Abstract
It has become increasingly apparent that aspirin induces a marked delay in the aggregation properties of platelets. It causes an inhibition of collagen-induced platelet aggregation in association with and probably due to a decreased release of ADP. This occurs in vitro. The response of platelets to epinephrine-induced release of ADP in the second wave of aggregation is also blocked by aspirin. In addition, the drug inhibits both collagen and ADP-induced activation of platelet factor III (phospholipid-like factor) and the release of platelet factor IV in vitro and in vivo, but does not impair the response to thrombin. These effects are uniquely confined to aspirin, since sodium salicylate neither prolongs the bleeding time nor significantly inhibits platelet ADP release.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Boston Collaborative Drug Surveillance Group: Regular aspirin intake and acute myorcardial infarction. Brit. med. J. 1, 440–443 (1974)
Elwood, P.C., Cochrane, A.L., Burr, M.L., Sweetman, P.M., Williams, G., Welsby, E., Hughes, S.J., Renton, R.: A randomized controlled trial of acetyl salicylic acid in the secondary prevention of mortality from myocardial infarction. Brit. med. J. 1, 436–440 (1974)
Evans, G., Packham, M.A., Mustard, J.F.: Chapter VII, Thromboembolism. In: Aspirin, Platelets and Stroke. Fields, W.S., Hass, W.K. (eds.). St. Louis Mo.: Warren H. Green, Inc. 1970
Evans, G.: Effect of platelet-suppressive agents on the incidence of amaurosis fugax and transient cerebral ischemia. In: Cerebral Vascular Diseases. 8th Conference, McDowell, F.H., Brennan, R.W. (eds.). New York: Grune and Stratton 1973
Stuart, R.K.: Platelet function studies in human beings receiving 300 mg of aspirin per day. J. Lab. clin. Med. 75, 463–471 (1970)
Weiss, H.J., Danese, C.A., Voletti, C.D.: Prevention of experimentally induced arterial thrombosis by aspirin. Fed. Proc. 29, 381 (1970)
Zucker, M.B., Peterson, J.: Effect of acetylsalicylic acid, other nonsteroidal anti-inflammatory agents and dipyridamole on human blood platelets. J. Lab. clin. Med. 76, 66–75 (1970)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Fields, W.S., Callen, P.W., Preslock, M.M. (1977). Aspirin in Cerebral Ischemia. In: Agnoli, A., Fazio, C. (eds) Platelet Aggregation in the Pathogenesis of Cerebrovascular Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66609-4_32
Download citation
DOI: https://doi.org/10.1007/978-3-642-66609-4_32
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66611-7
Online ISBN: 978-3-642-66609-4
eBook Packages: Springer Book Archive