Abstract
From recent studies on in vitro reactions of lymphoid cells from children with acute lymphoblastic leukemia (ALL) it has become evident that in the bone marrow and in the peripheral blood of those patients two populations of lymphoid cells do exist: blast cells which — depending on the type of ALL — may or may not carry the typical markers of T- or B-lymphocytes [2, 5, 6, 8] and small lymphoid cells which have T- and B-cell markers in a proportion similar to that found in healthy individuals [2]. Essentially little, however, is known about the functional capacity of this latter group of cells. This study, therefore, was performed to define the peripheral blood (PB) lymphoid cells of patients with ALL on the basis of in vitro functions: spontaneous cell proliferation (S-CP), phytohemagglutinin-induced lymphocyte blast cell proliferation (PHA-CP) and lymphotoxin production (LT-Prod) by PHA-stimulated PB lymphoid cells.
This work was supported by grants from the “Kind Philipp Stiftung” and the “Deutsche Forschungsgemeinschaft — SFB 37”.
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References
Astaldi, G., Massimo, L., Airo, R., and Mori, P.G.: Phytohemagglutinin and Lymphocytes from Acute Lymphocytic Leukemia. Lancet I, 1265 (1966).
Borella, L. and Sen, L.: T- and B-Lymphocytes and Lymphoblasts in Untreated Acute Lymphocytic Leukemia. Cancer 34, 646 (1974).
Eife, R., Eife, G., August, C., Kuhre, W., Staehr-Johansen, K.: Lymphotoxin Production and Blast Cell Transformation by Cord Blood Lymphocytes: Dissociated Lymphocyte Function in Newborn Infants. Cellular Immunology 14: 435 (1974).
Greaves, M.F., and Brown, G.: Antisera to Acute Lymphoblastic Leukemia Cells. Clin. Immunol. Immunopathol. 4, 67 (1975).
Jose, D.G., Ekert, H., Colebatch, J., Waters, K., Wilson, F., and O’Keefe, D.: Immune Function at Diagnosis in Relation to Response to Therapy in Acute Lymphocytic Leukemia of Childhood. Blood 47, 1011 (1976).
Kersey, J., Nesbit, M., Hallgren, H., Sabat, A., Yunis, E., and Gajl-Peczalska, K.: Evidence for Origin of Certain Childhood Acute Lymphoblastic Leukemia and Lymphomas in Thymus-Derived Lymphocytes. Cancer 36, 1348 (1975).
Peter, H.H., Eife, R., and Kalden, J.R.: Spontaneous Cytotoxicity of Normal Human Lymphocytes Against a Human Melanoma Cell Line: A Phenomenon Due to a Lymphotoxin-Like Mediator. J. Immunol. 116: 342 (1976).
Sen, L. and Borella, L.: Clinical Importance of Lymphoblasts with T Markers in Childhood Acute Leukemia. N. Engl. J. Med. 292, 828 (1975).
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Eife, R., Kopecky, M., Lau, B., Janka, G., Haas, R., Lampert, F. (1977). In Vitro Functions of Lymphoid Cells in Untreated Childhood Acute Lymphoblastic Leukemia. In: Thierfelder, S., Rodt, H., Thiel, E. (eds) Immunological Diagnosis of Leukemias and Lymphomas. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66639-1_25
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DOI: https://doi.org/10.1007/978-3-642-66639-1_25
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