Effect of Extirpation of the Cervical Sympathetic Ganglia on Development of the Neurosecretory Peptidergic and Parvocellular Nuclei of Rat Hypothalamus During Postnatal Ontogenesis
Extirpation of the cervical sympathetic ganglia (CSG) results in retardation of the growth of young rats (EAYRS and TAYLOR, 1951; LEPEKHINA, 1975). Our purpose was to show the hypothalamic nuclei (supraoptic — SO, paraventricular — PV, suprachiasmatic — SCH, ventromedial — VM, dorsomedial — DM, arcuate — ARC) in which morphologic changes occur after extirpation of CSG in young rats, and to show how these changes are correlated with growth retardation. Twenty intact and twenty-six operated animals were studied during the course of 5 months of postnatal ontogenesis. A karyo- and cytometric study was made on the 10th, 20th, and 30th days after birth as well as at the ages of 2, 3, and 5 months. The results were treated statistically on the computer. Bilateral extirpation of the CSG was made within the first 5 days after birth.