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Inflammatory Mediators and Vascular Events

  • Chapter
Inflammation

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 50 / 1))

Abstract

The phenomena of the early stages of inflammation include obvious changes in the microcirculation. Most of the classic “cardinal signs” of acute inflammation can be ascribed to these microvascular changes. The redness and increase in local temperature reflect vasodilatation and consequent increase in blood flow; the swelling results from increased filtration of fluid due to increase in both the hydrostatic pressure within, and the permeability to macromolecules of, the small blood vessels. Another phenomenon, the invasion of the inflamed tissues by phagocytic cells from the circulating blood, also involves a change in the endothelial cells of the same vessels, leading to sticking and subsequent extravascular migration of leucocytes. These vascular events are observed in many different experimental forms of inflammation and represent an intrinsic part of the early inflammatory response. There is considerable evidence that some at least of these vascular phenomena of inflammation are mediated through endogenous chemical agents.

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Authors
  1. L. J. F. Youlten
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Editors and Affiliations

  1. The Wellcome Research Laboratories, Langley Court, Beckenham, Kent, BR3 3BS, UK

    John R. Vane

  2. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, CEP 14.100, São Paulo, Brazil

    Sergio H. Ferreira

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© 1978 Springer-Verlag Berlin Heidelberg

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Youlten, L.J.F. (1978). Inflammatory Mediators and Vascular Events. In: Vane, J.R., Ferreira, S.H. (eds) Inflammation. Handbook of Experimental Pharmacology, vol 50 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66888-3_17

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  • DOI: https://doi.org/10.1007/978-3-642-66888-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66890-6

  • Online ISBN: 978-3-642-66888-3

  • eBook Packages: Springer Book Archive

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