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The Effect of Bencyclane on the K+- and Ca++-Induced Pial Arterial Constriction

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Ionic Actions on Vascular Smooth Muscle

Abstract

By using the technique of perivascular microperfusion (14), we studied which effect varied K+ and Ca++ concentrations in mock CSF with and without Bencyclane take on pial arteries. We used 21 anaesthetized cats for our experiments. We observed that constrictions of pial arteries that are induced by high K+ (3, 12, 18), Ca++ (9, 10, 18), and by mock CSF free of K+ (11, 14) can be inhibited by an additional application of Bencyclane.

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References

  1. AMES, A., SAKANONE, M., ENDO, S.: Electrolytes in CSF. J. Neurophysiol. 27, 672–681 (1964).

    PubMed  Google Scholar 

  2. BRANDT, H., SCHANZENBäCHER, P., ENZENROSS, H.G., BETZ, E.: Die Auswirkung erhöhter Kalziumkonzentrationen im künstlichen Liquor cerebrospinalis auf die Piagefäßweite bei perivasculärer Mikroperfusion und die Hemmwirkung durch Bencyclan. Arzneimittel-Forsch. 25, 1393–1396 (1975).

    CAS  Google Scholar 

  3. BRECHT, K., ESTADA, I.A., GöTZ, A.: Zur Beeinflussung der Gefäßmotorik durch K+ und Ca++ Ionen. Pflügers Arch. ges. Physiol. 279, 330–340 (1964).

    Article  CAS  Google Scholar 

  4. BRIGGS, A.H.: Calcium movements during potassium contracture in isolated aortic strips. Amer. J. Physiol. 203, 849–852 (1962).

    PubMed  CAS  Google Scholar 

  5. FLECKENSTEIN, A., SCHWOERER, W., JANKE, J.: Parallele Beeinflussung der mechanischen Spannungsentwicklung und Spaltung von energiereichem Phosphat bei der Kaliumkontraktur des Froschrectus in Lösungen mit variiertem K+ und Ca++ Gehalt. Pflügers Arch. ges. Physiol. 273, 483–498 (1961).

    Article  CAS  Google Scholar 

  6. FLECKENSTEIN, A., GRüN, G., TRITTHARD, H., BYON, Y.K., HARDING, P.: Uterus-Relaxation durch hochaktive Ca++ antagonistische Hemmstoffe der elektromechanischen Kopplung wie Isoptin (Verapamil, Iproveratril), Substance D 600 und Segontin (Prenylamin). Klin. Wschr. 49, 32–41 (1971).

    Article  PubMed  CAS  Google Scholar 

  7. GäRTNER, E., ENZENROSS, H.G., VLAHOV, V., SCHANZENBäCHER, P., BRANDT, H., BETZ, E.: Durchblutung, Sauerstoffdruck und pH des cerebralen Cortex unter Einwirkung von Bencyclan. Arzneimittel-Forsch. 25, 887–891 (1975).

    Google Scholar 

  8. GRüN, G.: Habilitationsschrift Freiburg 1972.

    Google Scholar 

  9. HINKE, J.A.M., WILSON, M.L., BURNHAM, S.C.: Calcium and the contractility of arterial smooth muscle. Amer. J. Physiol. 206, 211–217 (1964).

    PubMed  CAS  Google Scholar 

  10. HIRAOKA, M., YAMYGISHI, S., SANO, T.: Role of calcium ions in the contraction of vascular smooth muscle. Amer. J. Physiol. 214, 1084–1089 (1968).

    PubMed  CAS  Google Scholar 

  11. KNABE, U., BETZ, E.: The effect of varying extracellular K+, Mg++, and Ca++ on the diameter of pial arterioles. In: Vascular Smooth Muscle. Betz, E. (Ed.) Berlin-Heidelberg-New York: Springer 1972, pp. 83–85.

    Google Scholar 

  12. KONOLD, P., GEBERT, G., BRECHT, K.: The effect of potassium on the tone of isolated arteries. Pflügers Arch. ges. Physiol. 301, 285–291 (1968).

    Article  CAS  Google Scholar 

  13. KURIYAMA, H.: The influence of potassium, sodium and chloride on the potential of the smooth muscle of taenia coli. J. Physiol. (Lond.) 166, 15–28 (1963).

    CAS  Google Scholar 

  14. KUSCHINSKY, W., WAHL, M., BOSSE, G., THURAU, W.: Perivascular potassium and pH as determinants of local pial arterial diameter in cats. Circulat. Res. 31, 240–247 (1970).

    Google Scholar 

  15. SCHäDLER, M.: Proportionale Aktivierung von ATPase-Aktivität und Kontraktionsspannung durch Calciumionen in isolierten kontraktilen Strukturen verschiedener Muskelarten. Pflügers Arch. ges. Physiol. 296, 70–90 (1967).

    Article  Google Scholar 

  16. VAN BREEMEN, C., FARINAS, B.R., GRBA, P.O., MCNAUGHTON, E.P.: Excitation-contraction coupling in rabbit aorta. Studied by the Lanthanum method for measuring cellular calcium influx. Circulat. Res. 30, 44–54 (1972).

    PubMed  Google Scholar 

  17. VLAHOV, V., ENZENROSS, H.G., BRANDT, H., BETZ, E.: The effect of K+ on the contraction of pial arteries. Pflügers Arch. 343, Suppl. R 24 (1973).

    Google Scholar 

  18. WAUGH, W.H.: Role of calcium in the contractile excitation of vascular smooth muscle by epinephrine and potassium. Circulat. Res. 11, 927–940 (1962).

    PubMed  CAS  Google Scholar 

  19. Fleckenstein, A.: Interactions of H+ ions, Ca++-antagonistic drugs and cardiac glycosides with excitation-contraction coupling of vascular smooth muscle. See this book.

    Google Scholar 

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Authors
  1. P. Schanzenbächer
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Editors and Affiliations

  1. Physiologisches Institut, Lehrstuhl I, Gmelinstr. 5, 7400, Tübingen, Germany

    Eberhard Betz

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© 1976 Springer-Verlag Berlin Heidelberg

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Schanzenbächer, P. (1976). The Effect of Bencyclane on the K+- and Ca++-Induced Pial Arterial Constriction. In: Betz, E. (eds) Ionic Actions on Vascular Smooth Muscle. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66427-4_26

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  • DOI: https://doi.org/10.1007/978-3-642-66427-4_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-07836-4

  • Online ISBN: 978-3-642-66427-4

  • eBook Packages: Springer Book Archive

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