Abuse of Non-Narcotic Analgesics

  • P. Kielholz
  • D. Ladewig
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 45 / 1)

Abstract

After reports had first been published from Switzerland referring to the abuse of antipyretic analgesics containing phenacetin (Kielholz, 1954; Horrisberger et al., 1958; Battegay, 1958) and to the possibility of a causal connection between such abuse and chronic renal diseases (Spühler and Zollinger, 1963), numerous authors subsequently drew attention to the problem of the misuse of non-narcotic analgesics (cf. Gsell et al., 1968). The misuse of non-narcotic analgesics may lead to genuine dependence (Eddy et al., 1965; Jaffe, 1970), which on theoretical grounds might be assigned to the barbiturate type of drug dependence. An enquiry which was carried out from 1955 to 1969 over the whole of Switzerland revealed that the number of first admittances to psychiatric hospitals of patients suffering from dependence on non-narcotic analgesics had trebled (Kielholz, 1968; Kielholz and Battegay, 1967). Evidence showed that the abuse of analgesics had increased not only in urban districts but also in rural areas. Although an initial enquiry undertaken over the period 1945–1954 (Müller and Kielholz, 1967; Ladewig, 1973) had disclosed that the abuse of analgesics was significantly higher among workers engaged in certain special occupations, such as the watch and textile industries, this difference later ceased to be significant. Patients dependent upon analgesics are predominantly women, the ratio of women to men being 4:1. The age at which the incidence is greatest (i.e., the so-called age of manifestation) is the same for both sexes, namely, 35–45 years. Compared with the normal population, such patients tend to be more frequently either divorced or unmarried.

Keywords

Migraine Anemia Diarrhea Caffeine Constipation 

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References

  1. Battegay, R.: Aktuelle Aspekte der Analgeticasucht. Nervenarzt 29, 467, (1958)PubMedGoogle Scholar
  2. Bucher, K.: Ursachen und Konsequenzen des Arzneimittelverbrauchs. Schweiz. Apoth.-Ztg. 100, 190, 1962Google Scholar
  3. Dubach, U.C.: Mortalitätsentwicklung für Nierenleiden in der Schweiz. Schweiz. med. Wschr. 40, 1542, (1968)Google Scholar
  4. Dubach, U.C., Minder, F., Gsell, O.: An Epidemiological Study of Analgesic Abuse, Proc. 3rd Int. Congr. Nephrol. Washington, p. 300 (1966). Basel-New York: S. Karger 1967Google Scholar
  5. Eddy, N.B., Halbach, H., Isbell, H., Seevers, M.H.: Drug dependence: Its significance and characteristics. Bull. WHO 37, (1965)Google Scholar
  6. Gilman, A.: Analgesic nephrotoxicity a pharmacological analysis. Amer. J. Med. 36, 167–173 (1964)PubMedCrossRefGoogle Scholar
  7. Gsell, O., Dubach, U.C., Raillard-Peucker, U.: Phenazetinabusus und Nierenleiden. Dtsch. med. Wschr. 94, 101 (1968)CrossRefGoogle Scholar
  8. Horrisberger, B., Grandjean, E., Lanz, F.: Untersuchungen über den Medikamentenmißbrauch in einem Großbetrieb der schweiz. Uhrenindustrie, Schweiz. med. Wschr. 88, 920 (1958)Google Scholar
  9. Jaffe, J.H.: Drug addiction and drug abuse. In: Goodman, L.S., Gilman, A. (Eds.): The Pharmacological Basis of Therapeutics, pp.276–313. London: Macmillan 1970Google Scholar
  10. Kielholz, P.: Aetiologie und Therapie der Analgetica-und Hypnoticasucht. Schweiz. med. Wschr. 84, 1214 (1954)Google Scholar
  11. Kielholz, P.: Gesamtschweizerische Enquête über die Häufigkeit des Medikamentenmißbrauchs, Bericht der von der Schweiz. Sanitätsdirektoren-Konferenz eingesetzten Kommission zur Behandlung des Problems des Medikamentenmißbrauchs. Schweiz. Ärzteztg. 49, 1077 (1968)Google Scholar
  12. Kielholz, P., Battegay, R.: Vergleichende Untersuchungen über die Genese und den Verlauf der Drogenabhängigkeit und des Alkoholismus. Schweiz. med. Wschr. 97, 893 (1967)PubMedGoogle Scholar
  13. Kielholz, P., Ladewig, D.: Arzneimittelmißbrauch. In: IKS (Eds.): Jubiläumsschrift zum 75jährigen Bestehen der interkantonalen Vereinbarung über die Kontrolle der Heilmittel, Bern 1975, pp.137–144Google Scholar
  14. Ladewig, D.: Gesamtschweizerische Enquête über die Häufigkeit des Medikamenten-und Drogenmißbrauchs. Schweiz. Ärzteztg. 28, 971–974 (1973)Google Scholar
  15. Ladewig, D., Dubach, U.C., Ehrensperger, Th., Hobi, V., Miest, P.: Epidemiologische, Psychiatrische und Psychol ogische Aspekte des Analgetika-Mißbrauchs. Beitr. Int. Symp. Probleme des Phenacetin-Abusus, Wien 1973. Facta Publication, Wien 1973, 275–286Google Scholar
  16. Müller, T., Kielholz, P.: Erhebung über Ausmaß, Verbreitung und Prophylaxe des Medikamenten-insbesondere des Analgeticmißbrauchs in der Schweiz. Bull. Eidg. Gesundheitsamt B 5 (1967)Google Scholar
  17. Spühler, O., Zollinger, H.U.: Die chronische interstitielle Nephritis. Z. klin. Med. 151, 1 (1963)Google Scholar
  18. Woodbury, D.M.: Analgesic-antipyretics, anti-inflammatory agents and inhibitors of uric acid synthesis. In: Goodman, L.S., Gilman, A. (Eds.): The Pharmacological Basis of Therapeutics, pp.314–347. London: Macmillan 1970Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • P. Kielholz
  • D. Ladewig

There are no affiliations available

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