Mechanisms of Lymphocyte Transformation

  • R. L. O’Brien
  • J. W. Parker
  • J. F. P. Dixon
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 6)


The sequence of events during which small lymphocytes undergo morphologic and metabolic changes culminating in the expression of differentiated functions and in cellular proliferation in response to various stimuli has been the subject of intensive research by investigators during the past fifteen years. This process, called lymphocyte transformation, mitogenesis, blastogenesis, lymphocyte activation, or lymphocyte stimulation, has served as a model for the study of controlled cellular proliferation, of the expression of differentiated immunologic functions, for biochemical studies of normal lymphoid cells, and for the in vitro study of immune functions and interactions between various cell types involved in the immune response.


Human Lymphocyte Lymphocyte Activation Lymphocyte Stimulation Human Peripheral Blood Lymphocyte Lymphocyte Transformation 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1978

Authors and Affiliations

  • R. L. O’Brien
  • J. W. Parker
  • J. F. P. Dixon

There are no affiliations available

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