Abstract
Members of this group have studied the physical chemistry of the blood vascular interface for 25 years (SAWYER and PATE, 1953a). Our initial findings stemmed from the investigations of the healing characteristics of preserved vascular bypass grafts, the freezed dried homograft (SAWYER and PATE, 1953b, c). It was during these experiments that we observed that under normal in vivo conditions, the vascular interface is invariably negatively charged (SAWYER and PATE, 1953b). From these early beginnings developed a series of experiments evaluating the effect of both charge and electric currents on thrombosis of the vascular tree (SAWYER and DEUTSCH, 1956; SAWYER et al. , 1960). The communication which follows will be divided into four sections.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
ABRAMSON, H.W.: “Electrophoresis of Cells and Proteins”. New York: Hafner Publishing Co. 1968.
BAIER, R.E., DEPALMA, V.A., FURUSE, A., GOTT, V.L., KAMMLOTT, G.W., LUCAS, T., SAWYER, P.N., SRINIVASAN, S., STANCZEWSKI, B.: Thromboresistance of glass after glow discharge treatment in organ. J. Biomed. Mater. Res. 9, 547 (1975).
BODDY, P.J., BRATTAIN, W.H., SAWYER, P.N.: Some electrochemical properties of solid-liquid interfaces and the electrode behavior of erythrocytes. “Biophysical Mechanisms in Vascular Homeostasis and Intravascular Thrombosis”. (P.N. Sawyer, ed.). Appleton-Century-Crofts 30 (1965).
CHOPRA, P.S., SRINIVASAN, S., LUCAS, T.R., SAWYER, P.N.: Relation between thrombosis on metal electrodes and the position of metal in the electromotive series. Nature 215, 1494 (1967).
DUIC, L., SRINIVASAN, S., SAWYER, P.N.: Electrochemical behavior of blood coagulation factors - prothrombin and thrombin. J. Electrochem. Soc. 120, 348 (1973).
GILEADI, E., STANCZEWSKI, B., PARMEGGIANI, A., LUCAS, T.R., RANGANATHAN, M., SRINIVASAN, S., SAWYER, P.N.: Antithrombogenic characteristics of cathodically polarized copper prostheses. J. Biomed. Mater. Res. 6, 489 (1972).
HARSHAW, D.H., ZISKIND, H.S., WESOLOWSKI, S.A., SAWYER, P.N.: The ionic structure of the blood intimal interface as an aid in the development of vascular prostheses. Trans. Amer. Soc. Artif. Int. Organs 9, 317 (1963).
LANDIS, E.M., PAPPENHEIMER, J.R.: Exchange of substance through the capillary walls. Handbook of Physiology, Vol. II, page 961. Baltimore, Maryland: Williams and Wilkins 1963.
LEE, M.E., MURAKAMI, T., STANCZEWSKI, B., PARMEGGIANI, A., SRINIVASAN, S., SAWYER, P.N.: Etiology of thrombus formation on prosthetic metal heart valves: the role of spontaneous in vivo interfacial potentials and their measurements. J. Thoracic and Cardiovasc. Surg. 63, 809 (1972).
LUCAS, T.R., BONAVITA, F., RAMASAMY, N., SAWYER, P.N.: The effects of various drugs, membrane poisons and defibrinogenation of platelet adhesion to a metal surface. To be published (1975).
LUCAS, T.R., STANZCEWSKI, B., RAMASAMY, M., SRINIVASAN, S., KAMMLOTT, G.W., SAWYER, P.N.: Nonthrombogenic ac polarized copper prosthesis. Biomat. Med. Dev., Art. Org. 3 (2) 215 (1975).
POORE, G.V.: A text book of electricity in medicine and surgery. London: Smith, Elder and Co. 1876.
RAMASAMY, N., RANGANATHAN, M., DUIC, L., SRINIVASAN, S., SAWYER, P.N.: Electrochemical behavior of blood coagulation factors: Fibrinogen. J. Electrochem. Soc. 170, 354 (1973).
RAMASAMY, N., SRINIVASAN, S., SAWYER, P.N.: Electrochemical behavior of blood coagulation proteins - factors V and VIII. Eletrochem. Acta 19, 137 (1974).
SAWYER, P.N., PATE, J.W.: Intravascular thrombosis of electrical origin. U.S. Armed Forces Med. J. 4, 23 (1953).
SAWYER, P.N., PATE, J.W.: Electrical potential differences across the aorta and aortic graft of dogs. American J. of Physiol. 175, 103 (1953).
SAWYER, P.N., PATE, J.W.: Bio-electric phenomena as an etiology factor in intravascular thrombosis. Am. J. of Physiol. 175, 113 (1953).
SAWYER, P.N., DEUTSCH, B.: Use of electrical currents to delay intravascular thrombosis in experimental animals. Am. J. of Physiol. 187, 473 (1956).
SAWYER, P.N., SUCKLING, E.E., WESOLOWSKI, S.A.: Effect of small electric currents on intravascular thrombosis in the visualized rat mesentery. Am. J. of Physiol. 198, 1006 (1960).
SAWYER, P.N., VALMONT, I.: Evidence of active ion transport across large canine blood vessel walls. Nature 189, 470 (1961).
SAWYER, P.N., LEVINE, J., MAZLEN, R., VALMONT, I.: Active ion transport across canine blooc vessel walls. J. Gen. Physiol. 45, 181 (1961).
SAWYER, P.N., ZISKIND, H., HARSHAW, D.H.: Ion metabolism of the blood vessel wall. Fundamentals of Vascular Grafting. McGraw-Hill, Chap. 1, 3 (1963).
SAWYER, P.N., BURROWES, C.B., OGONIAN, J.C., SMITH, A.O., WESOLOWSKI, S.A.: Ionic architecture at the vascular wall interface. Amer. Soc. Artif. Int. Organs 10, 316 (1964).
SAWYER, P.N., BRATTAIN, W.H., BODDY, P.J.: Electrochemical precipitation of human blood cells and its possible relation to intravascular thrombosis. The National Acad, of Sci. 51, 428 (1964).
SAWYER, P.N., WU, K.T., WESOLOWSKI, S.A., BRATTAIN, W.H., BODDY, P.J.: Electrochemical precipitation of blood cells on metal electrodes; an aid in the selection of vascular prostheses. Nat. Acad. Sci. 53, 294 (1965).
SAWYER, P.N., HIMMELFARB, E., LUSTRIN, I., ZUSKIND, H.: Measurement of streaming potentials of mammalian blood vessels, aorta and vena cava in vivo. Biophys. J. 6 641 (1966).
SAWYER, P.N., HARSHAW, D.H.: Electroosmotic characteristics of canine aorta and vena cava wall. Biophys. J. 6, 653 (1966).
SAWYER, P.N., SRINIVASAN, S.: Studies on the biophysics of intravascular thrombosis. Amer. J. Surg. 113, 42 (1967).
SAWYER, P.N., OGONIAN, J.C., BODDY, P.J.: The interaction between human erythrocytes and metal surfaces. Surg. 61, 448 (1967).
SAWYER, P.N., RAMASAMY, N., STANCZEWSKI, B., STILLMAN, R.M., WREZLEWICZ, W., GOODEMOUGH, S.H.: Implantation studies with titanium aluminum 6-4 ELI tubes. Proceedings of the 28th ACEMB, New Orleans, Sept. 20-24, Extended Abstract, p. 40, 1975.
SAWYER, P.N., STANCZEWSKI, B., RAMASAMY, N., KAMMLOTT, G.W., STEMPAL, J.G., SRINIVASAN, S.: Electrochemical and chemical methods for production of nonthrombogenic metal heart valves; combined biophysical, electron microscopic and scanning electron microscopic studies. Trans. Am. Soc. Artif. Int. Organs 19, 195 (1973).
SCUDAMORE, C.: An Essay on the Blood. Longman, Hurst, Rees, Orme, Brown and Green (1824).
SOLASH, J., PEREZ, R., KEATES, J.S., STEIN, H., TROYANSKI, D., ATEYEN, E., JONES, J.R., SRINIVASAN, S., SAWYER, P.N.: Biophysical studies of effects of hormonal steroids on the vascular system. J. Gyn. Invest. (In press) (1975).
STONER, G.E.: Electrosorption of amin acids, peptides and proteins in relation to the compatibility of materials and the human body. J. Biomed. Mater. Res. 3, 655 (1969).
STONER, G.E., SRINIVASAN, S.: Adsorption of blood proteins on metals using capacitance techniques. J. Phys. Chem. 74, 1088 (1970).
WEISS, L.: Biophysical aspects of initial cell interaction with solid surfaces. Fed. Proc. 30, 1649 (1971).
WESOLOWSKI, S.A., LICHTMAN, H.C., SAWYER, P.N.: Major surgery on the severe hemophiliac, lessons in management. Annals of N.Y. Acad. Sci. 115, 505 (1964).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Sawyer, P.N., Stanczewski, B. (1976). Electrokinetic Processes on Natural and Artificial Blood Vessels. In: Effert, S., Meyer-Erkelenz, J.D. (eds) Blood Vessels. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66471-7_23
Download citation
DOI: https://doi.org/10.1007/978-3-642-66471-7_23
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-07909-5
Online ISBN: 978-3-642-66471-7
eBook Packages: Springer Book Archive