Uric Acid pp 443-458 | Cite as

Pathology of Urate Nephropathy

  • J. H. Talbott
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 51)


Although urate nephropathy frequently is assumed to be synonymous with gouty kidney, there are certain objections to either term in this context. In the former the onus is placed solely upon the uric acid moiety for the nephropathy. Proof is lacking that this is always the fact. An objection to the implications of gouty kidney is its restricted sense, since in this discussion selected features beyond the kidney in patients with gout will be included. Furthermore, urates may not be demonstrated in the parenchyma of the kidney of many patients with gout, and the functioning units of the kidney may show alterations or changes not usually attributed to reactions either initiated or augmented by uric acid deposition. The focus of this discussion, however, will concern the kidney in gout, but other aspects including selected features of the transport of uric acid through the kidney will be considered briefly.


Uric Acid Serum Urate Gouty Arthritis Chronic Pyelonephritis Monosodium Urate 
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© Springer-Verlag Berlin Heidelberg 1978

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  • J. H. Talbott

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