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Protein-Protein Interactions and the Functional States of Sarcoplasmic Reticulum Membranes

  • A. Martonosi
  • H. Nakamura
  • R. L. Jilka
  • J. H. Vanderkooi
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Summary

Rapid kinetic and electron microscope observations suggest that cooperative phenomena play an important role in the mechanism of Ca transport and Ca release by sarcoplasmic reticulum. The observations are consistent with the occurrence of tetramers of Ca transport ATPase in the membrane in equilibrium with monomers and dimers.

Fluorescence energy transfer between ATPase molecules labeled with N (iodoacetylamino)-1-naphthylamine-5-sulfonic acid (1,5-IAEDANS) and iodoacetamidofluorescein (IAF) support these conclusions.

A hypothesis is presented in which the physiological release of Ca from sarcoplasmic reticulum occurs through hydrophilic channels generated by the reversible formation of ATPase tetramers under the influence of action potential.

Keywords

Sarcoplasmic Reticulum Purple Membrane Frog Skeletal Muscle Sarcoplasmic Reticulum Membrane Fluorescence Energy Transfer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1977

Authors and Affiliations

  • A. Martonosi
  • H. Nakamura
  • R. L. Jilka
  • J. H. Vanderkooi

There are no affiliations available

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