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The Metabolism in Vitro of Anabolic-Androgenic Steroids by Mammalian Tissues

  • Chapter
Anabolic-Androgenic Steroids

Abstract

Very early in the development of our knowledge of the biochemistry of the internal secretion of the testis it was recognized that the product of the testis was metabolized during its circulation through the body. The active principle isolated from the urine—androsterone—was chemically and biologically different from the active principle of the testis—testosterone. Furthermore, the injection of potent urinary extracts and later pure testosterone and related compounds resulted in the isolation of only a fraction of the biological activity from the urine due primarily to the conversion to less active metabolites, e.g., 5α-androsterone and 5β-androsterone. This conversion initially suggested a detoxifying process. Since the liver is assumed to be the main organ for the maintenance of homeostasis, the ability of this organ to metabolize these steroids was studied. Subsequent studies, however, have indicated that not only do many other tissues metabolize these steroids but also that the products formed are different and the spectrum of products varies with animal species suggesting specific metabolic roles for the various metabolites in accordance with tissue and animal species.

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  1. C. D. Kochakian
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  2. N. Arimasa
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  1. Experimental Endocrinology, The University of Alabama in Birmingham, Medical Center, 1919 Seventh Avenue South, Birmingham, AL, 35294, USA

    Charles D. Kochakian Ph.D. (Director and Professor) (Director and Professor)

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Kochakian, C.D., Arimasa, N. (1976). The Metabolism in Vitro of Anabolic-Androgenic Steroids by Mammalian Tissues. In: Kochakian, C.D. (eds) Anabolic-Androgenic Steroids. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66353-6_10

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