The Functional State of the Uninvolved Heart Muscle Following Experimental Myocardial Infarction

  • P. Mathes
Conference paper
Part of the International Boehringer Mannheim Symposia book series (BOEHRINGER)

Abstract

Acute myocardial infarction is regularly followed by a depression in ventricular function (6–9). The performance of the ventricle will depend largely on the extent of myocardial necrosis; however, the function of the surviving heart muscle, which has to compensate for the loss of viable myocardium, has to be considered as well. Determinations of ventricular function following infarction fail to differentiate between the infarcted and the surviving segment. Following experimental infarction, the clearly nonischemic portion of the heart muscle shows changes in its energy metabolism as well as a reversible decline in norepinephrine content (1–3). The functional significance of these changes, however, remains largely unknown. In the present study, analysis of myocardial function was carried out after isolation of the surviving heart muscle, to exclude any effect of the infarct itself. To avoid the illdefined changes in the border zone of the infarct, right ventricular papillary muscles were analyzed following left ventricular infarction. An attempt was thus made to determine the effect of an acute myocardial infarction on the contractile properties of the surviving, noninfarcted heart muscle.

Keywords

Depression Prolin Norepinephrine Catecholamine Cardiol 

Der Funktionszustand des nicht infarktbezogenen Herzmuskels nach experimentellem Herzinfarkt

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References

  1. 1.
    Gudbjarnason, S., Puri, P.S., Mathes, P.: Biochemical changes in non-infarcted heart muscle following myocardial infarction. J. Mol. Cell. Cardiol. 2, 253–273 (1971)PubMedCrossRefGoogle Scholar
  2. 2.
    Mathes, P., Gudbjarnason, S.: Changes in norepinephrine stores in the canine heart following experimental myocardial infarction. Amer. Heart J. 81, 211–217 (1971 a)PubMedCrossRefGoogle Scholar
  3. 3.
    Mathes, P., Cowan, C., Gudbjarnason, S.: Storage and metabolism of norepinephrine after experimental myocardial infarction. Amer. J. Physiol. 220, 27–31 (1971 b)PubMedGoogle Scholar
  4. 4.
    Theroux, P., Franklin, D., Ross, J.Jr., Kemper, W.S.: Regional myocardial function during acute coronary occlusion and its modification by pharmacologic agents in the dog. Circulat. Res. 35, 896–908 (1974)PubMedGoogle Scholar
  5. 5.
    Bowditsch, H.P.: Über die Eigentümlichkeiten der Reizbarkeit, welche die Muskelfasern des Herzens zeigen. Arb. Physiol. Anstalt Leipzig 6, 139 (1871)Google Scholar
  6. 6.
    Rahimtoola, S.H., di Gilio, M.M., Ehsani, A., Loeb, H.S., Rosen, K.M., Gunnar, R.M.: Changes in left ventricular performance from early after acute myocardial infarction to the convalescent phase. Circulation 46, 770–779 (1972)PubMedGoogle Scholar
  7. 7.
    Broder, M.I., Cohn, J.N.: Evolution of abnormalities of left ventricular function after acute myocardial infarction. Circulation 46, 731–743 (1972)PubMedGoogle Scholar
  8. 8.
    Bleifeld, W., Hanrath, P., Merx, W., Heinrich, K.W., Effert, S.: Akuter Myokardinfarkt I. Hämodynamik des linken Ventrikels Dtsch. med. Wschr. 97, 1807–1815 (1972)CrossRefGoogle Scholar
  9. 9.
    Kumar, R., Hood, W.B., Joison, J., Norman, J.C., Abelman, W.H.: Experimental myocardial infarction H. Acute depression and subsequent recovery of left ventricular function: Serial measurements in intact conscious dogs. J. Clin. Invest. 49, 55–62 (1970)PubMedCrossRefGoogle Scholar
  10. 10.
    Hood, W.B.: Experimental myocardial infarction. DDL Recovery of left ventricular function in the healing phase. Contribution of increased fiber shortening in noninfarcted myocardium. Amer. Heart J. 79, 531–538 (1970)PubMedCrossRefGoogle Scholar
  11. 11.
    Richardson, J.A.: Circulating levels of catecholamines in acute myocardial infarction and angina pectoris. Progr. Cardiovasc. Dis. 6, 56–73 (1963)CrossRefGoogle Scholar
  12. 12.
    Spann, J.F., Buccino, R.A., Sonnenblick, E.H., Braunwald, W.: Contractile state of cardiac muscle obtained from cats with experimentally produced ventricular hypertrophy and heart failure. Circulat. Res. 21, 341–354 (1967)PubMedGoogle Scholar
  13. 13.
    Bing, O.H.L., Matsushita, S., Fanburg, B.L., Levine, H.J.: Mechanical properties of rat cardiac muscle during experimental hypertrophy. Circulat. Res. 28, 234–245 (1971)PubMedGoogle Scholar
  14. 14.
    Spann, J.F., Sonnenblick, E.H., Cooper, T.: Cardiac norepinephrine stores and the contractile state of heart muscle. Circulat. Res. 19, 317–324 (1966)PubMedGoogle Scholar
  15. 15.
    Dhalla, N.S., Naidu, K.J.R., Bhagat, B.: Biochemical basis of heart function. 1. Relation of catecholamine stores and contractile force in an isolated rat heart. Cardiovasc. Res. 5, 376–382 (1971)PubMedCrossRefGoogle Scholar
  16. 16.
    Blinks, J.R.: Field stimulation as a means of effecting the graded release of autonomic transmitters in isolated heart muscle. J. Pharmacol. exp. Ther. 151, 221–235 (1966)PubMedGoogle Scholar
  17. 17.
    Yoshida, S.: Experimental studies of coronary insufficiency. I. Changes in myocardial contractility in the ischemic area of the ventricle following acute coronary occlusion. Jap. Circulat. J. 33, 1253–1258 (1969)CrossRefGoogle Scholar
  18. 18.
    Heikkilä, J., Tabakin, B.S., Hugenholtz, P.G.: Quantification of function in normal and infarcted regions of the left ventricle. Cardiovasc. Res. 6, 516–531 (1972)PubMedCrossRefGoogle Scholar
  19. 19.
    Swan, H.J.C., Forrester, J.S., Diamond, G.: The hemodynamic basis of shock and acute myocardial infarction: a conceptual model. Circulation 45, 1097–1110 (1972)PubMedGoogle Scholar
  20. 20.
    Parmley, W.W., Chuck, L. Kivowitz, Ch., Mathloff, J.M., Swan, H.J.C.: In vitro length tension relations of human ventricular aneurysms. Amer. J. Cardiol. 32, 889–894 (1973)PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin · Heidelberg 1976

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  • P. Mathes

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