Pharmacological Actions

  • B. Mauricio Altura
  • S. Halevy
  • L. R. Johnson
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 18 / 2)

Abstract

During the past eight decades, histamine has, from time to time, been both invoked and challenged as a physiologic regulator of the cardiovascular system (Lewis, 1927; Dale, 1929a, b; Best and McHenry, 1931; Burn, 1950; Schayer, 1968; Altura and Zweifach, 1965 a, b; Rocha e Silva, 1966; Kahlson and Rosengren, 1968, 1971; Altura and Altura, 1974a; Levi et al., 1976; Powell and Brody, 1976). Although certain aspects of the actions of histamine on some parts of the cardiovascular system have been reviewed previously (Rocha e Silva, 1966; Beck, 1965; Somlyo and Somlyo, 1970; Altura, 1971, 1976, 1977; Altura and Altura, 1974a; Shepherd and VanHoutte, 1975, 1977), none of these has analyzed the complex, multifaceted effects this biogenic amine exerts on the systemic, cardiac and regional vasculatures, including those on the microcirculation and vascular smooth muscle. Moreover, species differences among mammals with respect to some of these actions have not been critically evaluated in the past.

Keywords

Nicotinate Morphine Cocaine Prostaglandin Catecholamine 

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© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • B. Mauricio Altura
  • S. Halevy
  • L. R. Johnson

There are no affiliations available

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