Abstract
Ergot alkaloids became known to influence pituitary hormone secretion by the work of the reproduction physiologist Shelesnyak of the Weizmann Institute of Science, Rehovot, Israel. In the early 1950’s, in search of a pharmacologic tool which would interfere with the process of the uterine deciduoma reaction connected with ovum implantation, he applied the ocytocic ergometrine and ergotoxine to rats. Ergotoxine (Shelesnyak, 1954a) but not ergometrine (Shelesnyak, 1954b) inhibited the deciduoma reaction of the pseudopregnant rat, and Shelesnyak (1954a) concluded from his observations and a critical appraisal of the scanty information in the literature, that ergotoxine acts via the hypothalamus and pituitary to inhibit mammotrophin-luteotrophin (= prolactin) secretion. Thus, an entirely new field opened to ergot pharmacology at the time when the concept of hypothalamo-hypophyseal interplay just became generally accepted (Harris, 1955). It was not until 17 years later that the first clinical results indicating the suppression of prolactin secretion in man by an ergot alkaloid (CB 154, bromocriptine) were published (Lutterbeck et al., 1971).
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Flückiger, E., del Pozo, E. (1978). Influence on the Endocrine System. In: Berde, B., Schild, H.O. (eds) Ergot Alkaloids and Related Compounds. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66775-6_9
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