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Pharmacology of Streptokinase

  • Chapter
Fibrinolytics and Antifibrinolytics

Abstract

As early as 1933, β-hemolytic streptococci were found to secrete into the culture medium a substance able to dissolve fibrin clots (Tillet and Garner, 1933). Since this substance, now known as streptokinase, represented a potential thrombolytic agent, the possibility of its use in human therapy attracted growing interest. In the early sixties, following extensive studies in this field, streptokinase was isolated in a highly purified form that was suitable for therapeutic use (for review see Markwardt et al., 1972; Brogden et al., 1973).

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  1. H.-P. Klöcking
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  1. Institut für Pharmakologie und Toxikologie, Medizinische Akademie Erfurt, Nordhäuser Straße 74, Erfurt, German Democratic Republic

    F. Markwardt

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Klöcking, HP. (1978). Pharmacology of Streptokinase. In: Markwardt, F. (eds) Fibrinolytics and Antifibrinolytics. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66863-0_6

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