Oxygen Binding to Haemocyanin: A Tentative Analysis in the Framework of a Concerted Model
In the last ten years several allosteric models (Monod et al., 1965; Koshland et al., 1966; Perutz, 1970), have been proposed in order to provide a description of the cooperative phenomena present in the ligandbinding curves of functioning proteins with complex quaternary structure. The principal distinction among the various models is the different relevance given to the conservation of symmetry at the level of quaternary structure in the low affinity (T) and high affinity (R) states: in one of the possible cases this principle is the most powerful constraint (concerted models), while in the other it is completely absent (sequential models). More recently a number of refinements as well as generalizations have been proposed, largely with the purpose to describe, within a comprehensive framework, the experimental data available for different systems (Wyman, 1969; Colosimo et al., 1976).
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