Autosomal Monosomy and Trisomy Causing Developmental Failure

  • A. Gropp
  • B. Putz
  • U. Zimmermann
Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 62)


Systematic experimental investigations of the developmental consequences of autosomal monosomy and of trisomy seem to be an interesting task in view of the great clinical importance of chromosomal abnormalities in prenatal pathology of man (Boué et al., 1975; Boué and Boué, 1976). The establishment of preconditions for such studies has been possible by the observation that, in the mouse, structural heterozygosity for one or more metacentric chromosomes may enhance meiotic nondisjunction (Gropp et al., 1970; Tettenborn and Gropp, 1970; Cattanach and Moseley, 1973). Chromosomally hypo- or hypermodal gametes, which are responsible for (whole arm) monosomy or trisomy of the embryo, are produced as a consequence of irregular meiotic segregation.


Centric Fusion Metacentric Chromosome Trisomic Cell Autosomal Trisomy Systematic Experimental Investigation 
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© Springer-Verlag Berlin-Heidelberg 1976

Authors and Affiliations

  • A. Gropp
  • B. Putz
  • U. Zimmermann

There are no affiliations available

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