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The Autoantigen Determinants I/i, Pr1–3 of Normal and Leukemic Leucocytes

  • H. P. Geisen
  • D. Dörken
  • V. Lenhard
  • D. Roelcke
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 20)

Abstract

Cold agglutinins (CA) are autoantibodies with a temperature optimum of 0°C directed against erythrocytes (for review see 19). CA are directed against two different antigen complexes. The I/i-system was detected in 1956 by Wiener et al. (30) and in 1959 by Marsh and Jenkins (13). A broad spectrum of I- and i-determinants was immunochemically characterized by Feizi and Kabat (5). The Pr- (HD-) complex was detected in 1969 by Roelcke (17). The Pr-determinants are determined by N-acetylneuraminic acid (NANA) (17,18). The subspecificities Pr1, Pr2 and Pr3 were identified using human erythrocyte glycoproteins modified with regard to their terminal neuraminyl-groups (2, 20).

Keywords

Chronic Lymphocytic Leukemia Blood Group Cold Agglutinin Agglutination Titer Cold Agglutinin Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Chodirker, W.B., Bock, G.N., and Vaughan, J.H.: Isolation of human PMN leucocytes and granules: Observations on early blood dilution and on heparin. J. Lab. Clin. Med. 71, 9 (1968)PubMedGoogle Scholar
  2. 2.
    Ebert, W., Metz, J., and Roelcke, D.: Modifications of N-acetylneuraminic acid and their influence on the antigen activity of erythrocyte glycoproteins. Europ. J. Biochem. 27, 470 (1972)PubMedCrossRefGoogle Scholar
  3. 3.
    Feizi, T., Kabat, E.A., Vicari, G., Anderson, B., and Marsh, W.L.: Immunochemical studies on blood groups. XLIV. The I antigen complex: Specificity differences among anti-I sera revealed by quantitative preciptitin studies. Partial structure of the I determinant specific for one anti-I serum. J. Immunol. 106, 1578 (1971)PubMedGoogle Scholar
  4. 4.
    Feizi, T., Kabat, E.A., Vicari, G., Anderson, B., and Marsh, W.L.: Immunochemical studies on blood groups. XLVII. The I antigen complex-precursors in the A, B, H, Lea and Leb blood group system-hemagglutination — inhibition studies. J. exp. Med. 133, 39 (1971)PubMedCrossRefGoogle Scholar
  5. 5.
    Feizi, T., and Kabat, E.A.: Immunochemical studies on blood groups. LIV. Classification of anti-I and anti-i sera into groups based on reactivity patterns with various antigens related to the blood group A, B, H, Lea, Leb and precursor substances. J. exp. Med. 135, 1247 (1972)PubMedCrossRefGoogle Scholar
  6. 6.
    Feizi, T., Turberville, C, and Westwood, J.H.: Blood-Group Precursors And Cancer-Related Antigens. The Lancet 30, 391 (1975)CrossRefGoogle Scholar
  7. 7.
    Geisen, H.P., Roelcke, D., Rehn, K., and Konrad, G.: Hochtitrige Kälteagglutinine der Spezifität Anti-Pr nach Rötelninfektion. Klin. Wschr. 53, 767 (1975)PubMedCrossRefGoogle Scholar
  8. 8.
    Geisen, H.P., Lenhard, V., Roelcke, D., and Schmidt, W.: Nachweis von I/i- und Pr-Antigenen auf Lymphozyten durch Kälteagglutinine. Z. Immun.-Forsch.: in pressGoogle Scholar
  9. 9.
    Kathan, R.H., and Adamany, A.: Comparison of human MM, NN and MN blood group antigens. J. Biol. Chem. 242, 1716 (1967)PubMedGoogle Scholar
  10. 10.
    Kornfeld, R., and Kornfeld, S.: The structure of a phytohemagglutinin receptor site from human erythrocytes. J. Biol. Chem. 245, 2536 (1970)PubMedGoogle Scholar
  11. 11.
    Lalezari, P., and Murphy, G.B.: In: Histocompatibility Testing, p. 421, Munksgaard, Copenhagen, (1967)Google Scholar
  12. 12.
    Lalezari, P.: Agglutination of leucocytes by the polybrene technique. Manual of Tissue typing techniques p. 3, DHEW Publication No. (NIH) 74–545 (1973)Google Scholar
  13. 13.
    Marsh, W.L., Jenkins, W.J.: Anti-i: a new cold antibody. Nature (London) 188,753 (1960)CrossRefGoogle Scholar
  14. 14.
    Pruzanski, W., Farid, N., Keystone, E., and Armstrong, M.: The influence of homogeneous cold agglutinins on polymorphonuclear and mononuclear phagocytes. Clin. Immunol. Immunopathol. 4, 277 (1975)PubMedCrossRefGoogle Scholar
  15. 15.
    Pruzanski, W., Farid, N., Keystone, E., Armstrong, M., and Greaves, M.F.: The influence of homogeneous cold agglutinins on human B and T lymphocytes. Clin. Immunol. Immunopathol. 4, 248 (1975)PubMedCrossRefGoogle Scholar
  16. 16.
    Roelcke, D., and Dorow, W.: Besonderheiten der Reaktionsweise eines mit Plasmocytom-γA-Paraprotein identischen Kälteagglutinins. Klin. Wschr. 46, 126 (1968) f.PubMedCrossRefGoogle Scholar
  17. 17.
    Roelcke, D.: A new serological specificity in cold antibodies of high titer: anti-HD. Vox Sang. 16, 76 (1969)PubMedCrossRefGoogle Scholar
  18. 18.
    Roelcke, D.: Specificity of IgA cold agglutinins: anti-Pr1. Europ. J. Immunol. 3, 206(1973)CrossRefGoogle Scholar
  19. 19.
    Roelcke, D.: Cold agglutination. Antibodies and antigens. Clin. Immunol. Immunopathol. 2, 266 (1974)PubMedCrossRefGoogle Scholar
  20. 20.
    Roelcke, D., Ebert, W., and Geisen, H.P.: Anti-Pr3: Serological and Immunochemical Identification of a New Anti-Pr Subspecificity. Vox Sang. 30, 122 (1976)PubMedCrossRefGoogle Scholar
  21. 21.
    Shumak, K.H., Rachkewich, R.A., Crookston, M.C., and Crookston, G.A.: Antigens of the Ii system on lymphocytes. Nature New Biol. 231, 148 (1971)PubMedGoogle Scholar
  22. 22.
    Shumak, K.H., Rachkewich, R.A., and Greaves, M.F.: I and i antigens on normal human T and B lymphocytes and on lymphocytes from patients with chronic lymphocytic leukemia. Clin. Immunol. Immunopathol. 4, 241 (1975)PubMedCrossRefGoogle Scholar
  23. 23.
    Springer, G.F., Nagai, Y., and Tegtmeyer, H.: Isolation and properties of human blood-group NN and meconium-Vg antigens. Biochem. 5, 3254 (1966)CrossRefGoogle Scholar
  24. 24.
    Springer, G.F., and Desai, P.R.: Depression of Thomsen-Friedenreich (Anti-T) Antibody in Humans with Breast Carcinoma. Naturwissenschaften 62, 302 (1975)PubMedCrossRefGoogle Scholar
  25. 25.
    Springer, G.F., and Desai, P.R.: Human blood group MN and precursor specificities: Structural and biological aspects. Carbohydrate Res. 40, 183 (1975)CrossRefGoogle Scholar
  26. 26.
    Thomas, D.B., and Winzler, R.J.: Oligosaccharides from active sialoglycopeptides of human erythrocytes. Biochem. Biophys. Res. Commun. 35, 811 (1969)PubMedCrossRefGoogle Scholar
  27. 27.
    Thomas, D.B., and Winzler, R.J.: Structure of glycoproteins of human erythrocytes. Alkali-stable oligosaccharides. Biochem. J. 124, 55 (1971)PubMedGoogle Scholar
  28. 28.
    Thomas, D.B.: Antibodies specific for human T lymphocytes in cold agglutinin and lymphocytotoxic sera. Eur. J. Immunol. 3, 824 (1973)PubMedCrossRefGoogle Scholar
  29. 29.
    Thomas, D.B.: The i antigen complex: a new specificity unique to dividing human cells. Eur. J. Immunol. 4, 819 (1974)CrossRefGoogle Scholar
  30. 30.
    Wiener, A.S., Unger, L.J., Cohen, L., and Feldmann, J.: Type-specific cold autoantibodies as a cause of acquired hemolytic anemia and hemolytic transfusion reactions: biologic test with bovine red cells. Ann. intern. Med. 44, 221 (1956)PubMedGoogle Scholar
  31. 31.
    Winzler, R.J.: In: Glycoproteins: their composition, structure and function. Part B, p. 1268, Elsevier, Amsterdam, London, New York (1972)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • H. P. Geisen
    • 1
    • 2
  • D. Dörken
    • 1
    • 2
  • V. Lenhard
    • 1
    • 2
  • D. Roelcke
    • 1
    • 2
  1. 1.Institute of Immunology and SerologyUniversity of HeidelbergGermany
  2. 2.Medical University ClinicHeidelbergGermany

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