Cardiac Pacing pp 132-141 | Cite as

Drug Effects on AV Conduction

  • H. Neuss
  • H.-J. Schaumann
  • B. Stegaru
Conference paper


In recent years His bundle electrography has proved to be a valuable method for analysis of conduction disorders. In addition, drug effects on AV conduction and the preferential site of drug action can be evaluated with this method. Its accuracy, however, is limited. Pharmacologically induced changes of the conduction intervals must exceed at least 5 or 10 ms for reliable measurement at a recording paper speed of 100 mm/s (0.5–1 mm). Therefore, 10 or even 20% changes of the P — A and H — R intervals (normal values about 30 and 40 ms, respectively) may excape recognition.


Refractory Period Right Bundle Branch Block Intraventricular Conduction Basic Heart Rate Atrial Electrogram 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Akhtar, M., Damato, A. N., Caracta, A. R., Batsford, W. P., Josephson, M. E., Lau, S. H.: Electrophysiologic effects of atropine on atrioventricular conduction studied by His bundle electrogram. Amer. J. Cardiol. 33, 333–343 (1974)PubMedCrossRefGoogle Scholar
  2. 2.
    Beck, O. A., Witt, E., Hochrein, H.: Der Einfluß des Antiarrhythmikums Propafenon auf die intrakardiale Erregungsleitung. Klinische Untersuchungen mit Hilfe der His-Bündel-Elektrographie. Z. Kardiol. 64, 179–187 (1975)PubMedGoogle Scholar
  3. 3.
    Befeler, B., Castellanos Jr., A., Wells, D. E., Celeste Vagueiro, M., Yeh, B. K.: Electrophysiologic effects of the antiarrhythmic agent disopyramide phosphate. Amer. J. Cardiol. 35, 282–287 (1975)PubMedCrossRefGoogle Scholar
  4. 4.
    Bekheit, S., Murtagh, J. G., Morton, P., Fletcher, E.: Effect of lignocaine on conducting system of human heart. Brit. Heart J. 35, 305–311 (1973)PubMedCrossRefGoogle Scholar
  5. 5.
    Berkowitz, W. D., Wit, A. L., Lau, S. H., Steiner, Gh., Damato, A. N.: The effects of propranolol on cardiac conduction. Circulation 40, 855–862 (1969)Google Scholar
  6. 6.
    Bisset, J. K., De Soyza, N. D. B., Kane, J. J., Murphy, M. L.: Improved intraventricular conduction of premature beats after diphenylhydantoin. Amer. J. Cardiol. 33, 493–497 (1974)CrossRefGoogle Scholar
  7. 7.
    Damato, A. N., Berkowitz, W. D., Patton, R. D., Lau, S. H.: The effect of diphenylhydantoin on atrioventricular and intraventricular conduction in man. Amer. Heart J. 79, 51–56 (1970)PubMedCrossRefGoogle Scholar
  8. 8.
    Denes, P., Wu, D., Dhingra, R., Pietras, R. J., Rosen, K. M.: The effects of cycle length on cardiac refractory periods in man. Circulation 49, 32–41 (1974)PubMedGoogle Scholar
  9. 9.
    Dhingra, R. G, Winslow, E., Pouget, J. M., Rahimtoola, S. H., Rosen, K. M.: The effect of isoproterenol on atrioventricular and intraventricular conduction. Amer. J. Cardiol. 32, 629–636 (1973)PubMedCrossRefGoogle Scholar
  10. 10.
    Gleichmann, U., Seipel, J., Loogen, F.: Der Einfluß von Antiarrhythmika auf die intrakardiale Erregungsleitung (His-Bündel-Elektrographie) und Sinusknotenautomatie beim Menschen. Dtsch. med. Wschr. 98, 1487–1994 (1973)PubMedCrossRefGoogle Scholar
  11. 11.
    Guérot, C., Coste, A., Valere, P. E., Tricot, R.: L’épreuve à l’Ajmahne dans le diagnostic du bloc auriculoventriculaire paroxystique. Arch. Mal. Coeur 66, 1241–1253 (1973)PubMedGoogle Scholar
  12. 12.
    Gupta, P. K., Lichstein, E., Chadda, K. D: Lidocaine-Induced heart block in patients with bundle branch block. Amer. J. Cardiol. 33, 487–492 (1974)PubMedCrossRefGoogle Scholar
  13. 13.
    Husaini, M. H., Kvasnicka, J., Rydén, L., Holmberg, S.: Action of verapamil on sinus node, atrioventricular, and intraventricular conduction. Brit. Heart J. 35, 734–737 (1973)PubMedCrossRefGoogle Scholar
  14. 14.
    Josephson, M. E., Caracta, A. R., Lau, S. H., Gallagher, J. J., Damato, A. N.: Effects of lidocaine on refractory periods in man. Amer. Heart J. 84, 778–786 (1972)PubMedCrossRefGoogle Scholar
  15. 15.
    Josephson, M. E., Seides, S. F., Batsford, W. P., Weisfogel, G. M., Akhtar, M., Caracta, A. R., Lau, S. H., Damato, A. N.: The electrophysiological effects of intramuscular quinidine on the atrioventricular conducting system in man. Amer. Heart J. 87, 55–64 (1974)PubMedCrossRefGoogle Scholar
  16. 16.
    Josephson, M. E., Caracta, A. R., Ricciutti, M. A., Lau, S. H., Damato, A. N.: Electrophysiologic properties of procainamide in man. Amer. J. Cardiol. 33, 596–603 (1974)PubMedCrossRefGoogle Scholar
  17. 17.
    Kulbertus, H., Collignon, P.: Action des antiarythmiques sur la conduction intracardiaque. Acta cardiol. (Brux.) Suppl. 18, 241–250 (1974)PubMedGoogle Scholar
  18. 18.
    Lichstein, E., Chadda, K. D., Gupta, P. K.: Atrioventricular Block with Lidocaine therapy. Amer. J. Cardiol. 31, 277–281 (1973)PubMedCrossRefGoogle Scholar
  19. 19.
    Neuss, H., Schlepper, M.: Der Einfluß von Verapamil auf die atrio-ventrikuläre Überleitung. Lokaüsation des Wirkungsortes mit His-Bündel-Elektrogrammen. Verh. dtsch. Ges. Kreisl.-Forsch. 37, 433–438 (1971)Google Scholar
  20. 20.
    Neuss, H., Schlepper, M.: Die Aussagefähigkeit verschiedener Stimulationsverfahren bei Untersuchungen über die AV-Überleitung — dargestellt an der Einwirkung von Ajmalin. Verh. dtsch. Ges. Kreisl.-Forsch. 39, 222–227 (1973)Google Scholar
  21. 21.
    Neuss, H., Schlepper, M.: Influence of various antiarrhythmic drugs (aprindine, ajmaline, verapamil, Oxprenolol, orciprenaline) on functional properties of accessory A — V pathways. Acta cardiol. (Brux.) Suppl. 18, 279–288 (1974)PubMedGoogle Scholar
  22. 22.
    Neuss, H., Schlepper, M.: Propafenone in patients with paroxysmal supraventricular tachycardias. In preparationGoogle Scholar
  23. 23.
    Neuss, H., Schlepper, M., Thormann, J.: Khnisch-experimentelle Befunde bei frequenzabhängigem Linksschenkelblock. Verh. dtsch. Ges. Kreisl.-Forsch. 40, 402–405 (1974)Google Scholar
  24. 24.
    Neuss, H., Nowak, F. G., Schlepper, M., Wüsten, B.: The effects of anti-anginal drugs on AV-conduction in normal subjects. Arzneimittel-Forsch. (Drug Res.) 24, 213–216 (1974)Google Scholar
  25. 25.
    Neuss, H., Schulze, V., Schlepper, M.: Beeinflussung der Leitungseigenschaften akzessorischer AV-Verbindungen durch Aprindin. Herz/Kreisl. 6, 476–484 (1974)Google Scholar
  26. 26.
    Neuss, H., Spies, H. F., Schlepper, M.: Beeinflussung der Refraktärzeiten in den einzelnen Abschnitten des Reizleitungssystems durch Antiarrhythmika. In: Symposion über His-Bündel-Elektrographie. Stuttgart: Schattauer Verlag, 1975, p. 207Google Scholar
  27. 27.
    Neuss, H., Thormann, J.: Unpublished dataGoogle Scholar
  28. 28.
    Przybyla, A. C., Paulay, K. L., Stein, E., Damato, A. N.: Effects of Digoxin on Atrioventricular conduction patterns in man. Amer. J. Cardiol. 33, 344–350 (1974)PubMedCrossRefGoogle Scholar
  29. 29.
    Rosen, K. M., Lau, S. H., Weiss, M. B., Damato, A. N.: The effect of lidocaine on atrioventricular and intraventricular conduction in man. Amer. J. Cardiol. 25, 1–5 (1970)PubMedCrossRefGoogle Scholar
  30. 30.
    Rosen, K. M., Barwolf, Ch., Ehsani, A., Rahimtoola, S. H.: Effects of lidocaine and propranolol on the normal and abnomalous pathways in patients with preexcitation. Amer. J. Cardiol. 30, 801–809 (1972)PubMedCrossRefGoogle Scholar
  31. 31.
    Rosenbaum, M. B.: A new clinical and experimental model for studying the effects of antiarrhythmic drugs upon automaticity and conduction. Acta cardiol. (Brux.) Suppl. 18, 289–296 (1974)PubMedGoogle Scholar
  32. 32.
    Rosenbaum, M. B., Chiale, P. A., Ryba, D., Elizari, M. V.: Control of tachyarrhythmias associated with Wolff-Parkinson-White syndrome by amiodarone hydrochloride. Amer. J. Cardiol. 34, 215–223 (1974)PubMedCrossRefGoogle Scholar
  33. 33.
    Scheinman, M. M., Weiss, A. N., Shafton, E., Benowitz, N., Rowland, M.: Electrophysiologic effects of procaine amide in patients with intraventricular conduction delay. Circulation 49, 522–529 (1974)PubMedGoogle Scholar
  34. 34.
    Schlepper, M., Neuss, H.: Changes of refractory periods in the A-V conduction system induced by antiarrhythmic drugs. A study using His bundle recordings. Acta cardiol. (Brux.) Suppl. 18, 269–277 (1974)PubMedGoogle Scholar
  35. 35.
    Seipel, L., Gleichmann, U.: Die Wirkung des Antiarrhythmikums Aprindin (AC 1802) auf Erregungsleitung und Spontanautomatie des menschlichen Herzens. Z. Kardiol. 63, 426–434 (1974)PubMedGoogle Scholar
  36. 36.
    Seipel, L., Breithardt, G., Both, A.: Elektrophysiologische Effekte der Antiarrhythmika Disopyramid und Propafenon auf das menschliche Reizleitungssystem. Z. Kardiol 64, 731–740 (1975)PubMedGoogle Scholar
  37. 37.
    Singh, B. N., Hauswirth, O.: Comparative mechanisms of action of antiarrhythmic drugs. Amer. Heart J. 87, 367–382 (1974)PubMedCrossRefGoogle Scholar
  38. 38.
    Smithen, Ch. S., Balcon, R., Sowton, E.: Use of bundle of His potentials to assess changes in atrioventricular conduction produced by a series of beta-adrenergic blocking agents. Brit. Heart J. 33, 955–961 (1971)PubMedCrossRefGoogle Scholar
  39. 39.
    Spies, H. F., Neuss, H.: Funktionsdiagnostik der AV-Überleitung bei Schenkelblock. Herz/Kreisl. 7, 34–41 (1975)Google Scholar
  40. 40.
    Spurrell, R. A. J., Krikler, D. M., Sowton, E.: Concealed Bypasses of the atrioventricular node in patients with paroxysmal supraventricular tachycardia revealed by intracardiac electrical stimulation and verapamil. Amer. J. Cardiol. 33, 590–595 (1974)PubMedCrossRefGoogle Scholar
  41. 41.
    Spurrell, R. A. J., Krikler, D. M., Sowton, E.: Effects of verapamil on electrophysiological properties of anomalous atrioventricular connexion in Wolff-Parkinson-White syndrome. Brit. Heart J. 36, 256–264 (1974)PubMedCrossRefGoogle Scholar
  42. 42.
    Thormann, J., Schwarz, F., Zimmermann, H.: Effects of practolol on A-V conduction during atrial stimulation in 50 patients with and without coronary heart disease. Basic Res. Cardiol. 70, 299–306 (1975)PubMedCrossRefGoogle Scholar
  43. 43.
    Wellens, H. J., Durrer, D.: Effect of digitalis on atrioventricular conduction and circus-movement tachycardias in patients with Wolff-Parkinson-White syndrome. Circulation 47, 1229–1233 (1973)PubMedGoogle Scholar
  44. 44.
    Wellens, H. J., Durrer, D.: Effect of procaine amide, quinidine, and ajmaline in the Wolff-Parkinson-White syndrome. Circulation 50, 114–120 (1974)PubMedGoogle Scholar
  45. 45.
    Wellens, H. J.: Effect of drugs in the Wolff-Parkinson-White syndrome. In: Recent Advances in Ventricular Conduction, Cerqueira-Gomes, M. (ed.) Basel: Karger, 1975, Vol. XIV, pp. 230–240Google Scholar
  46. 46.
    Wit, A. L., Weiss, M. B., Berkowitz, W. D., Rosen, K. M., Steiner, Ch., Damato, A. N.: Patterns of atrioventricular conduction in the human heart. Circulat. Res. 27, 345–352 (1970)PubMedGoogle Scholar
  47. 47.
    Wit, A. L., Hoffman, B. F., Cranefield, P. F.: Slow Conduction and reentry in the ventricular conducting system. Circulat. Res. 30, 1–10 (1972)PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1976

Authors and Affiliations

  • H. Neuss
  • H.-J. Schaumann
  • B. Stegaru

There are no affiliations available

Personalised recommendations