Genetic Heterogeneities within Idiopathic Diabetes
One of the main purposes in studying the genetics of diabetes mellitus is to determine heterogeneities. Many special types of diabetes, with various types of etiology and pathogenesis and sometimes distinct clinical pictures, have been described. After separation of these special types all remaining diabetics are summarized as idiopathic diabetics. There is conclusive evidence that heredity plays a major role in the eiology in this group of idiopathic diabetics. It is very unlikely that it represents a homogeneous disease. Most probably it consists of various types of diseases with different etiologies, both exogenous and genetic, and even the genetic diabetes is most probably heterogenous. As long as we are not able to subdivide the idiopathic diabetes according to etiology, pathogenesis, or clinical type, we have to confine ourselves to genetic differences between groups of patients which may be classified according to sex, age at onset, weight, or other measurable parameters.
KeywordsJuvenile Diabetes Diabetic Child Juvenile Diabetic Multifactorial Inheritance Homogeneous Disease
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- 1.Carter, C.D.: The inheritance of common congenital malformations. In: Progress in Medical Genetics, Steinberg, A.G. Beam, A.G. New York, London: Grune and Stratton, 1965, Vol. IVGoogle Scholar
- 3.Falconer, D.S.: The inheritance of liability to diseases with variable age of onset, with particular reference to diabetes mellitus. Ann. Hum. Genet. (Lond.) 31, 1–20 (1967)Google Scholar
- 5.General practitioners: The family history of diabetes. Report of a working party appointed by the college of general practitioners. Brit. Med. J. 1 (1960/1965)Google Scholar
- 12.Middleton, G.D., Caird, F. I.: Parity and diabetes mellitus. Brit. J. Prev. Soc. Med. 22, 100 (1968)Google Scholar
- 14.Penrose, L. S.: The genetical background of common diseases. Acta Genet. (Basel) 4, 257 (1953)Google Scholar
- 16.Pyke, D.A.: The incidence of diabetes and its preponderance among-women. Acta Genet. (Basel) 7, 91 (1957)Google Scholar
- 21.Smith, C., Falconer, D. S., Duncan, L. J. P.: A statistical and genetical study of diabetes. Ann. Hum. Genet. (Lond.) 35, 282 (1972)Google Scholar