Abstract
It is now well accepted that a high concentration of plasma cholesterol is one of the principal risk factors in the development of coronary, peripheral and cerebral arteriosclerosis in man. Investigations in different animal species have clearly shown that there exists a direct relationship between the accumulation of cholesterol in the tissue of the arterial wall and hypercholesterolemia. By immunochemical techniques beta-lipoproteins or apoproteins could be demonstrated in atheromatous plaques (SMITH and SLATER, 1972; STEIN et al. , 1973). Furthermore, clinical and epidemiological evidence has implicated elevated very low density lipoproteins as an additional risk factor for clinical atherosclerosis (CARLSON and BÖTTIGER, 1972). However, the mechanism by which these macromolecules with a diameter of approximately 300–800 Å penetrate into the arterial wall has not yet been elucidated.
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References
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Greten, H. (1976). Capillary Endothelium — The Possible Site of Action of Different Lipolytic Enzymes. In: Effert, S., Meyer-Erkelenz, J.D. (eds) Blood Vessels. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66471-7_3
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DOI: https://doi.org/10.1007/978-3-642-66471-7_3
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