Anabolic-Androgenic Steroids and Experimental Mammary Tumors

Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 43)


Androgens have been used with success for the treatment of advanced disease states in patients with breast cancer. In a large collaborative study, conducted by the Cooperative Breast Cancer Group (1964), an overall remission rate of 21% was found. The criteria used for defining a remission were quite strict. Another finding from this study was that efficacy was related to menopausal status of the patient, with the highest remission rates found in women who were at least 5 years postmenopausal. This cooperative group clearly established that remission was correlated with prolongation of survival, since the responders to androgen therapy survived on the average twice as long as the patients who failed to respond. The androgens employed in these studies were either testosterone propionate or fluoxymesterone, both potent androgens that produce obvious masculinization (Segaloff et al., 1951). Active programs were initiated to devise compounds having equal or better antitumor effects, but with less androgenic “side-effects.” 1


Leukemia Propionate Adenoma Progesterone Prolactin 


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© Springer-Verlag Berlin · Heidelberg 1976

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  • R. Hilf

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