Influence of Parenteral Nutrition on Nitrogen Balance and Intracellular Amino Acid Pattern in Muscle Tissue of Patients Undergoing Surgery for Neoplasms of the Colon
A prominent feature of acute surgical catabolism is a negative nitrogen balance with protein breakdown and increased urea synthesis and excretion. Despite the repeated confirmation of these findings since first being reported in 1930 by CUTHBERTSON (5), the underlying mechanism and physiological signifcance remain obscure. It has been suggested that the muscle protein breakdown is accelerated after operations and that this is mainly the reason for the increased nitrogen excretion.
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