Advertisement

Uric Acid pp 443-458 | Cite as

Pathology of Urate Nephropathy

  • J. H. Talbott
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 51)

Abstract

Although urate nephropathy frequently is assumed to be synonymous with gouty kidney, there are certain objections to either term in this context. In the former the onus is placed solely upon the uric acid moiety for the nephropathy. Proof is lacking that this is always the fact. An objection to the implications of gouty kidney is its restricted sense, since in this discussion selected features beyond the kidney in patients with gout will be included. Furthermore, urates may not be demonstrated in the parenchyma of the kidney of many patients with gout, and the functioning units of the kidney may show alterations or changes not usually attributed to reactions either initiated or augmented by uric acid deposition. The focus of this discussion, however, will concern the kidney in gout, but other aspects including selected features of the transport of uric acid through the kidney will be considered briefly.

Keywords

Uric Acid Serum Urate Gouty Arthritis Chronic Pyelonephritis Monosodium Urate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ball, G.V., Morgan, J.M.: Chronic lead ingestion and gout. South Med. J. 61, 21–24 (1968)CrossRefGoogle Scholar
  2. Barlow, K. A., Beilin, L. J.: Renal disease in primary gout. Quart. J. Med. 37, 79–96 (1968)PubMedGoogle Scholar
  3. Berger, L., Yü, T.F.: Renal function in gout. IV. An analysis of 524 gouty subjects including long term follow up studies. Amer. J. Med. 59, 605 (1975)PubMedCrossRefGoogle Scholar
  4. Deger, G.E., Wagoner, R.D.: Peritoneal dialysis in acute uric acid nephropathy. Mayo Clin. Proc. 47, 189–192(1972)PubMedGoogle Scholar
  5. Emmerson, B.T.: The clinical differentiation of lead gout from primary gout. Arthritis Rheum. 11, 623–634 (1968)PubMedCrossRefGoogle Scholar
  6. Emmerson, B.T., Mirosch, W., Douglas, J. B.: The relative contributions of tubular reabsorption and secretion to urate excretion in lead nephropathy. Aust. N.Z. J. Med. 4, 353–362 (1971)CrossRefGoogle Scholar
  7. Frei, E. III, Bentzel, C.J., Rieselbach, R., Block, J.B.: Renal complications of neoplastic disease. J. chron. Dis. 16, 757–776 (1963)PubMedCrossRefGoogle Scholar
  8. Gonick, H.C., Rubini, M.E., Gleason, I.O., Sommers, S.C.: The renal lesion in gout. Ann. intern. Med. 62, 667–674 (1965)PubMedGoogle Scholar
  9. Greenbaum, D., Ross, J.H., Steinberg, V.L.: Renal biopsy in gout. Brit. med. J. 1961 I, 1502–1504CrossRefGoogle Scholar
  10. Gudzent, F.: Gicht und Rheumatismus. Berlin: Springer 1928Google Scholar
  11. Heptinstall, R.H.: Pathology of the Kidney, pp. 495–506, 2nd Ed. Boston: Little Brown 1966Google Scholar
  12. Kjellstrand, C.M., Campbell, D.C., von Hartitzsch, B., Buselmeier, T.J.: Hyperuricemia acute renal failure. Arch, intern. Med. 133, 349–359 (1974)CrossRefGoogle Scholar
  13. Klinenberg, J.R., Bluestone, R., Schlosstein, L., Waisman, J., Whitehouse, M. W.: Urate deposition disease: how is it regulated and how can it be modified? Ann. intern. Med. 78, 99–111 (1973)PubMedGoogle Scholar
  14. Kröpelin, T., Mertz, D.P.: Zur Röntgendiagnostik der Gichtniere. Dtsch. med. Wschr. 97, 71–75 (1972)PubMedCrossRefGoogle Scholar
  15. Lesch, M., Nyhan, W.L.: A familial disorder of uric acid metabolism and central nervous system function. Amer. J. Med. 36, 561–570 (1964)PubMedCrossRefGoogle Scholar
  16. Lilis, R., Gavrilescu, N., Nestorescu, B., Dumitriu, C., Roventa, A.: Nephropathy in chronic lead poisoning. Brit. J. industr. Med. 25, 196–202 (1968)PubMedGoogle Scholar
  17. Mayne, J.G.: Pathological study of the renal lesion found in 27 patients with gout. Ann. rheum. Dis. 15, 61–62 (1955)Google Scholar
  18. Pardo, V., Perez-Stable, E., Fisher, E.R.: Ultrastructural studies in hypertension. III. Gouty nephropathy. Lab. Invest. 18, 143–150 (1968)PubMedGoogle Scholar
  19. Richet, P., Mignon, G. F., Ardaillou, R.: Gout secondary to chronic kidney disease (Fre). Presse med. 73, 633–638(1975)Google Scholar
  20. Rieselbach, R.E., Bentzel, C.J., Cotlove, E., Frei, E., Frereich, E.J.: Uric acid excretion and renal function in the acute hyperuricemia of leukemia: pathogenesis and therapy of uric acid nephropathy. Amer. J. Med. 37, 872–884 (1964)PubMedCrossRefGoogle Scholar
  21. Rundles, R.W., Wyngaarden, J.B., Hitchings, G.H., Elion, G.B., Silberman, H. R.: Effects of xanthine oxidase inhibitor on thiopurine metabolism, hyperuricemia, and gout. Trans. Ass. Amer. Physicians 76, 126–140 (1963)Google Scholar
  22. Schultz, A.: Zur Frage der Beziehungen zwischen Leukämie und Gicht. Zugleich Mitteilung histologischer Darstellungsmethoden der Harnsäure und der Urate. Virchows Arch. path. Anat. 280, 519–533 (1931)CrossRefGoogle Scholar
  23. Seegmiller, J.E., Frazier, P.D.: Biochemical considerations of the renal damage of gout. Ann. rheum. Dis. (Suppl.) 25, 668–672 (1966)Google Scholar
  24. Sokoloff, L.: The pathology of gout. Metabolism 6, 230–243 (1957)PubMedGoogle Scholar
  25. Sokoloff, L.: Pathology of gout. Arthritis Rheum. 8, 707–713 (1965)PubMedCrossRefGoogle Scholar
  26. Sorensen, L.B.: The pathogenesis of gout. Arch, intern. Med. 109, 379–390 (1962)Google Scholar
  27. Talbott, J.H.: Gout. New York: Oxford Univ. Pr. 1943Google Scholar
  28. Talbott, J.H.: Gout and blood dyscrasias. Medicine (Baltimore) 38, 173–205 (1959)Google Scholar
  29. Talbott, J.H.: Gout, 3rd Ed. New York: Grune and Stratton 1967Google Scholar
  30. Talbott, J. H., Terplan, K. L.: The kidney in gout. Medicine (Baltimore) 39, 405–462 (1960)Google Scholar
  31. Talbott, J.H., Yü, T.F.: Gout and Uric Acid Metabolism. New York: Stratton Intercon 1976Google Scholar
  32. Traut, E. F., Knight, A.A., Szanto, P.M., Passerelli, E. W.: Specific vascular changes in gout. J. Amer. med. Ass. 156, 591–593 (1954)Google Scholar
  33. Yü, T.F., Berger, L.: Renal disease in primary gout; a study of 253 gout patients with proteinuria. Semin. Arthritis Rheum. 4, 293–307 (1975)PubMedCrossRefGoogle Scholar
  34. Yü, T.F., Weinreb, N., Wittman, R., Wasserman, L.R.: Secondary gout associated with chronic myeloproliferative disorders. Semin. Arthritis Rheum. 5, 247–257 (1976)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • J. H. Talbott

There are no affiliations available

Personalised recommendations