Antibody Affinity, Macrophage Function and Immunoregulation in Murine Immune Complex Disease

  • M. W. Steward
Conference paper
Part of the Bayer-Symposium book series (BAYER-SYMP, volume 6)


The investigation of experimentally-induced chronic immune complex disease (ICD) in rabbits receiving daily injection of heterologous serum protein antigens has shown that both quantitative and qualitative variations in antibody response underlie differences in susceptibility to this disease (3, 25). Furthermore, the observations that there are clear inter-strain differences in susceptibility to chronic ICD following neonatal infection of inbred mice with lymphocytic choriomeningitis virus (LCM) indicate that genetically determined factors may underlie these variations in antibody response (19).


Human Serum Albumin Macrophage Function Immunoglobulin Class Lymphocytic Choriomeningitis Virus Immune Complex Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Alpers, J.H., Steward, M.W., Soothill, J.F.: Differences in immune elimination in inbred mice. The role of low affinity antibody. Clin. exp. Immunol. 12, 121 (1972)PubMedGoogle Scholar
  2. 2.
    Burnett, F.M., Holmes, M.C.: Genetic investigations of autoimmune disease in mice. Nature (Lond.) 207, 368 (1965)CrossRefGoogle Scholar
  3. 3.
    Dixon, F.J., Feldman, J.D., Vasquez, J.J.: Experimental glomerulonephritis. J. exp. Med. 113, 899 (1961)PubMedCrossRefGoogle Scholar
  4. 4.
    East, J.: Immunopathology and neoplasms in New Zealand Black (NZB) and 5J1J mice. Progr. exp. Tumor Res. 13, 84 (1970)PubMedGoogle Scholar
  5. 5.
    East, J., Harvey, J.J.: Autoimmune haemolytic anaemia in New Zealand Black mice. Brit. J. Haemat. 31 (Suppl.), 37 (1975)Google Scholar
  6. 6.
    Gaze, S.E., West, N.J., Steward, M.W.: The use of a double isotope method in the determination of antibody affinity. J. immunol. Methods 3, 357 (1973)CrossRefGoogle Scholar
  7. 7.
    Hay, F.C., Torrigiani, G.: The effect of pertussis adjuvant on antibody production: the need for thymus dependent lymphocytes. Europ. J. Immunol. 3, 657 (1973)CrossRefGoogle Scholar
  8. 8.
    Helyer, B.J., Howie, J.B.: Renal disease associated with positive lupus erythematosus tests in a cross-bred strain of mice. Nature 197, 197 (1963)PubMedCrossRefGoogle Scholar
  9. 9.
    Howie, J.B., Helyer, B.J.: The immunology and pathology of NZB mice. Advanc. Immunol. 9, 215 (1968)CrossRefGoogle Scholar
  10. 10.
    Katz, F.E., Steward, M.W.: The genetic control of antibody affinity in mice. Immunology 29, 543 (1975)PubMedGoogle Scholar
  11. 11.
    Lambert, P.H., Dixon, F.J.: Pathogenesis of the glomerulonephritis of NZB/W mice. J. exp. Med. 127, 507 (1968)PubMedCrossRefGoogle Scholar
  12. 12.
    Levy, J.A.: Xenotropic viruses: murine leukaemia viruses associated with NIH, NZB and other mouse strains. Science 182, 1151 (1973)PubMedCrossRefGoogle Scholar
  13. 13.
    Mellors, R.C.: Autoimmune and immunoproliterative diseases of NZB/B1 mice and hybrids. Int. Rev. exp. Path. 5, 217 (1966)PubMedGoogle Scholar
  14. 14.
    Mellors, R.C, Huang, C.Y.: Immunopathology of NZB/BL mice. VI. Virus separable from spleen and pathogenic for Swiss mice. J. exp. Med. 126, 53 (1966)CrossRefGoogle Scholar
  15. 15.
    Mellors, R.C, Shirai, T., Aoki, R.J., Huebner, R.J., Kruwcyznski, K.: Wild type Gross leukemia virus and the pathogenesis of glomerulonephritis of NZ mice. J. exp. Med. 133, 113 (1971)PubMedCrossRefGoogle Scholar
  16. 16.
    Morgan, A.G., Soothill, J.F.: Measurement of the clearance function of macrophages with 123I-labeled polyvinyl pyrrolidone. Clin. exp. Immunol. 20, 489 (1975)Google Scholar
  17. 17.
    Morgan, A.G., Soothill, J.F.: Relationship between macrophage clearance of PVP and affinity of anti-protein antibody response in inbred mouse strains. Nature 254, 711 (1975)PubMedCrossRefGoogle Scholar
  18. 18.
    Morgan, A.G., Steward, M.W.: Macrophage clearance function and immune complex disease in New Zealand Black/White hybrid mice. Clin. exp. Immunol. 26, 133 (1976)PubMedGoogle Scholar
  19. 19.
    Oldstone, M.B.A., Dixon, F.J.: Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis virus. I. Relationship of antibody production of disease in neonatally infected mice. J. exp. Med. 129, 483 (1969)PubMedCrossRefGoogle Scholar
  20. 20.
    Passwell, J.H., Steward, M.W., Soothill, J.F.: Inter-mouse strain differences in macrophage function and its relationship to antibody responses. Clin. exp. Immunol. 17, 159 (1974)PubMedGoogle Scholar
  21. 21.
    Petty, R.E., Steward, M.W.: Relative affinity of anti-protein antibodies in New Zealand mice. Clin. exp. Immunol. 12, 343 (1972)PubMedGoogle Scholar
  22. 22.
    Petty, R.E., Steward, M.W.: The effect of immunological adjuvants on relative affinity of anti-protein antibodies. Immunology 32, 49 (1977)PubMedGoogle Scholar
  23. 23.
    Petty, R.E., Steward, M.W.: The relationship of antibody affinity to onset of immune complex disease in New Zealand mice. J. Rheumatic. Dis., in press (1977)Google Scholar
  24. 24.
    Petty, R.E., Steward, M.W., Soothill, J.E.: The heterogeneity of antibody affinity and its possible immunopathologic significance. Clin. exp. Immunol. 12, 231 (1972)PubMedGoogle Scholar
  25. 25.
    Pincus, T., Haberkern, R., Christian, C.L.: Experimental chronic glomerulitis. J. exp. Med. 127, 819 (1968)PubMedCrossRefGoogle Scholar
  26. 26.
    Soothill, J.F., Steward, M.W.: The immunopathological significance of the heterogeneity of antibody affinity. Clin. exp. Immunol. 9, 193 (1971)PubMedGoogle Scholar
  27. 27.
    Spiegelberg, H.L.: Biological activities of immunoglobulins of different classes and subclasses. Advanc. Immunol. 19, 259 (1974)CrossRefGoogle Scholar
  28. 28.
    Steinberg, A.D., Pincus, T., Talal, N.: DNA-binding assay for detection of anti-DNA antibodies in NZB/NZW F1 mice. J. Immunol. 102, 788 (1969)PubMedGoogle Scholar
  29. 29.
    Steward, M.W., Hay, F.C.: Changes in immunoglobulin class and subclass of anti DNA antibodies with increasing age in NZB/W F1 hybrid mice. Clin. exp. Immunol. 26, 363 (1976)PubMedGoogle Scholar
  30. 30.
    Steward, M.W., Petty, R.E.: The use of ammonium sulphate globulin precipitation for determination of the affinity of anti protein antibodies in mouse serum. Immunology 22, 747 (1972a)PubMedGoogle Scholar
  31. 31.
    Steward, M.W., Petty, R.E.: The antigen binding characteristics of antibody pools of different relative affinity. Immunology 23, 881 (1972b)PubMedGoogle Scholar
  32. 32.
    Steward, M.W., Petty, R.E.: Evidence for the genetic control of antibody affinity from breeding studies with inbred mouse strains producing high and low affinity antibody. Immunology 30, 789 (1976)PubMedGoogle Scholar
  33. 33.
    Steward, M.W., Gaze, S.E., Petty, R.E.: Low affinity antibody production in mice — a form of immunological tolerance? Europ. J. Immunol. 4, 751 (1974)CrossRefGoogle Scholar
  34. 34.
    Steward, M.W., Katz, F.E., West, N.J.: The role of low affinity antibody in immune complex disease; the quality of anti-DNA antibodies in NZB/W F1 hybrid mice. Clin. exp. Immunol. 21, 121 (1975)PubMedGoogle Scholar
  35. 35.
    Talal, N.: Disordered immunologic regulation and autoimmunity. Transplantation Reviews 31, 240 (1976)PubMedGoogle Scholar
  36. 36.
    Tonietti, G., Oldstone, M.B.A., Dixon, F.S.: The effect of induced chronic viral infections on the immunologic diseases of New Zealand mice. J. exp. Med. 132, 89 (1970)PubMedCrossRefGoogle Scholar
  37. 37.
    Torrigiani, G.: Quantitative estimation of antibodies in the immunoglobulin classes of the mouse. I. The effect of adjuvants on the antibody response to human serum albumin and keyhole limpet hemocyanin. Clin. exp. Immunol. 11, 125 (1972)PubMedGoogle Scholar
  38. 38.
    Yoshiki, T., Mellors, R.C., Strand, M., August, J.T.: The viral envelope glycoprotein of murine leukaemia virus and the pathogenesis of immune complex glomerulonephritis of New Zealand mice. J. exp. Med. 140, 1011 (1974)PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • M. W. Steward

There are no affiliations available

Personalised recommendations