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Autosomal Monosomy and Trisomy Causing Developmental Failure

  • A. Gropp
  • B. Putz
  • U. Zimmermann
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 62)

Abstract

Systematic experimental investigations of the developmental consequences of autosomal monosomy and of trisomy seem to be an interesting task in view of the great clinical importance of chromosomal abnormalities in prenatal pathology of man (Boué et al., 1975; Boué and Boué, 1976). The establishment of preconditions for such studies has been possible by the observation that, in the mouse, structural heterozygosity for one or more metacentric chromosomes may enhance meiotic nondisjunction (Gropp et al., 1970; Tettenborn and Gropp, 1970; Cattanach and Moseley, 1973). Chromosomally hypo- or hypermodal gametes, which are responsible for (whole arm) monosomy or trisomy of the embryo, are produced as a consequence of irregular meiotic segregation.

Keywords

Centric Fusion Metacentric Chromosome Trisomic Cell Autosomal Trisomy Systematic Experimental Investigation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baranov, V.S.: Trisomy in the newborn. Experiments on mice heterozygous for the T6 Bnr translocation. Bull. exp. Biol. Med. 5, 99–103 (1974).Google Scholar
  2. Baranov, V.S., Dyban, A.P.: Embryogenesis and pecularities of karyotype in mouse embryos and centric fusion of chromosomes (Robertsonian translocation). Ontogenese Akad. Nauk SSSR 2, 164–175 (1971).Google Scholar
  3. Boer, P. de: Fertile tertiary trisomy in the mouse (Mus musculus). Cytogenet. Cell Genet. 12, 435–442 (1973).PubMedCrossRefGoogle Scholar
  4. Boer, P. de, Groen, A.: Fertility and meiotic behavior of male T 70 H tertiary trisomies of the mouse (Mus musculus). Cytogenet. Cell Genet. 13, 489–510 (1974).PubMedCrossRefGoogle Scholar
  5. Boué, J.G., Boué, A.: Chromosomal anomalies in early spontaneous abortion. Current Topics in Pathology (ed. A. Gropp). 62, 193–208 (1976).Google Scholar
  6. Boué, J., Boué, A., Lazar, P.: The epidemiology of human spontaneous abortions with chromosomal anomalies. Aging Gametes, Int. Symp., Seattle 1973, pp. 330–348. Basel: Karger 1975.Google Scholar
  7. Capanna, E., Cristaldi, M., Perticone, P., Rizzoni, M.: Identification of chromosomes involved in the nine Robertsonian fusions of the Appenine mouse with a 22-chromosome karyotype. Experientia (Basel) 31, 294–296 (1975).CrossRefGoogle Scholar
  8. Cattanach, B.M., Williams, C.E., Bailey, H.: Identification of the linkage groups carried by the metacentric chromosomes of the tobacco mouse (Mus poschiavinus). Cytogenet. Cell Genet. 11, 412–423 (1972).CrossRefGoogle Scholar
  9. Cattanach, B.M., Moseley, H.: Nondisjunction and reduced fertility caused by the tobacco mouse metacentric chromosomes. Cytogenet. Cell Genet. 12, 264–287 (1973).PubMedCrossRefGoogle Scholar
  10. Citoler, P., Gropp, A., Kolbus, M., Reinhardt, P., Schaefer, R.: Metabolism of the placenta and foetus in the trisomy-syndrome of mice. IV. Konferenz der Europäischen Gesellschaft für Teratologie, Freudenstadt 23.-25. Sept. 1975. Abstract.Google Scholar
  11. Cure, S., Boué, A., Boué, J.: Consequence of chromosomal anomalies on cell multiplication. Symposium “Les accidents chromosomiques de la réproduction” (ed. A. Boué, Ch. Thibault), pp. 95–109. INSERM 1973.Google Scholar
  12. Ford, C.E.: The population cytogenetics of other mammalian species. Pfizer Med. Monogr. 5: Human Population Cytogenetics, pp. 222–239. Edinburgh University Press 1970.Google Scholar
  13. Gropp, A.: Chromosomal animal model of human disease. Fetal trisomy and developmental failure. In: Teratology (ed. L. Berry, D.E. Poswillo), pp. 17–33. Berlin-Heidelberg-New York: Springer 1975.CrossRefGoogle Scholar
  14. Gropp, A., Giers, D., Kolbus, U.: Trisomy in the fetal backcross progeny of male and female metacentric heterozygotes of the mouse. I. Cytogenet. Cell Genet. 13, 511–535 (1974).PubMedCrossRefGoogle Scholar
  15. Gropp, A., Hilwig, I., Seth, P.K.: Fluorescence chromosome banding patterns — produced by a benzimidazole derivative. Proc. 23rd Nobel Symposium. Stockholm, September 25-27, 1972 (ed. T. Caspersson, L. Zech), pp. 300–306. The Nobel Foundation, Stockholm and Academic Press, New York 1973.Google Scholar
  16. Gropp, A., Kolbus, U., Giers, D.: Systematic approach to the study of trisomy in the mouse II. Cytogenet. Cell Genet. 14, 42–62 (1975).PubMedCrossRefGoogle Scholar
  17. Gropp, A., Tettenborn, U., Lehman, E. von: Chromosomenvariation vom Robertson’schen Typus bei der Tabakmaus M. poschiavinus und ihren Hybriden mit der Laboratoriumsmaus. Cytogenet. Cell Genet. 9, 9–23 (1970).CrossRefGoogle Scholar
  18. Gropp, A., Winking, H., Zech, L., Müller, H.J.: Robertsonian chromosomal variation and identification of metacentric chromosomes in feral mice. Chromosoma (Berl.) 39, 265–288 (1972).CrossRefGoogle Scholar
  19. Kalter, H., Warkany, J.: Experimental production of congenital malformations in strains of inbred mice by maternal treatment with hypervitaminosis. A. Amer.J. Path. 38, 1–21 (1961).Google Scholar
  20. Kuliev, A.M., Kukharenko, V.I., Grinberg, K.N.: Morphological autoradiographic, immunochemical and cytochemical investigation of a cell strain with trisomy 7 from a spontaneous abortus. Humangenetik 17, 285–296 (1973).PubMedGoogle Scholar
  21. Langman, J., Welch, G. W.: Effect of vitamin A on the development of the central nervous system. J. comp. Neurol. 128, 1–15 (1966).PubMedCrossRefGoogle Scholar
  22. Léonardt, A., Deknudt, G.H.: A new marker for chromosome studies in the mouse. Nature (Lond.) 214, 504–505 (1967).CrossRefGoogle Scholar
  23. McClure, H.M., Belden, K.H., Pieper, W.A., Jacobson, C.B.: Autosomal trisomy in a chimpanzee: resemblance to Down’s syndrome. Science 165, 1010–1012 (1969).PubMedCrossRefGoogle Scholar
  24. Mori, M., Sasaki, M., Makino, S., Ishikawa, T., Kawata, K.: Autosomal trisomy in a malformed newborn calf. Proc. jap. Acad. 45, 955–959 (1969).Google Scholar
  25. Paton, G.R., Silver, M.F., Allison, A.C,: Comparison of cell cycle time in normal and trisomiccells. Humangenetik 23, 173–182 (1974).PubMedGoogle Scholar
  26. Polani, P.E.: Chromosomal and other genetic influences on birth weight variation. In: Size at Birth, Ciba Found. Symp. 27 (new series), pp. 127–164. North Holland: Elsevier Exc. Medica 1974.Google Scholar
  27. Schneider, E.L., Epstein, Ch.J.: Replication rate and life span of culture fibroblasts in Down’s syndrome (36940). Proc. Soc. exp. Biol. (N.Y.) 141, 1092–1094 (1972).Google Scholar
  28. Tettenborn, U., Gropp, A.: Meiotic nondisjunction in mice and mouse hybrids. Cytogenetics 9, 272–283 (1970).PubMedCrossRefGoogle Scholar
  29. Winking, H., Gropp, A.: Meiotic non-disjunction of metacentric heterozygotes in oocytes versus spermatocytes. Serono Symp. Freiburg, 10.–12. Sept. 1975. New York-London: Academic Press, in press.Google Scholar

Copyright information

© Springer-Verlag Berlin-Heidelberg 1976

Authors and Affiliations

  • A. Gropp
  • B. Putz
  • U. Zimmermann

There are no affiliations available

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