Skip to main content

Etiological, Clinical and Prognostic Significance of the T-B Immunological Classification of Primary Acute Lymphoid Leukemias and Non Hodgkin’s Lymphomas

  • Conference paper
Immunological Diagnosis of Leukemias and Lymphomas

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 20))

Abstract

The identification of immunological membrane markers on normal human mononuclear leukocytes has permitted their classification into a T (thymodependent) and a B (thymoindependent) lymphocyte group (2, 3, 19, 45, 47, 56, 57), as well as a third group “non-T non-B”, which includes monocytes (23) and other cells, the precise origin of which is still unclear (8).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aisenberg A.C. and Long J.C.: Lymphocyte surface characteristics in malignant lymphomas. Ann. J. Med., 58, 300 (1975).

    Article  CAS  Google Scholar 

  2. Aiuti F. et al.: Identification, enumeration and isolation of B and T lymphocytes from human peripheral blood. Report of W.H.O. I.A.R.C., sponsored Workshop on human B and T cells. Scand. J. Immunol., 3, 521, (1974), (London 15–17 July 1974).

    Article  Google Scholar 

  3. Belpomme D., Dantchev D., Du Rusquec E., Grandjon D., Huchet R., Pouillart P., Schwarzenberg L., Amiel J.L. and Mathé G.: T and B lymphocyte markers on the neoplastic cells of 20 patients with acute and 10 patients with chronic lymphoid leukemia. Biomedicine, 20, 109, (1974).

    PubMed  CAS  Google Scholar 

  4. Belpomme D., Dantchev D., Du Rusquec E., Grandjon D., Huchet R., Pinon F., Pouillart P., Schwarzenberg L., Amiel J.L. and Mathé G.: La nature T ou B des cellures néoplastiques des leucémies lymphoïdes. Bull. Cancer, 61, 387 (1974).

    PubMed  CAS  Google Scholar 

  5. Belpomme D., Dantchev D., Joseph R., Huchet R., Grandjon D., Santoro A. and Mathé G.: Further studies of acute and chronic leukemia T and B cell membrane markers and scanning electron microscopy. In: Current studies on standardization problems in clinical pathology, haematology and radiotherapy in Hodgkin’s disease, p. 143, Excerpta Médica, Amsterdam, ICS 348, (1975).

    Google Scholar 

  6. Belpomme D., Dantchev D., Joseph R., Santoro A., Feuilhade de Chauvin F., Grandjon D. and Mathé G.: Cell membrane markers of T and B lymphocytes and monocytes in leukemias and hematosarcomas. In: Biological characterization of human tumors, p. 298, Excerpta Médica, Amsterdam, ICS 375, (1976).

    Google Scholar 

  7. Belpomme D., Dantchev D., Joseph R., Santoro A., Feuilhade de Chauvin F., Lelarge N., Grandjon D., Pontvert D. and Mathé G.: Classification of leukemias and hematosarcomas based on cell membrane markers and scanning electron microscopy. In: Clinical Tumor Immunology, p. 131, eds. J. Wybran, Pergamon Press Oxford and New York, (1976).

    Google Scholar 

  8. Belpomme D., Joseph R. and Lelarge N.: Increase of null cells in patients submitted to long term active immunotherapy. Cancer Immunol. Immunoth., 1, 113 (1976).

    Google Scholar 

  9. Belpomme D., Lelarge N., Joseph R. and Mathé G.: An immunological classification of leukemias and hematosarcomas based on cell membrane markers with special reference to null cell disorders. Eur. J. of Cancer, (1976) (In press).

    Google Scholar 

  10. Belpomme D., Lelarge N., Feuilhade de Chauvin F., Joseph R. and Mathé G.: An immunological classification of leukemias and hematosarcomas based on cell membrane markers with special reference to null-cell disorders. In: Lymphocytes, Macrophages and Cancer, p. 98, (G. Mathé, I. Florentin, M.C. Simmler, eds), Springer Verlag, (1976).

    Google Scholar 

  11. Borella L. and Sen L.T.: Cell surface markers on lymphoblasts from acute lymphocytic leukemia. J. Immunol., 111, 1257, (1973).

    PubMed  CAS  Google Scholar 

  12. Brouet J.C., Valensi F., Daniel M.T., Flandrin G., Preud’Homme J.L., and Seligman M.: Immunological classification of acute lymphoblastic leukemias: Evaluation of its clinical significance in a hundred patients. British. J. of Haematology, 33, 319 (1976).

    Article  CAS  Google Scholar 

  13. Brouet J.C., Labaume S. and Seligman M.: Evaluation of T and B lymphocyte membrane markers in human non-Hodgkin malignant lymphomata. Br. J. Cancer, 31, 121, (1975).

    Google Scholar 

  14. Brouet J.C., Preud’Homme J.L., Flandrin G., Chelloul N. and Seligman M.: Membrane markers in “Histiocytic” lymphomas (Reticulin cell sarcomas). J. Natl. Cancer Inst., 56, 631, (1976).

    PubMed  CAS  Google Scholar 

  15. Braylan R.G., Jaffe E.S. and Berard C.W.: Malignant lymphomas: Current classification and new observations (Sommers S.C. ed) In: Pathology Annual, p. 213, 1975. New York Appleton Century Crofts, 1975.

    Google Scholar 

  16. Catovsky D., Goldman J.M., Okos A., Frisch B. and Galton D.A.G.: T lymphoblastic leukemia: a distinct variant of acute leukemia. Brit. Med. J., 2, 643, (1974).

    Article  PubMed  CAS  Google Scholar 

  17. Chin A.H., Saiki J.H., Trujillo J.M. and Williams R.C.: Peripheral blood T and B lymphocytes in patients with lymphoma and acute leukemia. Clin. Immunol. Immunopath., 1, 499, (1973).

    Article  CAS  Google Scholar 

  18. Davey R.R. and Gottlieb A.J.: Lymphocyte surface markers in acute lymphocytic leukemia. Am. J. of Clinic. Path., 62, 818, (1974).

    CAS  Google Scholar 

  19. Froland S. and Natvig J.B.: Surface-bound immunoglobulin as a marker of B lymphocytes in man. Nature (New Biol.), 234, 251, (1971).

    CAS  Google Scholar 

  20. Gajl-Peczalska K., Bloomfield C.D., Nesbit M.E. and Kersey J.K.: B-cell markers on lymphoblasts in acute lymphoblastic leukemia. Clin. Exp. Immunol., 17, 561, (1974).

    PubMed  CAS  Google Scholar 

  21. Gajl-Peczalska J., Bloomfield C.D., Coccia P.F., Sosin H., Brunning R.D., and Kersey J.H.: B and T-cell lymphomas analysis of blood and lymph nodes in 87 patients. The Am. J. of Med., 59, 674 (1975).

    Article  CAS  Google Scholar 

  22. Gross L.: Effect of thymectomy on development of leukemia in CH mice inoculated with “passage” virus. Proc. Soc. Exp. Biol. (NY), 100, 325, (1959).

    CAS  Google Scholar 

  23. Hainz H.: Human monocytes: distinct receptor sites for the third component and for immunoglobulin G. Science, 1662, 1281, (1968).

    Google Scholar 

  24. Hayhoe F.G. and Flemans R.: An atlas of haematological cytology, London, (1969) Wolfe Medical Books.

    Google Scholar 

  25. Jaffe E.S., Shevach E.M., Frank M.M., Veraud C.W. and Green I.: Nodular lymphoma: evidence for origin from follicular B-lymphocytes. New Engl. J. Med., 290, 813, (1974).

    Article  PubMed  CAS  Google Scholar 

  26. Johansson B., Klein E. and Haglund S.: Correlation between the presence of surface localized immunoglobulin (Ig) and the histological type of human malignant lymphomas. Clinical Immunol, and Immunoth., 5, 119, (1976).

    CAS  Google Scholar 

  27. Kaplan J., Mastrangelo R. and Peterson W.D.: Childhood lymphoblastic lymphoma, a cancer of thymus-derived lymphocytes. Cancer Research, 34, 521, (1974).

    PubMed  CAS  Google Scholar 

  28. Kersey J.H., Sabad A., Gajl-Peczalska K., Hallgren H.M., Yunis E.J. and Nesbit M.: Acute lymphoblastic leukemia cells with T (thymo-derived) lymphocyte markers. Science, 182, 1355, (1973).

    Article  PubMed  CAS  Google Scholar 

  29. Kersey J.H., Nesbit M.E., Luckasen H.R., Sabad A., Yunis E.J. and Gajl-Peczalska K.J.: Acute lymphoblastic leukemic and lymphoma cells with thymus derived (T) markers. Mayo Clinic Proc, 49, 584, (1974).

    CAS  Google Scholar 

  30. Kersey J., Nesbit M., Hallgrer H., Sabad A., Yunis E. and Gajl-Peczalska K.: Evidence for origin of certain childhood acute lymphoblastic leukemias and lymphomas in thymus derived lymphocytes. Cancer, 36, 1348, (1975).

    Article  PubMed  CAS  Google Scholar 

  31. Lennert K., Stein H., Kaiserling E.: Cytological and functional criteria for the classification of malignant lymphoma. Br. J. Cancer, suppl. 2, 31, 29, (1975).

    CAS  Google Scholar 

  32. Lukes R.J. and Collins R.D.: Immunologic characterization of human malignant lymphomas. Cancer, 34, 1488 (1974).

    Article  PubMed  Google Scholar 

  33. Mann R.B., Jaffe E.S., Braylan R.C., Egglaston J.C., Ransom L., Kize H. and Berard C.W.: Immunologic and morphologic studies of T cell lymphoma. Am. J. Med., 58, 307 (1975).

    Article  PubMed  CAS  Google Scholar 

  34. Mathé G., Pouillart P., Sterescu M., Amiel J.L., Schwarzenberg L., Schneider M., Hayat M., De Vassal F. and Jasmin C.: Sub-division of classical varieties of acute leukemia. Correlation with prognosis and cure expectancy. Europ. J. Clin. Biol. Res., 16, 554, (1971).

    Google Scholar 

  35. Mathé G., and Belpomme D.: T and B lymphocytic nature of leukemias and lymphosarcomas: a new but still uncertain parameter for their classification. Biomedicine, 20, 81, (1974).

    PubMed  Google Scholar 

  36. Mathé G., Belpomme D., Dantchev D., Pouillart P., Jasmin C., Misset J.L., Musset M., Amiel J.L., Schlumberger J.R., Schwarzenberg L., Hayat M., De Vassal F. and Lafleur M.: Immunoblastic acute lymphoid leukemia. Biomedicine, 20, 333, (1974).

    PubMed  Google Scholar 

  37. Mathé G., Belpomme D., Dantchev D., and Pouillart P.: Progress in the classification of lymphoid and/or monocytoid leukemias and of lympho and reticulosarcomas (non Hodgkin’s lymphomas). Biomedicine, 22, 177, (1975).

    PubMed  Google Scholar 

  38. Mathé G., Belpomme D., Dantchev D., Pouillart P., Schlumberger J.R., and Lafleur M.: Leukemic lymphosarcomas: respective prognosis of the three types: prolymphocytc, lymphoblastic (or lymphoblastoid) and immunoblastic. Blood Cells, 1, 25, (1975).

    Google Scholar 

  39. Mathé G., Belpomme D., Dantchev D., Khalil A., Afifi A.M., Taleb N., Pouillart P., Schwarzenberg L., Hayat M., De Vassal F., Jasmin C., Misset J.L. et Musset M.: Immunoblastic lymphosarcomas. A cytological and clinical entity? Biomedicine, 22, 473, (1975).

    PubMed  Google Scholar 

  40. Mathé G. and Rappaport H.: Histological and cytological typing of neoplastic diseases of haematopoietic and lymphoid tissues, W.H.O., Geneva, (1976).

    Google Scholar 

  41. Mathé G., De Vassal F., Delago M., Pouillart P., Belpomme D., Joseph R., Schwarzenberg L., Amiel J.L., Schneider M., Cattan A., Musset M., Misset J.L. and Jasmin C.: 1975 current results of the first 100 cytologically typed acute lymphoid leukemia submitted to BCG active immunotherapy. Cancer Immunol. Immunoth., 1, 77, (1976).

    Google Scholar 

  42. Misset J.L., Pouillart P., Amiel J.L., Schwarzenberg L., Hayat M., De Vassal F., Musset M., Belpomme D., Jasmin C., Albahary C., Depierre R. and Mathé G.: Combinaison d’adryamicine, de VM26, de cyclophosphamide et de prednisone (AVmCP) pour la chimiothérapie des lymphosarcomes et reticulosarcomes aux stades ou formes topographiques III et IV. Nle. Presse Médicale, 4, 3117, (1975).

    CAS  Google Scholar 

  43. Nathwani B.N., Kim H. and Rappaport H.: Malignant lymphoma, lymphoblastic. Cancer, 38, 964, (1976).

    Article  PubMed  CAS  Google Scholar 

  44. Peter C.R., Mackenzie M.R., Glassy F.J.: T or B cell origin of some non Hodgkin’s lymphomas. Lancet, 2, 686, (1974).

    Article  PubMed  CAS  Google Scholar 

  45. Preud’Homme J.L. and Seligmann M.: Surface bound immunoglobulins a cell marker in human proliferative diseases. Blood, 40, 777, (1972).

    PubMed  Google Scholar 

  46. Rappaport H., Winter W.J. and Hicks E.B.: Follicular lymphoma. A reevalution of its position in the scheme of malignant lymphoma, based on a survey of 253 cases. Cancer, 9, 792, (1956).

    Article  PubMed  Google Scholar 

  47. Ross G.D., Rabellino E.M., Polley M.J. and Grey H.M.: Combined studies of complement receptor and surface immunoglobulin bearing cells and sheep erythrocyte rosette forming cells in normal and leukemic human lymphocytes. J. Clin. Invest., 52, 377, (1973).

    Article  PubMed  CAS  Google Scholar 

  48. Schedel I., Fink P.C., Bodenberger H. and Deicher H.: Monoclonal lymphoid cell surface immunoglobulins with tumor-specific determinant in lymphosarcoma. Clin. Immunol. Immunopath., 5, 74, (1976).

    Article  CAS  Google Scholar 

  49. Seligman M., Preud’Homme J.L. and Brouet J.C.: B and T cell markers in human proliferative blood diseases and primary immunodeficiencies, with special reference to membrane bound immunoglobulins. Transpl. Rev., 16, 85, (1973).

    Google Scholar 

  50. Sen L. and Borella L.: Clinical importance of lymphoblasts with T markers in childhood acute leukemia. N. Engl. J. Med., 292, 828, (1975).

    Article  PubMed  CAS  Google Scholar 

  51. Smith J.L., Barker C.R., Klein G.P. and Collins R.D.: Characterization of malignant mediastinal lymphoid neoplasm (Sternberg sarcoma) as thymic in origin. The Lancet, i, 74, (1973).

    Article  Google Scholar 

  52. Stathopoulos G., Davies A.J.S., Papamichail M., Holborow E.J., and Wiltshaw E.: Origin of malignant cells in lymphoma apparently originating in anterior mediastinum. The Lancet, 1, 927, (1974).

    Article  CAS  Google Scholar 

  53. Stein H., Lennert K., Parwaresch M.R.: Malignant lymphomas of a cell type. Lancet, ii, 855, (1972).

    Article  Google Scholar 

  54. Sternberg C.: Leukosarcomatose und Myeloblastenleukämie. Brit. Path., 61, 75, (1916).

    Google Scholar 

  55. Tsukimoto I., Wong K.Y. and Lampkin B.C.: Surface markers and prognostic factors in acute lymphoblastic leukemia. N. Engl. J. Med., 294, 245, (1976).

    Article  PubMed  CAS  Google Scholar 

  56. Wilson J.D. and Nossal C.J.V.: Identification of human T and B lymphocytes in normal peripheral blood and in chronic lymphocytic leukemia. The Lancet, 2, 788, (1971).

    Article  CAS  Google Scholar 

  57. Wybran J., Carr M.C. and Fudenberg H.H.: The human rosette forming cells as a marker of population of thymus derived cells. J. Clin. Invest., 51, 2537, (1972).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1977 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Belpomme, D., Lelarge, N., Mathé, G., Davies, A.J.S. (1977). Etiological, Clinical and Prognostic Significance of the T-B Immunological Classification of Primary Acute Lymphoid Leukemias and Non Hodgkin’s Lymphomas. In: Thierfelder, S., Rodt, H., Thiel, E. (eds) Immunological Diagnosis of Leukemias and Lymphomas. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66639-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-66639-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08216-3

  • Online ISBN: 978-3-642-66639-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics