The Functional State of the Uninvolved Heart Muscle Following Experimental Myocardial Infarction
Acute myocardial infarction is regularly followed by a depression in ventricular function (6–9). The performance of the ventricle will depend largely on the extent of myocardial necrosis; however, the function of the surviving heart muscle, which has to compensate for the loss of viable myocardium, has to be considered as well. Determinations of ventricular function following infarction fail to differentiate between the infarcted and the surviving segment. Following experimental infarction, the clearly nonischemic portion of the heart muscle shows changes in its energy metabolism as well as a reversible decline in norepinephrine content (1–3). The functional significance of these changes, however, remains largely unknown. In the present study, analysis of myocardial function was carried out after isolation of the surviving heart muscle, to exclude any effect of the infarct itself. To avoid the illdefined changes in the border zone of the infarct, right ventricular papillary muscles were analyzed following left ventricular infarction. An attempt was thus made to determine the effect of an acute myocardial infarction on the contractile properties of the surviving, noninfarcted heart muscle.
KeywordsAcute Myocardial Infarction Heart Muscle Contractile State Experimental Myocardial Infarction Acute Coronary Occlusion
Der Funktionszustand des nicht infarktbezogenen Herzmuskels nach experimentellem Herzinfarkt
Unable to display preview. Download preview PDF.
- 5.Bowditsch, H.P.: Über die Eigentümlichkeiten der Reizbarkeit, welche die Muskelfasern des Herzens zeigen. Arb. Physiol. Anstalt Leipzig 6, 139 (1871)Google Scholar