by zonal sedimentation. J. Cell Biol. 40, 529–549 (1969)

    PubMed  CAS  Google Scholar 

  • Balow, J.E., Rosenthal, A.S.: Glucocorticoid suppression of macrophage migration inhibition factor. J. exp. Med. 137, 1031–1041 (1973)

    PubMed  CAS  Google Scholar 

  • Barbanti-Brodano, G., Fiume, L.: Selective killing of macrophages by amanitin-albumin conjugates. Nature (New Biol.) 243, 281–283 (1973)

    CAS  Google Scholar 

  • Barland, P., Novikoff, A.B., Hameran, D.: Electron microscopy of the human synovial membrane. J. Cell Biol. 14, 207–220 (1962)

    PubMed  CAS  Google Scholar 

  • Barratt, M.E.J.: The role of soft connective tissue in the response of pig articular cartilage in organ culture to excess of retinoL.J. Cell Sci. 13, 205–219 (1972)

    Google Scholar 

  • Barrett, A.J.: Properties of lysosomal enzymes. In: Dingle, J.T., Fell, H.B. (Eds.): Lysosomes in Biology and Pathology, Vol. 2, pp. 245–312. London-Amsterdam: North Holland 1969

    Google Scholar 

  • Becker, E.L., Henson, P.M.: In vitro studies of immunologically induced secretion of mediators from cells and related phenomena. Advanc. Immunol. 17, 93–193 (1973)

    CAS  Google Scholar 

  • Becker, E.L., Showell, H.J., Henson, P.M., Hsu, L.S.: The ability of chemotactic factors to induce lysosomal enzyme release. I. The characteristics of release, the importance of surfaces and the relation of enzyme release to chemotactic responsiveness. J. Immunol. 112, 2047–2054 (1974)

    PubMed  CAS  Google Scholar 

  • Benitz, K.F., Hall, L.M.: Local morphological response following a single subcutaneous injection of carrageenan in the rat. Proc. Soc. exp. Biol. (N.Y.) 102, 442–445 (1959)

    CAS  Google Scholar 

  • Berken, B., Benaceraff, B.: Properties of antibodies cytophilic for macrophages macrophages. J. exp. Med. 123, 119–144 (1966)

    PubMed  CAS  Google Scholar 

  • Bretz, U., Baggiolini, M.: Association of the alkaline phosphatase of rabbit polymorphonuclear leucocytes with the membrane of the specific granules. J. Cell Biol. 59, 696–707 (1973)

    PubMed  CAS  Google Scholar 

  • Bretz, U., Baggiolini, M.: Biochemical and morphological characterization of azurophil and specific granules of human neutrophilic polymorphonuclear leucocytes. J. Cell Biol. 63, 251–269 (1974)

    PubMed  CAS  Google Scholar 

  • Burger, R., Hadding, U., Schorlemmer, H.U., Brade, V., Bitter-Suerman, D.: Dextran sulphate: a synthetic activator of C3 via the alternative pathway. I. Influence of molecular size and degree of sulphation on the activation potency. Immunology 29, 549–554 (1975)

    PubMed  CAS  Google Scholar 

  • Burke, J.S., Urihara, T.S., Macmorine, D.R.L., Movat, H.Z.: A permeability factor released from phagocytosing PMN leucocytes and its inhibition by protease inhibitors. Life Sci. 3, 1505–1512 (1964)

    PubMed  CAS  Google Scholar 

  • Cardella, C.J., Davies, P., Allison, A.C.: Immune complexes induce selective release of lysosomal hydrolases from macrophages in vitro. Nature (Lond.) 247, 46–48 (1974)

    CAS  Google Scholar 

  • Carter, S.D.: Effects of cytochalasins on mammalian cells. Nature (Lond.) 213, 261–264 (1967)

    CAS  Google Scholar 

  • Chang, J., Freer, R., Stella, R., Greenbaum, L.M.: Studies on leucokinins. II. Studies on the formation, partial amino acid sequence and chemical properties of leucokinins M and PMN. Biochem. Pharmacol. 21, 3095–3106 (1972)

    PubMed  CAS  Google Scholar 

  • Cochrane, C.G., Unanue, E.R., Dixon, F.J.: A role of polymorphonuclear leucocytes and complement in nephrotoxic nephritis. J. exp. Med. 122, 99–116 (1965)

    PubMed  CAS  Google Scholar 

  • Coffey, J.W., DeDuve, C.: Digestive activity of lysosomes. I. The digestion of proteins by extracts of rat liver lysosomes. J. biol. Chem. 243, 3255–3263 (1968)

    PubMed  CAS  Google Scholar 

  • Cohn, Z.A., Wiener, E.: The particulate hydrolases of macrophages. II. Biochemical and morphological response to particulate ingestion. J. exp. Med. 118, 1009–1018 (1963)

    PubMed  CAS  Google Scholar 

  • Cooke, T.D., Hurd, E.R., Ziff, M., Jasin, H.E.: The pathogenesis of chronic inflammation in experimental antigen-induced arthritis. II. Preferential localization of antigen-antibody complexes to collagenous tissues. J. exp. Med. 135, 323–338 (1972)

    PubMed  CAS  Google Scholar 

  • Coombs, R.R.A., Fell, H.B.: Lysosomes in tissue damage mediated by allergic reactions. In: Dingle, J.T., Fell, H.B. (Eds.): Lysosomes in Biology and Pathology, pp. 3–18. London-Amsterdam: North Holland 1969

    Google Scholar 

  • Coombs, R.R.A., Gell, P.G.H.: Clinical aspects of immunology, 2nd Ed., pp. 575–596. Oxford: Blackwell 1968

    Google Scholar 

  • Crowder, J.C., Martin, R.R., White, A.: Release of histamine and lysosomal enzymes by human leucocytes during phagocytosis of staphylococci. J. Lab. clin. Med. 74, 436–444 (1969)

    PubMed  CAS  Google Scholar 

  • Davey, M.G., Lüscher, E.F.: Release reactions of human platelets induced by thrombin and other agents. Biochim. biophys. Acta 165, 490–506 (1968)

    CAS  Google Scholar 

  • David, J., David, R.A.: Cell hypersensitivity and immunity. Progr. Allergy 16, 300–449 (1972)

    CAS  Google Scholar 

  • Davies, P., Allison, A.C.: Secretion of macrophage enzymes in relation to pathogenesis of chronic inflammation. In: Nelson, D.S. (Ed.): Immunobiology of the Macrophage, pp. 428–463. London-New York: Academic Press 1976 a

    Google Scholar 

  • Davies, P., Allison, A.C.: The macrophage as a secretory cell in chronic inflammation. Agents Actions 6, 60–74 (1976b)

    PubMed  CAS  Google Scholar 

  • Davies, P., Allison, A.C., Ackerman, J., Butterfield, A., Williams, S.: Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytes. Nature (Lond.) 251, 423–425 (1974b)

    CAS  Google Scholar 

  • Davies, P., Allison, A.C., Dym, M., Cardella, C.J.: The selective release of lysosomal enzymes from mononuclear phagocytes by immune complexes and other materials causing chronic inflammation. In: Dumond, D.C. (Ed.): Infection and Immunology in the Rheumatic Diseases, pp. 365–373. New York: Blackwell 1975

    Google Scholar 

  • Davies, P., Fox, R., Polyzonis, M., Allison, A.C., Haswell, A.D.: The inhibition of phagocytosis and facilitation of exocytosis in rabbit polymorphonuclear leucocytes by cytochalasin B. Lab. Invest. 28, 16–23 (1973)

    PubMed  CAS  Google Scholar 

  • Davies, P., Page, R.C., Allison, A.C.: Changes in cellular enzyme levels and extracellular release of lysosomal acid hydrolases in macrophages exposed to Group A streptococcal cell wall substance. J. exp. Med. 139, 1262–1282 (1974a)

    PubMed  CAS  Google Scholar 

  • Davies, P., Rita, G.A., Krakauer, K., Weissmann, G.: Characterization of a neutral protease from lysosomes of rabbit polymorphonuclear leucocytes. Biochem. J. 123, 559–569 (1971)

    PubMed  CAS  Google Scholar 

  • Davis, A.T., Estensen, R., Quie, P.G.: Cytochalasin B. III. Inhibition of human polymorphonuclear leucocyte phagocytosis. Proc. Soc. exp. Biol. (N.Y.) 137, 161–165 (1971)

    CAS  Google Scholar 

  • Dewald, B., Rindler-Ludwig, R., Bretz, U., Baggiolini, M.: Subcellular localization and heterogeneity of neutral proteases in neutrophilic polymorphonuclear leucocytes. J. exp. Med. 141, 709–723 (1975)

    PubMed  CAS  Google Scholar 

  • Dingle, J.T., Barrett, A.J., Poole, A.R., Stovin, P.: Inhibition by pepstatin of human cartilage degradation. Biochem. J. 127, 443–444 (1972)

    PubMed  CAS  Google Scholar 

  • Dingle, J.T., Barrett, A.J., Weston, P.D.: Cathepsin D. Characteristics of immuno-inhibition and the confirmation of a role in cartilage breakdown. Biochem. J. 123, 1–13 (1971)

    PubMed  CAS  Google Scholar 

  • Dingle, J.T., Fell, H.B., Coombs, R.R.A.: The breakdown of embryonic cartilage and bone cultivated in the presence of complement sufficient antiserum. II. Biochemical changes and the role of the lysosomal system. Int. Arch. Allergy 31, 283–303 (1967)

    PubMed  CAS  Google Scholar 

  • Dingle, J.T., Poole, A.R., Lazarus, G., Barrett, A.J.: Immunoinhibition of intracellular protein digestion in macrophages. J. exp. Med. 137, 1124–1141 (1973)

    PubMed  CAS  Google Scholar 

  • Estensen, R.D., Plageman, P.G.W.: Cytochalasin B inhibition of glucose and glucosamine transport. Proc. nat. Acad. Sci. (Wash.) 69, 1430–1434 (1972)

    CAS  Google Scholar 

  • Estensen, R.D., White, J.G., Holmes, B.: Specific degranulation of human polymorphonuclear leucocytes. Nature (Lond.) 248, 347–348 (1974)

    CAS  Google Scholar 

  • Fell, H.B., Barratt, M.E.J.: The role of soft connective tissue in the breakdown of pig articular cartilage cultivated in the presence of complement-sufficient antiserum to pig erythrocytes. I. Histological changes. Int. Arch. Allergy 44, 441–468 (1973)

    PubMed  CAS  Google Scholar 

  • Finlay, C., Davies, P., Allison, A.C.: Changes in cellular enzyme levels and the inhibition of selective release of lysosomal hydrolases from macrophages by indomethacin. Agents Actions 5, 345–353 (1975)

    PubMed  CAS  Google Scholar 

  • Folds, J.D., Welsh, I.R.H., Spitznagel, J.K.: Neutral protease confined to one class of lysosomes of human polymorphonuclear leucocytes. Proc. Soc. exp. Biol. (N.Y.) 139, 461–463 (1972)

    CAS  Google Scholar 

  • Fowler, S., DeDuve, C.: Digestive activity of lysosomes. III. The digestion of lipids by extracts of rat liver lysosomes. J. biol. Chem. 244, 471–481 (1969)

    PubMed  CAS  Google Scholar 

  • Ginsburg, I.: Mechanisms of cell and tissue injury induced by Group A streptococci: relation of poststreptococcal sequelae. J. infect. Dis. 126, 294–340, 419–456 (1972)

    PubMed  CAS  Google Scholar 

  • Goldstein, I.M., Brai, M., Osler, A.G., Weissmann, G.: Lysosomal enzyme release from human leucocytes: mediation by the alternate pathway of complement activation. J. Immunol. 111, 33–37 (1973a)

    PubMed  CAS  Google Scholar 

  • Goldstein, I.M., Hoffstein, S., Gallin, J., Weissmann, G.: Mechanism of lysosomal enzyme release from human leucocytes: microtubule assembly and membrane fusion induced by a component of complement. Proc. nat. Acad. Sci. (Wash.) 70, 2916–2920 (1973b)

    CAS  Google Scholar 

  • Goldstein, I.M., Hoffstein, S., Weissmann, G.: Mechanisms of lysosomal enzyme release from human polymorphonuclear leucocytes. Effects of phorbol myristate acetate. J. Cell Biol. 66, 647–652 (1975a)

    PubMed  CAS  Google Scholar 

  • Goldstein, I.M., Hoffstein, S., Weissman, G.: Influence of divalent cations upon complement-mediated enzyme release from human polymorphonuclear leucocytes. J. Immunol. 115, 665–670 (1975b)

    PubMed  CAS  Google Scholar 

  • Goldstein, I.M., Horn, J.K., Kaplan, H.B., Weissmann, G.: Calcium-induced lysozyme secretion from human polymorphonuclear leucocytes. Biochem. biophys. Res. Commun. 60, 807–812 (1974)

    PubMed  CAS  Google Scholar 

  • Goldstein, I.M., Weissmann, G.: Generation of C5-derived lysosomal enzyme-releasing activity (C5a) by lysates of leucocytes lysosomes. J. Immunol. 113, 1583–1588 (1974)

    PubMed  CAS  Google Scholar 

  • Gordon, S., Todd, J., Cohn, Z.A.: In vitro synthesis and secretion of lysozyme by mononuclear phagocytes. J. exp. Med. 139, 1228–1248 (1974b)

    PubMed  CAS  Google Scholar 

  • Gordon, S., Unkeless, J.C., Cohn, Z.A.: Induction of macrophage plasminogen activator by endotoxin stimulation and phagocytosis. Evidence for a two stage process. J. exp. Med. 140, 995–1010 (1974a)

    PubMed  CAS  Google Scholar 

  • Granger, G.A., Williams, T.: Lymphocyte cytotoxicity in vitro: activation and release of a cytotoxic factor. Nature (Lond.) 218, 1253–1254 (1968)

    CAS  Google Scholar 

  • Greenbaum, L.M.: Cathepsin D-generated, pharmacologically active peptides (leucokinins) and their role in ascites fluid accumulation. In: Reich, E., Rifkin, D.B., Shaw, E. (Eds.): Proteases and Biological Control, pp. 223–228. Cold Spring Harbor Laboratory 1975

    Google Scholar 

  • Harris, Jr., E.D., Reynolds, J.J., Werb, Z.: Cytochalasin B increases collagenase production by cells in vitro. Nature (Lond.) 257, 243–244 (1975)

    CAS  Google Scholar 

  • Hawkins, D.: Biopolymer membrane: a model system for the study of the neutrophilic leucocyte response to immune complexes. J. Immunol. 107, 344–352 (1971)

    PubMed  CAS  Google Scholar 

  • Hawkins, D.: Neutrophilic leucocytes in immunologic reactions in vitro: effect of cytochalasin B. J. Immunol. 110, 294–296 (1973)

    CAS  Google Scholar 

  • Hawkins, D., Peeters, S.: The response of polymorphonuclear leucocytes to immune complexes in vitro. Lab. Invest. 24, 483–491 (1971)

    PubMed  CAS  Google Scholar 

  • Henson, P.M.: Interaction of cells with immune complexes: adherence, release of constituents and tissue injury. J. exp. Med. 134, 114S-135S (1971a)

    PubMed  CAS  Google Scholar 

  • Henson, P.M.: The immunologic release of constituents from neutrophil leucocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles. J. Immunol. 107, 1535–1546 (1971b)

    PubMed  CAS  Google Scholar 

  • Henson, P.M.: The immunologic release of constituents from neutrophil leucocytes. II. Mechanisms of release during phagocytosis and adherence to nonphagocytosable surfaces. J. Immunol. 107, 1547–1557 (1971c)

    PubMed  CAS  Google Scholar 

  • Henson, P.M.: Pathologic mechanisms in neutrophil-mediated injury. Amer.J. Path. 68, 593–612 (1972)

    PubMed  CAS  Google Scholar 

  • Henson, P.M., Johnson, H.B., Spiegelberg, H.L.: The release of granule enzymes from human neutrophils stimulated by aggregated immunoglobulins of different classes and subclasses. J. Immunol. 109, 1182–1192 (1972)

    PubMed  CAS  Google Scholar 

  • Henson, P.M., Oades, Z.G.: Enhanced of immunologically induced granule exocytosis from neutrophils by cytochalasin B. J. Immunol. 110, 290–293 (1973)

    PubMed  CAS  Google Scholar 

  • Hoffstein, S., Weissmann, G.: Mechanism of lysosomal enzyme release from leucocytes. IV. Interaction of monosodium urate crystals with dogfish and human leucocytes. Arthr. Rheum. 18, 153–165 (1975)

    CAS  Google Scholar 

  • Holmsen, H., Day, H.J.: Thrombin-induced platelet release reaction and platelet lysosomes. Nature (Lond.) 219, 760–761 (1968)

    CAS  Google Scholar 

  • Huber, H., Polley, M.J., Linscott, W.D., Fudenberg, H.M., Müller-Eberhard, H.J.: Human monocytes: distinct receptor sites for the third component of complement and for immunoglobulin G. Science 162, 1281–1283 (1968)

    PubMed  CAS  Google Scholar 

  • Huber, H., Wagner, M.: Binding of immune complexes to human macrophages: the role of membrane receptor sites. In: Wagner, W.H., Hahn, H. (Eds.): Activation of Macrophages Workshop Conferences Hoescht, Vol. 2, pp. 54–62. Amsterdam: Excerpta Medica Foundation 1974

    Google Scholar 

  • Ignarro, L.J.: Dissimilar effects of antiinflammatory drugs on stability of lysosomes from peritoneal and circulating leucocytes and liver. Biochem. Pharmacol. 20, 2861–2870 (1971)

    PubMed  CAS  Google Scholar 

  • Ignarro, L.J., George, W.J.: Mediation of immunological discharge of lysosomal enzymes from human neutrophils by guanosine 3′5′-monophosphate. Requirement of calcium and inhibition by adenosine 3′,5′-monophosphate. J. exp. Med. 140, 225–238 (1974)

    PubMed  CAS  Google Scholar 

  • Ishikawa, H., Bischoff, R., Holtzer, H.: Formation of arrowhead complexes with heavy meromyosin in a variety of cells. J. Cell Biol. 43, 312–328 (1969)

    PubMed  CAS  Google Scholar 

  • Ishikawa, H., Smiley, J.D., Ziff, M.: Electron microscopic demonstration of immunoglobulin deposition in rheumatoid cartilage. Arthr. Rheum. 18, 563–576 (1975)

    CAS  Google Scholar 

  • Janoff, A.: Human granulocyte elastase. Further delineation of its role in connective tissue damage. Amer.J. Path. 68, 579–591 (1972)

    PubMed  CAS  Google Scholar 

  • Janoff, A., Blondin, J., Sandhaus, R.A., Mosser, A., Malemud, C.: Human neutrophil elastase: in vitro effects on natural substrates suggest important physiological and pathological actions. In: Reich, E., Rifkin, D.B., Shaw, E. (Eds.): Proteases and Biological Control, pp. 603–620. Cold Spring Harbor Laboratory 1975

    Google Scholar 

  • Janoff, A., Rosenberg, R., Galdston, M.: Elastase-like esteroprotease activity in human and rabbit alveolar macrophage granules. Proc. Soc. exp. Biol. (N.Y.) 136, 1054–1058 (1971)

    CAS  Google Scholar 

  • Kletzien, R.F., Perdue, J.F., Springer, A.: Cytochalasin A and B. Inhibition of sugar uptake in cultured cells. J. biol. Chem. 247, 2964–2966 (1972)

    PubMed  CAS  Google Scholar 

  • Koob, T.J., Jeffrey, J.J., Eisen, A.Z.: Regulation of human skin collagenase activity by hydrocortisone and dexamethasone in organ culture. Biochem. biophys. Res. Commun. 61, 1083–1088 (1974)

    PubMed  CAS  Google Scholar 

  • Lachmann, P.J., Coombs, R.R.A., Fell, H.B., Dingle, J.T.: The breakdown of embryonic (chick) cartilage and bone cultivated in the presence of complement-sufficient antiserum. III. Immunological analysis. Int. Arch. Allergy 36, 469–485 (1969)

    PubMed  CAS  Google Scholar 

  • Lazarus, G.S.: Studies on the degradation of collagen by collagenases. In: Dingle, J.T. (Ed.): Lysosomes in Biology and Pathology, pp. 338–364. Amsterdam-London: North Holland 1973

    Google Scholar 

  • Legrande, Y., Caen, J.P., Booyse, F.M., Rafelson, M.E., Robert, B., Robert, L.: Studies on a human blood platelet protease with elastolytic activity. Biochim. biophys. Acta 309, 406–413 (1973)

    Google Scholar 

  • Legrande, Y., Pignaud, G.: Human blood platelet elastase and proelastase. Path, et Biol. 23, 546–549 (1975)

    Google Scholar 

  • Lin, S., Santi, D.V., Spudich, J.A.: Biochemical studies on the mode of action of cytochalasin B. Preparation of [3H] cytochalasin B and studies on its binding to cells. J. biol. Chem. 249, 2268–2274 (1974)

    PubMed  CAS  Google Scholar 

  • Lockshin, M.D.: Normal macrophage migration inhibition in dexamethasone-treated guineapigs. Experientia (Basel) 28, 571–572 (1972)

    CAS  Google Scholar 

  • Malawista, S.E., Gee, J.B.L., Bensch, K.G.: Cytochalasin B reversibly inhibits phagocytosis; functional, metabolic and ultrastructural effects in human blood leucocytes and rabbit alveolar macrophages. Yale J. Biol. Med. 44, 286–300 (1971)

    PubMed  CAS  Google Scholar 

  • Marcus, A.J., Zucker-Franklin, D., Safier, L.B., Ullman, H.L.: Studies on human platelets and granules. J. clin. Invest. 45, 14–28 (1966)

    PubMed  CAS  Google Scholar 

  • Millroy, S.J., Poole, A.R.: Pig articular cartilage in organ culture. Effect of enzymatic depletion of the matrix on the response of chondrocytes to complement-sufficient antiserum against pig erythrocytes. Ann. rheum. Dis. 33, 500–508 (1974)

    PubMed  CAS  Google Scholar 

  • Mills, D.C.B., Robb, I.A., Roberts, G.C.K.: The release of nucleotides, 5-hydroxytryptamine and enzymes from human blood platelets during aggregation. J. Physiol. (Lond.) 195, 715–729 (1968)

    CAS  Google Scholar 

  • Mizel, S.B., Wilson, L.: Inhibition of the transport of several hex oses in mammalian cells by cytochalasin B. J. biol. Chem. 247, 4102–4105 (1972)

    PubMed  CAS  Google Scholar 

  • Müller-Eberhard, H.J.: Initiation of membrane attack by complement: assembly and control of C3 and C5. In: Reich, E., Rifkin, D.B., Shaw, E. (Eds.): Proteases and Biological Control, pp. 229–241. Cold Spr. Harb. Lab. 1975

    Google Scholar 

  • Nachman, R.L., Ferris, B.: Studies on human platelet protease activity. J. clin. Invest. 47, 2530–2540 (1968)

    CAS  Google Scholar 

  • Oronsky, A., Ignarro, L., Perper, R.: Release of cartilage mucopolysaccharide-degrading neutral protease from human leucocytes. J. exp. Med. 138, 461–472 (1973)

    PubMed  CAS  Google Scholar 

  • Page, R.C., Davies, P., Allison, A.C.: Effects of dental plaque on the production and release of lysosomal hydrolases by macrophages in culture. Arch, oral Biol. 18, 1481–1495 (1973)

    CAS  Google Scholar 

  • Page, R.C., Davies, P., Allison, A.C.: Pathogenesis of the chronic inflammatory lesion induced by Group A streptococcal cell walls. Lab. Invest. 30, 568–581 (1974a)

    PubMed  CAS  Google Scholar 

  • Page, R.C., Davies, P., Allison, A.C.: Participation of mononuclear phagocytes in chronic inflammatory diseases. J. reticuloendoth. Soc. 15, 413–438 (1974b)

    CAS  Google Scholar 

  • Pantalone, R.M., Page, R.C.: Lymphokine-induced production and release of lysosomal enzymes by macrophages. Proc. nat. Acad. Sci. (Wash.) 72, 2091–2094 (1975)

    CAS  Google Scholar 

  • Perper, R.J., Oronsky, A.L.: Enzyme release from human leucocytes and degradation of cartilage matrix. Effects of antirheumatic drugs. Arthr. Rheum. 17, 47–55 (1974)

    CAS  Google Scholar 

  • Poole, A.R., Barratt, M.E.J., Fell, H.B.: The role of soft connective tissue in the breakdown of pig articular cartilage cultivated in the presence of complement sufficient antiserum to pig erythrocytes. II. Distribution of immunoglobulin G (IgG). Int. Arch. Allergy 44, 469–488 (1973)

    PubMed  CAS  Google Scholar 

  • Poole, A.R., Hembry, R.M., Dingle, J.T.: Cathepsin D in cartilage: the immunohistochemical demonstration of extracellular enzyme in normal and pathological conditions. J. Cell Sci. 14, 139–161 (1974)

    PubMed  CAS  Google Scholar 

  • Reich, E.: Plasminogen activator—secretion by neoplastic cells and macrophages. In: Reich, E., Rifkin, D.B., Shaw, E. (Eds.): Proteases and Biological Control, pp. 333–341. Cold Spr. Harb. Lab. 1975

    Google Scholar 

  • Ringrose, P.S., Parr, M.A., McLaren, M.: Effects of anti-inflammatory and other compounds on the release of lysosomal enzymes from macrophages. Biochem. Pharmacol. 24, 607–614 (1975)

    PubMed  CAS  Google Scholar 

  • Robertson, P.B., Shru, K.W., Vail, M.S., Taylor, R.E., Fullmer, H.M.: Collagenase: demonstration in rabbit macrophages. J. dent. Res. 52, 189 (1973)

    Google Scholar 

  • Robertson, W., Van, Schwartz, B.: Ascorbic acid and the formation of collagen.J. biol. Chem. 201, 689–696 (1953)

    Google Scholar 

  • Ruddle, N.H., Waksman, B.H.: Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. II. Correlation of the in vitro response with skin reactivity. J. exp. Med. 128, 1255–1265 (1968)

    PubMed  CAS  Google Scholar 

  • Ruddy, S., Gigli, I., Austen, K.F.: The complement system of man. New Engl. J. Med. 287, 489–495, 545–549, 592–596, 642–646 (1972)

    PubMed  CAS  Google Scholar 

  • Schorlemmer, H.U., Allison, A.C.: Effects of activated complement components on enzyme secretion by macrophages. Immunology 31, 181–188 (1976)

    Google Scholar 

  • Schorlemmer, H.U., Davies, P., Allison, A.C.: Ability of achivated complement components to induce lysosomal enzyme release from macrophages. Nature (Lond.) 261, 48–49 (1976)

    CAS  Google Scholar 

  • Schwab, J.H., Cromartie, W.J., Robertson, B.S.: Identification of a toxic cellular component of Group A streptococci as a complex of group specific C-polysaccharide and A protein.J. exp. Med. 109, 43–54 (1959)

    PubMed  CAS  Google Scholar 

  • Senior, R.M., Bielefeld, D.R., Jeffrey, J.J.: Collagenolytic activity in alveolar macrophages. Clin. Res. 20, 88 (1972)

    Google Scholar 

  • Shevach, E.M., Jaffe, E.S., Green, I.: Receptors for complement and immunoglobulin on human and animal lymphoid cells. Transplant. Rev. 16, 3–28 (1973)

    PubMed  CAS  Google Scholar 

  • Shibata, N., Tatsumi, N., Tanaka, K., Okamura, Y., Senda, N.: A contractile protein possessing Ca sensitivity (natural actomyosin) from leucocytes. Its extraction and some of its properties. Biochim. biophys. Acta 256, 565–576 (1972)

    PubMed  CAS  Google Scholar 

  • Siegel, A., Liischer, E.F.: Non-identity of the α-granules of human blood platelets with typical lysosomes. Nature (Lond.) 215, 745–747 (1967)

    CAS  Google Scholar 

  • Snyderman, R., Shin, H.S., Dannenberg, A.M.: Macrophage proteinase and inflammation: the production of chemotactic activity from the fifth component of complement by macrophage proteinase. J. Immunol. 109, 896–898 (1972)

    PubMed  CAS  Google Scholar 

  • Spector, W.G., Heesom, N.: The production of granulomata by antigen-antibody complexes. J. Path. 98, 31–39 (1969)

    PubMed  CAS  Google Scholar 

  • Spencer, H.: Pathology of the Lung, 2nd Ed., pp. 434–471. London: Pergamon Press 1968

    Google Scholar 

  • Spitznagel, J.K., Dalldorf, F.G., Leffell, M.S., Folds, J.D., Welsh, J.R.H., Cooney, M.H, Martin, L.E.: Character of azurophil and specific granules purified from human polymorphonuclear leucocytes. Lab. Invest. 30, 774–785 (1974)

    PubMed  CAS  Google Scholar 

  • Spudich, J.A., Lin, S.: Cytochalasin B. Its interaction with actin and actomyosin from muscle. Proc. nat. Acad. Sci. (Wash.) 69, 442–446 (1972)

    CAS  Google Scholar 

  • Steinman, R.M., Cohn, Z.A.: The interaction of particulate horseradish peroxidase (HRP)-anti HRP immune complexes with mouse peritoneal macrophages in vitro. J. Cell Biol. 55, 616–634 (1972)

    PubMed  CAS  Google Scholar 

  • Stossel, T.P., Pollard, T.D.: Myosin in polymorphonuclear leucocytes. J. biol. Chem. 248, 8288–8294 (1973)

    PubMed  CAS  Google Scholar 

  • Temple, A., Loewi, G., Davies, P., Howard, A.: Cytotoxicity of immune guinea pig cells. II. The mechanism of macrophage cytotoxicity. Immunology 248, 655–670 (1973)

    Google Scholar 

  • Unkeless, J.C., Gordon, S., Reich, E.: Secretion of plasminogen activator by stimulated macrophages. J. exp. Med. 139, 834–850 (1974)

    PubMed  CAS  Google Scholar 

  • Wahl, L.M., Wahl, S.M., Mergenhagen, S.E., Martin, G.R.: Collagenase production by endotoxin-activated macrophages. Proc. nat. Acad. Sci. (Wash.) 71, 3598–3601 (1974)

    CAS  Google Scholar 

  • Wahl, L.M., Wahl, S.M., Mergenhagen, S.E., Martin, G.R.: Collagenase production by lympho-kine-activated macrophages. Science 187, 261–263 (1975)

    PubMed  CAS  Google Scholar 

  • Wannamaker, L.W., Matsen, J.M.: Streptococci and streptococcal diseases. New York: Academic Press 1972

    Google Scholar 

  • Ward, P.A., Hill, J.H.: C 5 chemotactic fragments produced by an enzyme in lysosomal granules of neutrophils. J. Immunol. 104, 535–543 (1970)

    PubMed  CAS  Google Scholar 

  • Wasserman, S.I., Goetzl, E.J., Austen, K.F.: Inactivation of slow reacting substance of anaphylaxis by eosinophil arylsulfatase. J. Immunol. 114, 645–649 (1975)

    PubMed  CAS  Google Scholar 

  • Weissmann, G.: The effects of steroids and drugs on lysosomes. In: Dingle, J.T., Fell, H.B. (Eds.): Lysosomes in Biology and Pathology, Vol. 1, pp. 276–298. London-Amsterdam: North Holland 1969

    Google Scholar 

  • Weissmann, G., Zurier, R.B., Spieler, P.T., Goldstein, I. M.: Mechanism of lysosomal enzyme release from leucocytes exposed to immune complexes and other particles. J. exp. Med. 134, 149 S-165 S (1971)

    CAS  Google Scholar 

  • Werb, Z., Gordon, S.: Secretion of a specific collagenase by stimulated macrophages. J. exp. Med. 142, 346–360 (1975a)

    PubMed  CAS  Google Scholar 

  • Werb, Z., Gordon, S.: Elastase secretion by stimulated macrophages. Characterization and regulation. J. exp. Med. 142, 361–377 (1975b)

    PubMed  CAS  Google Scholar 

  • Werb, Z., Reynolds, J.J.: Stimulation by endocytosis of the secretion of collagenase and neutral proteinase from rabbit synovial fibroblasts. J. exp. Med. 140, 1482–1497 (1974)

    PubMed  CAS  Google Scholar 

  • Wessels, N.K., Spooner, B.G., Ash, J.F., Bradley, M.D., Luduena, M.A., Taylor, E.L., Wrenn, J.T., Yamada, K.M.: Microfilaments in cellular and developmental processes. Science 171, 135–143 (1971)

    Google Scholar 

  • Weston, W.L., Mandel, M.J., Krueger, G.G., Claman, H.N.: Differential suppressive effect of hydrocortisone on lymphocytes and mononuclear macrophages in delayed hypersensitivity of guinea pigs. J. invest. Derm. 59, 345–348 (1972)

    PubMed  CAS  Google Scholar 

  • White, R.G., Estensen, R.D.: Selective labilization of specific granules in polymorphonuclear leucocytes by phorbol myristate acetate. Amer.J. Path. 75, 45–54 (1974)

    PubMed  CAS  Google Scholar 

  • Wright, D.G., Malawista, S.E.: Mobilization and extracellular release of granular enzymes from human leucocytes during phagocytosis: inhibition by colchicine and Cortisol but not by salicylate. Arthr. Rheum. 16, 749–758 (1973)

    CAS  Google Scholar 

  • Yang, Y.Z., Perdue, J.F.: Contractile proteins of cultured cells. I. The isolation and characterization of an actin-like protein from cultured chick embryo fiborblasts. J. biol. Chem. 247, 4503–509 (1972)

    CAS  Google Scholar 

  • Zigmond, S.H., Hirsch, J.G.: Cytochalasin B: inhibition of D-2-deoxyglucose transport into leucocytes and fibroblasts. Science 176, 1432–1434 (1972)

    PubMed  CAS  Google Scholar 

  • Zurier, R.B., Hoffstein, S., Weissmann, G.: Cytochalasin B: effect on lysosomal enzyme release from human leucocytes. Proc. nat. Acad Sci. (Wash.) 70, 844–848 (1973a)

    CAS  Google Scholar 

  • Zurier, R.B., Hoffstein, S., Weissmann, G.: Mechanisms of enzyme release from human leucocytes. I. Effect of cyclic nucleotides and colchicine. J. Cell Biol. 58, 27–41 (1973b)

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. P. Davies
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. C. Allison
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Wellcome Research Laboratories, Langley Court, Beckenham, Kent, BR3 3BS, UK

    John R. Vane

  2. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, CEP 14.100, São Paulo, Brazil

    Sergio H. Ferreira

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Davies, P., Allison, A.C. (1978). The Release of Hydrolytic Enzymes From Phagocytic and Other Cells Participating in Acute and Chronic Inflammation. In: Vane, J.R., Ferreira, S.H. (eds) Inflammation. Handbook of Experimental Pharmacology, vol 50 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66888-3_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-66888-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66890-6

  • Online ISBN: 978-3-642-66888-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation