Abstract
In addition to its diagnostic application, the Ph1 chromosome has been used as a clonal marker for analysing haemopoietic stem cell development in man (8, 29). During these clinical studies it has become evident that the clinical presentation and course of CML is heterogeneous (reviewed in refs. 24, 3, 1). The disease often progresses into myeloid blast crisis (which resembles acute myeloid leukaemia, AML) and sometimes progresses into ‘lymphoid’ blast crisis (which resembles acute lymphoid leukaemia, ALL). It has also been observed recently that some Ph1 positive patients with ‘lymphoid’ involvement present in ‘lymphoid’ blast crisis and thus simulate common ALL (20, 1, 15), but the development of obvious myeloid involvement in these patients is also frequent (20, 15). Thus, this particular clinical syndrome with morphologically dissimilar leukaemic populations in the patient (which nevertheless carry the same clonal marker, the Ph1 chromosome) offers unique possibilities to analyse the interrelationship of lymphoid and myeloid leukaemias and their respective normal target cells.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Beard, M.E. J., Durrant, J., Catovsky, D, Wiltshaw, E., Amess, J.L., Brearley, R.L., Kirk, B., Wrigley, P.F.M., Janossy, G., Greaves, M.F., and Galton, D.A.G.: Blast crisis of chronic myeloid leukaemia. I. Presentation simulating acute lymphoid leukaemia. Brit. J. Haem. 34, 169, 1976.
Billing, R., Rafizadeh, B., Drew, I., Hartman, G., Gale, R. and Terasaki, P.: Human B lymphocyte antigens expressed by lymphocytic and myelocytic leukaemia cells. I. Detection by rabbit antisera. J. exp. Med. 144, 186 1976.
Boggs, D.R.: Hematopoietic stem cell theory in relation to possible lymphoblastic conversion of chronic myeloid leukemia. Blood 44, 449, 1974.
Brown, G., Capellaro, D. and Greaves, M.F.: Leukaemia associated antigens in man. J. Natl. Cancer Inst. 55, 1281, 1975.
Chang, L.M.S.: Development of terminal deoxynucleotidyl transferase activity in embryonic thymus gland. Biochem. Biophys. Res. Commun. 44, 124, 1971.
Coleman, M.S., Hutton, J.J., DeSimone, P.: Terminal deoxynucleotidyl transferase in human leukaemia. Proc. Natl. Acad. Sci. USA 71, 4404, 1974.
Ellis, R., Rapson, N. and Greaves, M.F.: Hexosaminidase isoenzyme activity in human leukaemia, submitted for publication.
Fialkow, P.J., Gartier, S.M. and Yoshida, A.: Clonal origin of chronic myelocytic leukaemia. Proc. Natl. Acad. Sci. USA 58, 1468, 1976.
Greaves, M.F.: Clinical applications of cell surface markers. Progr. Haematol. 9, 255, 1975
Greaves, M.F., de Cicco, D., and Janossy, G.: Membrane phenotypes of human leukaemic cells. In: Proc. of 16th Int. Congress of Haematology. North Holland Publishing Co., Amsterdam, 1977.
Greaves, MF. and Janossy, G.: Anti-human T cell sera. In: (Eds. Bloom, B. and David, J.) In vitro methods in cell mediated immunity. Academic Press, N.Y., 1976.
Janossy, G., Greaves, M.F., Revesz, T., Lister, T.A., Roberts, M., Durrant, J., Kirk, B., Catovsky, D. and Beard, M.E.J.: Blast crisis of chronic myeloid leukaemia. II. Cell surface marker analysis of ‘lymphoid’ and myeloid cases. Brit. J. Haemat. 34, 183, 1976.
Janossy, G., Greaves, M.F., Sutherland, R., Durrant, J. and Lewis, C.: Membrane phenotypes of acute ‘lymphoid’ and undifferentiated leukaemias: relationship to target cells and differentiation pathways. Leukaemia Res. 1, in press.
Janossy, G., Kulenkampff, J., Goldstone, A., Greaves, M.F. and Capellaro, D.: Quantitative analysis of p23, 30 (Ia-like) antigen on leukaemias and normal bone marrow, in preparation.
Janossy, G., Roberts, M. and Greaves, M.F.: Target cell in chronic myeloid leukaemia and its relationship to common ALL. Lancet, in press 1976.
Marmont, A.M. and Damasio, E.E.: The treatment of terminal metamorphosis of chronic granulocytic with corticosteroids and vincristine. Acta Haematol. 51, 1, 1973.
Mathe, G. and Seman, G.: Aspects Histologiques et Cytologiques des Leucemies et Hematosarcomes. Libraire Maloine S.A., Paris, p. 65, 1963.
McCaffrey, R., Harrison, T.A., Parkman, R. and Baltimore, D.: Terminal deoxynucleotidyl transferase activity in human leukaemic cells and in normal human thymocytes. New Engl. J. Med. 292, 775, 1975.
Moore, M.A.S.: Marrow culture — a new approach to classification of leukaemias. Blood Cells, 1, 149, 1975.
Peterson, L.C., Bloomfield, CD., and Brunning, R.D.: Blast crisis as an initial or terminal manifestation of chronic myeloid leukaemia. Amer. J. Med. 60, 209, 1976.
Revesz, T., Greaves, M.F., Capellaro, D. and Murray, R.K.: Differential expression of cell surface binding sites for cholera toxin in acute and chronic leukaemias. Brit. J. Haemat. 34, in press.
Roberts, M., Janossy, G. and Greaves, M.F.: Cross-absorption studies with anti-ALL serum in common ALL and Ph1 positive lymphoid’ blast crisis, in preparation.
Saffhill, R., Dexter, T.M., Muldal, S., Testa, N.G. Morris-Jones, P. and Joseph, A.: Terminal deoxynucleotidyl transferase in a case of Ph1 positive infant chronic myelogenous leukaemia. Brit. J. Cancer 33, 664, 1976.
Sandberg, A.A. and Hossfeld, D.K.: Chromosomal abnormalities in human neoplasia. Ann. Rev. Med. 21, 379, 1970.
Sarin, P.S., Anderson, P.N. and Gallo, R.C.: Terminal deoxynucleotidyl transferase activities in human blood leukocytes and lymphoblast cell lines: high levels in lymphoblast cell lines and in blast cells of some patients with CML in acute phase. Blood 47, 11, 1976.
Schlossman, S.F., Chess, L., Humphreys. R.E. and Strominger, J.L.: Distribution of la-like molecules on the surface of normal and leukaemic cells. Proc. Nat. Acad. Sci. USA 73, 1288, 1976.
Shaw, M.T., Bottomley, R.H., Grocea, P.N. and Nordquist, R.E.: Heterogeneity of morphological, cytochemical and cytogenetic features in the blastic phase of chronic granulocytic leukaemia. Cancer 35, 199, 1975.
Srivastava, B.I.S., Khan, S.A. and Henderson, E.S.: High terminal deoxynucleotidyl transferase activity in acute myelogeneous leukaemia. Cancer Res. 36, 3847, 1976.
Tough, I.M., Jacobs, P.L., Court-Brown, W.M., Baikie, A.G. and Williamson, E.R.D.: Cytogenetic studies on bone marrow in chronic myeloid leukaemia. Lancet i, 844, 1963.
Welsh, K.I., Turner, M.J.: Preparation of antisera specific for human B cells by immunization of rabbits with immune complexes. Tissue Antigens, in press.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Janossy, G., Greaves, M.F., Capellaro, D., Roberts, M., Goldstone, A.H. (1977). Membrane Marker Analysis of ‘Lymphoid’ and Myeloid Blast Crisis in PH1 Positive (Chronic Myeloid) Leukemia. In: Thierfelder, S., Rodt, H., Thiel, E. (eds) Immunological Diagnosis of Leukemias and Lymphomas. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66639-1_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-66639-1_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-08216-3
Online ISBN: 978-3-642-66639-1
eBook Packages: Springer Book Archive