The Autoantigen Determinants I/i, Pr1–3 of Normal and Leukemic Leucocytes

  • H. P. Geisen
  • D. Dörken
  • V. Lenhard
  • D. Roelcke
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 20)


Cold agglutinins (CA) are autoantibodies with a temperature optimum of 0°C directed against erythrocytes (for review see 19). CA are directed against two different antigen complexes. The I/i-system was detected in 1956 by Wiener et al. (30) and in 1959 by Marsh and Jenkins (13). A broad spectrum of I- and i-determinants was immunochemically characterized by Feizi and Kabat (5). The Pr- (HD-) complex was detected in 1969 by Roelcke (17). The Pr-determinants are determined by N-acetylneuraminic acid (NANA) (17,18). The subspecificities Pr1, Pr2 and Pr3 were identified using human erythrocyte glycoproteins modified with regard to their terminal neuraminyl-groups (2, 20).


Chronic Lymphocytic Leukemia Blood Group Cold Agglutinin Agglutination Titer Cold Agglutinin Disease 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • H. P. Geisen
    • 1
    • 2
  • D. Dörken
    • 1
    • 2
  • V. Lenhard
    • 1
    • 2
  • D. Roelcke
    • 1
    • 2
  1. 1.Institute of Immunology and SerologyUniversity of HeidelbergGermany
  2. 2.Medical University ClinicHeidelbergGermany

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