The Polyunsaturated Fatty Acids in Human Platelets: Effects of Diet and Possible Functional Significance
A diet rich in saturated fats plus the addition of cholesterol, thiouracil, and cholic acid causes thrombosis in the rat (Thomas and Hartroft, 1959; Gresham and Howard, 1960; Renaud and Allard, 1962) and the thrombogenic effect of adenosine diphosphate is intensified by propylthiouracil added to a diet rich in saturated fats and cholesterol (Nordbøy and Chandler, 1964). A thrombogenic syndrome may be observed (Mustard et al., 1963) in pigs on a diet rich in saturated fats and cholesterol.
KeywordsCholesterol Adenosine Prostaglandin Oxane Phosphatidylcholine
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- Marks, P.A., Gellhorn, A., Kidson, C.J.: Biol. Chem. 235, 2579–2583 (1960)Google Scholar
- Mustard, J.F., Roswell, H.C., Murphy, E.A., Downie, H.G.: J. Clin. Invest. 42., 1783 (1963)Google Scholar
- Renaud, S., Kinlough, R., Mustard, J.F.: Lab. Invest. 22, 339–343 (1920)Google Scholar
- Schoene, N.W., Iacono, J.M.: Circulation 46, 11–32 (1973)Google Scholar