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Adenovirus Transcription

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Book cover Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung

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Abstract

Adenoviruses have been isolated from diverse mammalian species, including man and some birds, and some 80 serotypes have now been described (see Norrby, 1971, for a review). Viruses of this group were originally isolated from the respiratory tracts of their hosts, hence their name (Rowe et al., 1953; Enders et al., 1956) and, in man at least, are associated with mild disease of these organs. The 33 known human serotypes of adenovirus have been classified on the basis of their hemagglutinating activity (Rosen, 1960) and their ability to induce tumors in newborn rodents (Huebner, 1967; MacAllister et al., 1969). Either scheme defines four subgroups, but there is little correlation between hemagglutination subgroups I–IV and subgroups A-D defined by oncogenicity in vivo. On the other hand, the allocation of human adenoviruses to oncogenic groups A-D correlates well with the G+C content of their DNA genomes (Green, 1970), DNA:DNA and DNA:RNA homology studies (Lacy and Green, 1964, 1965, 1967) and the results of heteroduplex mapping (Garon et al., 1973).

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    S. J. Flint

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Sharp, P.A., Flint, S.J. (1976). Adenovirus Transcription. In: Arber, W., et al. Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung. Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66336-9_5

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