DNA Replication—Bacteriophage Lambda

  • Anna Marie Skalka
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 78)


The last thorough review of λ DNA replication was written by Dale Kaiser for the “Lambda Book” in 1971. At this time most of the phage functions (e.g., N, O and P) and some of the bacterial functions (e.g., dnaR) essential for λ replication had been identified. Many structural details concerning circle replication had been elucidated and its origin and bidirectional nature determined electron microscopically. The reader is referred to that article for details and references to the earlier studies on which this knowledge was based. The ensuing years have provided a fuller understanding of many aspects of replication first alluded to in that review, some of them summarized in a general context by Yarmolinsky (1975). This chapter summarizes the basic findings since that time, with particular emphasis on the relationship between early (circle) and late (rolling circle) λ replication, a topic that has been central to the interest of our laboratory for the past several years.


Cold Spring Harbor Bacteriophage Lambda Replication Complex Rolling Circle Lytic Cycle 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • Anna Marie Skalka
    • 1
  1. 1.Roche Institute of Molecular BiologyNutleyUSA

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