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The “Low-Flow” State Following Total Cerebral Ischemia

  • J. G. Wade
  • W. A. Tweed
  • W. J. Davidson
Conference paper

Summary

Following 16 min of complete cerebral ischemia, produced in rats by occluding aortic outflow from the heart, cerebral perfusion rate (CPR) measured at a constant hydrostatic pressure was 7.5% of control. Epinephrine added to the perfusate increase CPR to 40.5% of control. Studies in vitro with preparations of bovine cerebral arteries disclosed two populations of these vessels: (i) arteries 0.7 to 2 mm in diameter which have no spontaneous mechanical activity and contract in a dose-related manner with potassium, epinephrine and histamine, and (ii) arteries 0.3 to 0.5 mm in diameter which have intense spontaneous activity and relax in a dose-related manner with increasing potassium concentration but which have a dose-related contraction response to epinephrine and histamine.

Keywords

Cerebral Ischemia Bathing Fluid Washout Curve Cerebrovascular Resistance Aortic Outflow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1976

Authors and Affiliations

  • J. G. Wade
    • 1
  • W. A. Tweed
    • 1
  • W. J. Davidson
    • 1
  1. 1.Department of Anesthesia and Pharmacology and TherapeuticsUniversity of ManitobaWinnipegCanada

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