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The Effect of THAM on Acute Intracranial Hypertension. An Experimental and Clinical Study

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Abstract

Brain tissue acidosis due to hypoxia may exist in the case of intracranial hypertension. Increased hydrogen ion concentration produces reduction in the vasoconstrictor tone resulting in an enlarged vascular bed that increases intracranial pressure (ICP), which makes a vicious cycle. DOS and coworkers (2) reported that an adequate maintenance of pH with an alkalizing agent, Trishydroxymethylamino methane (THAM), helped to prevent elevation of ICP in cases of hypercapnia due to apneic oxygenation. In the present study, we investigated the effects of alkalizing agents, mainly THAM, on acute intracranial hypertension in experimental animals and clinical cases.

Keywords

  • Intracranial Hypertension
  • Cerebral Vessel
  • Vasoconstrictor Tone
  • Trishydroxymethylamino Methane
  • Succinyl Choline Chloride

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. DOI, A.: Studies on acid-base balance of the cerebrospinal fluid under acute intracranial hypertension (In Japanese). Okayama Igakkai Zasshi 82, 361–372 (1970).

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  2. DOS, S.J., NAHAS, G.G., PAPPEN, E.M.: Experimental correction of hypercapnic intracranial hypertension. Anesthesiology 23, 46–50 (1962).

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  3. IWATSUKI, K.: Cerebrovascular CO2 reactivity under intracranial hypertension in dogs (In Japanese). Brain Nerve 27, 959–966 (1975).

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  4. LANGFITT, T.W., WEINSTEIN, J.D., KASSEL, N.F.: Cerebral vasomotor paralysis produced by intracranial hypertension. Neurology 15, 622–641 (1965).

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  5. LILLEHEI, R.C., LONGERBEAM, J.K., BLOCH, J.H., MANAX, W.G.: The nature of irreversible shock: Experimental and clinical observations. Ann. Surg. 160, 682–710 (1964).

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© 1976 Springer-Verlag Berlin · Heidelberg

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Akioka, T. et al. (1976). The Effect of THAM on Acute Intracranial Hypertension. An Experimental and Clinical Study. In: Beks, J.W.F., Bosch, D.A., Brock, M. (eds) Intracranial Pressure III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66508-0_37

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  • DOI: https://doi.org/10.1007/978-3-642-66508-0_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66510-3

  • Online ISBN: 978-3-642-66508-0

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