Advertisement

Meaning of the Type I Cell for the Chemoreceptive Process – An Electrophysiological Study on Cultured Type I Cells of the Carotid Body

  • H. Acker
  • F. Pietruschka

Abstract

The carotid body as a chemoreceptor is able to transduce changes of PO2, PCO2 and pH into nerve impulses. Several elements in the carotid body can be responsible for this process: type I cells, type II cells, small nerve fibers, and mitochondrial bags. We have started to investigate, by intracellular measurements, the electrophysiological characteristics of type I cells and their dependence on changes of PO2 to determine their role in the chemoreceptive mechanism. The measurements were done on cultured type I cells, as described by Pietruschka (2,3). These measurements on cultured cells have the following advantages:1 it is always possible to identify the cell to be punctured; and 2 because the cells are cultured in a monolayer, PO2 gradients can be neglected, and a direct correlation between changes in PO2 and electrophysiological parameters can be established. The disadvantage of this method is that the growing cells are very flat, and it is extremely difficult to puncture them.

Keywords

Membrane Potential Carotid Body Input Resistance Membrane Resistance Glomus Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

references

  1. 1.
    Baron, M., Eyzaguirre, C.: J. Neurobiol. 6, 521–527 (1975)CrossRefGoogle Scholar
  2. 2.
    Pietruschka, F.: Cell Tissue Res. 151, 317–321 (1974)CrossRefGoogle Scholar
  3. 3.
    Pietruschka, F., Acker, H., Gattermann, S., Seidl, E., Lubbers, D.W.: Arzneim. Forsch. 23 (No. 11), 1610 (1973)Google Scholar
  4. 4.
    Sampson, S.R.: in: The Peripheral Arterial Chemoreceptors. Purves, M.J. (ed.). London: Cambridge U. Pr. 1975, pp. 207–220Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1977

Authors and Affiliations

  • H. Acker
  • F. Pietruschka

There are no affiliations available

Personalised recommendations