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Genetic Syndromes Associated with Glucose Intolerance

  • Chapter
The Genetics of Diabetes Mellitus

Abstract

The association of glucose intolerance with a number of distinct genetic syndromes due to mutations at different loci adds great support to the hypothesis that diabetes mellitus represents a heterogeneous group of disorders (66,69). Although these syndromes comprise only a small minority of the cases of diabetes mellitus, they illustrate the wide variety of pathogenetic mechanisms that can resulting lucose intolerance. It must be stressed that the majority of these syndromes simply result in an abnormal glucose tolerance test without any of the clinical features of diabetes mellitus, but this is also true of a large percentage of the cases of so-called idiopathic diabetes mellitus. Thus, in defining the abnormality of carbohydrate metabolism in the various types of glucose intolerance, the presence or absence of clinical symptomatology and specific complications must be delineated, rather than lumping all types of glucose in tolerance under the heading of diabetes mellitus. In this discussion, the term “diabetes” will be used only when the clinical syndrome, rather than uncomplicated glucose intolerance, is present. The more than 35 genetic syndromes associated with glucose intolerance will be discussed below and an attempt will be made to classify them either on the basis of the type of pathogenetic mechanism resulting in the abnormality in glucose tolerance or on the basis of the associated anomalies (Table1).

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References

  1. Alstrom, C.H., Hallgren, B., Nilsson, L. B., Asander, H.: Retinal degeneration combined with obesity diabetes mellitus, and neurogenous deafness. A specific syndrome (not hitherto described) distinct from the Laurence-Moon-Biedl syndrome. A. clinical endocrinological and genetic examination based on a large pedigree. Acta Psychiat. Neurol. Scand. 34, 1 (1959)

    Article  Google Scholar 

  2. Armaly, M.F.: The heritable nature of dexamethasone-induced ocular hypertension. Arch. Ophthal. 75, 32 (1966)

    Article  PubMed  CAS  Google Scholar 

  3. Armaly, M.F.: Dexamethasone ocular hypertension and eosinopenia and glucose tolerance test. Arch. Ophthal. 78, 193 (1967)

    Article  PubMed  CAS  Google Scholar 

  4. Balcerzak, S. P., Mintz, D.H., Westerman, M.P.: Diabetes mellitus and idiopathic hemochromatosis. Amer. J. Med. Sci. 255, 53 (1968)

    Article  PubMed  CAS  Google Scholar 

  5. Ballard, H. S., Frame, B., Hartsock, R. J.: Familial multiple endocrine adenomapeptic ulcer complex. Medicine 43, 481 (1964)

    Article  PubMed  CAS  Google Scholar 

  6. Bottazzo, G. F., Florin-Christensen, A., Doniach, D.: Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2, 1279 (1974)

    Article  PubMed  CAS  Google Scholar 

  7. Bretz, G.W., Baghdassarin, A., Graher, J. D., Zacherle, B. J., Norum, R. A., Blizzard, R.M.: Coexistence of diabetes mellitus and insipidus and optic atrophy in two male siblings. Amer. J. Med. 48, 398 (1970)

    Article  PubMed  CAS  Google Scholar 

  8. Carpenter, C.C.J., Solomon, N., Silverberg, S. G., Bledsoe, T., Northcutt, R.C., Klinenberg, J. R., Bennett, I. L., and Harvey, A.M.: Schmidt’s syndrome (thyroid and adrenal insufficiency): A review of the literature and a report of fifteen new cases including ten instances of coexistent diabetes mellitus. Medicine 43, 153 (1964)

    PubMed  CAS  Google Scholar 

  9. Collip, P.J., Sharma, R.K., Thomas, J., Maddaiah, V.T., Chen, S.Y.: Abnormal glucose tolerance in children with achondroplasia. Am. J. Dis. Child. 124, 682 (1972)

    Google Scholar 

  10. Collis, W.J., Engel, W.K.: Glucose metabolism in five neuromuscular disorders. Neurology 18, 915 (1968)

    Article  PubMed  CAS  Google Scholar 

  11. Cooper, I.S., Rynearson, E.H., Bailey, A.A., MacCarty, C.S.: The relation of spinal cord disease to gynecomastia and testicular atrophy. (Proc. staff meet.). Mayo Clin. 25, 320 (1950)

    CAS  Google Scholar 

  12. Danowski, T.S., Khurana, R.C., Gonzales, A.R., Fisher, E.R.: Capillary basement membrane thickness and the pseudodiabetes of myopathy. Brit. J. Ophthalmol. 51, 757 (1971)

    CAS  Google Scholar 

  13. Davidson, P., Constanza, D., Swieconek, J.A., Harris, J.B.: Hereditary pancreatitis. A kindred without gross aminoaciduria. Ann. Intern. Med. 68, 88 (1968)

    PubMed  CAS  Google Scholar 

  14. Drucker, W.D., Rowland, L.P., Sterling, K., Christy, N.P.: On the function of the endocrine glands in myotonic muscular dystrophy. Amer. J. Med. 31, 941 (1961)

    Article  PubMed  CAS  Google Scholar 

  15. Elders, M. J., Garland, J. T., Daughaday, W.A., Fisher, D. A., Whitney, J. E., Hughes, E. R.: Laron Dwarfism: studies on the nature of the defect. J. Pediat. 83, 253 (1973)

    Article  PubMed  CAS  Google Scholar 

  16. Epstein, C. J., Mertin, G.M., Schultz, A. L., Motulsky, A.G.: Werner’s syndrome. Medicine 45, 117 (1966)

    Google Scholar 

  17. Field, J. B., Loube, S. D.: Observations concerning the diabetes mellitus associated with Werner’s syndrome. Metabolism 9, 118 (1960)

    PubMed  CAS  Google Scholar 

  18. Fraccaro, M., Gastaldi, F.: La patologia della sindrome di Laurence-Moon-Biedl, Folia, Hered. Et Path. 2, 177 (1953)

    Google Scholar 

  19. Fraser, G.R.: Heredity injuvenile diabetes. Brit. Med. J. 1, 433 (1964)

    Article  Google Scholar 

  20. Frey, H.M.M., Vogt, J. H., Nerup, J.: Familial poly-endocrinopathy. Acta Endocr. 72, 401 (1973)

    PubMed  CAS  Google Scholar 

  21. Fujimoto, W.Y., Greene, M. L., Seegmiller, J. E.: Cockayne’s syndrome: report of a case with hyperlipoproteinemia, hyperinsulinemia, renal disease and normal growth hormone. J. Pediat. 75, 881 (1969)

    Article  PubMed  CAS  Google Scholar 

  22. Furukawa, T., Takagi, A., Nakao, K., Tsukagoshi, H., Tsubaki, T.: Hereditary muscular atrophy with ataxia, retinitis pigmentosa, and diabetes mellitus. Neurology 19, 942 (1968)

    Article  Google Scholar 

  23. Gharib, H., Gastineau, C. F.: Coexisting Addison’s disease and diabetes mellitus: report of 24 cases with review of literature. Mayo Clin. Proc. 44, 217 (1969)

    PubMed  CAS  Google Scholar 

  24. Goldstein, J. L., Fialkow, P. J.: The Alstrom syndrome: report of three cases with further delineation of the clinical, pathophysiological, and genetic aspects of the disorder. Medicine 52, 53 (1973)

    Article  PubMed  CAS  Google Scholar 

  25. Gorden, P., Griggs, R. C., Nissley, S. P., Roth, J., Engel, W.K.: Studies of plasma insulin in myotonic dystrophy. J. Clin. Endoer. 29, 684 (1969)

    Article  Google Scholar 

  26. Gross, J. B., Gambill, E. E., Ulrich, J. A.: Hereditary pancreatitis. Description of a fifth kindred and summary of clinical features. Amer. J. Med. 33, 358 (1962)

    Article  PubMed  CAS  Google Scholar 

  27. Handwerger, S., Roth, J., Gordon, P., di Sant Agnese, P., Carpenter, D. F., Peter, G.: Glucose intolerance in cystic fibrosis. New Eng. J. Med. 281, 451 (1969)

    Article  PubMed  CAS  Google Scholar 

  28. Herrmann, C., Jr., Augilar, M. J., Sacks, O.W.: Hereditary photomyoclonus associated with diabetes mellitus, deafness, nephropathy, and cerebral dysfunction. Neurology 14, 212 (1964)

    Article  PubMed  Google Scholar 

  29. Herschberg, A. D., Coirault, R., Giboudeau, J.: Le metabolisme du glucose dans la myopathie progressive de Duchenne. Ann. Endocr. 25, 447 (1964)

    PubMed  CAS  Google Scholar 

  30. Hewer, R. L., Robinson, N.: Diabetes mellitus in Friedreich’s ataxia. J. Neurol. Neurosurg. Psychiat. 31, 226 (1968)

    Article  PubMed  CAS  Google Scholar 

  31. Heycock, J. E., Wilson, J.: Diabetes mellitus in a child showing features of Refsum’s syndrome. Arch. Dis. Child. 33, 320 (1958)

    Article  PubMed  CAS  Google Scholar 

  32. Holsclaw, D. S., Auruskin, T., Soeldner, S. J., Schwachman, H.: The development of diabetes mellitus in cystic fibrosis. Abstracts of the Annual Meeting, Society for Pediatric Research, 1970

    Google Scholar 

  33. Howell, R. R., Ashton, D.M., Wyngaarden, J. B.: Clucose-6-phosphate deficiency glycogen storage disease. Pediatrics 29, 553 (1962)

    PubMed  CAS  Google Scholar 

  34. Huff, T. A., Horton, E. S., Lebovitz, H.E.: Abnormal insulin secretion in myotonic dystrophy. New Eng. J. Med. 277, 837 (1967)

    Article  PubMed  CAS  Google Scholar 

  35. Huff, T. A., Lebovitz, H. E.: Dynamics of insulin secretion in myotonic dystrophy. J. Clin. Endocr. 28, 992 (1968)

    Article  PubMed  CAS  Google Scholar 

  36. Ikkos, D.G., Fraser, G.R., Matsouki-Gavra, Petrochilos, M.: Association of juvenile diabetes mellitus, primary optic atrophy and perceptive hearing loss in three sibs, with additional idiopathic diabetes mellitus insipidus in one case. Acta Endocrinologia 65, 95 (1970)

    CAS  Google Scholar 

  37. Ionasecu, V., and Luca, N.: Investigations on carbohydrate metabolism in progressive muscular dystrophy. Psychiat. Neurol. 146, 309 (1963)

    Article  Google Scholar 

  38. Jarnerot, G.: Diabetes mellitus with optic atrophy-thaiassemia-like sideroblastic anemia and weak isoagglutinins — a new genetic syndrome. Acta Med. Scand. 193, 359 (1973)

    Article  PubMed  CAS  Google Scholar 

  39. Klein, D., Ammann, F.: The syndrome of Laurence-Moon-Bardet-Biedl and allied diseases in Switzerland. J. Neurol. Sci. 9, 479 (1969)

    Article  PubMed  CAS  Google Scholar 

  40. Kolodny, E. H., Hass, W.K., Lane, B., Drucker, W.D.: Refsum’s syndrome. Arch. Neurol. 12, 583 (1965)

    Article  PubMed  CAS  Google Scholar 

  41. Lancet Editorial: Autoimmune diabetes mellitus. Lancet II, 1549 (1974)

    Google Scholar 

  42. Landwirth, J., Schwartz, H., Grunt, J. A.: Prader-Willi syndrome. Amer. J. Dis. Child. 116, 211 (1968)

    PubMed  CAS  Google Scholar 

  43. Laron, E., Karp, M., Pertzelan, A., Kauli, R., Keret, R., Doron, M.: The syndrome of familial dwarfism and high plasma immunoreactive human growth hormone (IRHGH). In: Growth and Growth Hormone.Pecile, A. Muller, E. (eds.). Amsterdam:Excerpta Medica, 1972, p. 458

    Google Scholar 

  44. Lee, F. I., Hughes, D. T. D.: Systemic effects in dystrophia myotonica. Brain 87, 521 (1964)

    Article  PubMed  CAS  Google Scholar 

  45. Levine, M., Rimoin, D.L., Bray, G.A.: Glucose tolerance in achondroplasia. In preparation

    Google Scholar 

  46. Lippe, B., Sperling, M.A., Dooley, R.: Pancreatic alpha and beta cell function in children with cystic fibrosis. Pediat. Res. 8, 435 (1974)

    Article  Google Scholar 

  47. Lockwood, D.H., Merimee, T. J., Edgar, P. J., Greene, M.D., Fujimoto, W.Y., Seegmiller, J. E., Howell, R.R.: Insulin secretion in type I glycogen storage disease. Diabetes 18, 755 (1969)

    PubMed  CAS  Google Scholar 

  48. Loridan, L., Sadeghi-Nejad, A., Senior, B.: Hypersecretion of insulin after the administration of L-leucine to obese children. J. Pediat. 78, 53 (1971)

    Article  PubMed  CAS  Google Scholar 

  49. Lynch, H. T., Kaplan, A. R., Henn, J. J., Krush, A. J.: Familial coexistence of diabetes mellitus, hyperlipemia, short stature, and hypogonadism. Amer. J. Med. Sci. 252, 323 (1966)

    Article  PubMed  CAS  Google Scholar 

  50. MacCuish, A. C., Barnes, E.W., Irvine, W.J., Duncan, L. J. P.: Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease. Lancet 2, 1529 (1974)

    Article  PubMed  CAS  Google Scholar 

  51. MacDonald, W.B., Fitch, K. D., Lewis, I. C.: Cockayne’s syndrome, a heredo-familial disorder of growth and development. Pediatrics 25, 996 (1960)

    Google Scholar 

  52. McFarlin, D. E., Strober, W., Waldmann, T.A.: A taxia telangiectasia. Medicine 51, 281 (1972)

    Article  PubMed  CAS  Google Scholar 

  53. Mendenhall, E. N.: Tumor of the pineal body with high insulin resistance. J. Indiana Med. Assoc. 43, 22 (1950)

    Google Scholar 

  54. Merimee, T. J., Fineberg, S. E., McKusick, V.A., Hall, J.: Diabetes mellitus and sexual a teliotic dwarfism: a comparative study. J. Clin. Invest. 49, 1096 (1970)

    Article  PubMed  CAS  Google Scholar 

  55. Merimee, T. J., Siperstein, M.D., Hall, J. D., Fineberg, S. E.: Capillary basement membrane structure: a comparative study of diabetics and sexual a teliotic dwarfs. J. Clin. Invest. 49, 2161 (1970)

    Article  PubMed  CAS  Google Scholar 

  56. Milner, A.D.: Blood glucose and serum insulin levels in children with cystic fibrosis. Arch. Dis. Child. 44, 351 (1969)

    Article  PubMed  CAS  Google Scholar 

  57. Najjar, S. S., Mahmud, J.: Diabetes insipidus and diabetes mellitus in a six-year-old girl. J. Pediat. 73, 251 (1968)

    Article  PubMed  CAS  Google Scholar 

  58. Nakano, K. K., Dawson, D.M., Spence, A.: Machado disease. A hereditary ataxia in Portuguese emigrants to Massachusetts. Neurology 22, 49 (1972)

    Article  PubMed  CAS  Google Scholar 

  59. Neill, C.A., Dingwall, M.M.: A syndrome resembling progeria: a review of two cases. Arch. Dis. Child. 25, 213 (1950)

    Article  PubMed  CAS  Google Scholar 

  60. Niemeyer, G., Marquardt, J. L.: Retinal function in an unique syndrome of optic atrophy, juvenile diabetes mellitus, diabetes insipidus, neurosensory hearing loss, autonomic dysfunction, and hyperalanineuria. Invest. Ophthal. 11, 617 (1972)

    PubMed  CAS  Google Scholar 

  61. Podolsky, S., Leopold, N. A., Sax, D. S.: Increased frequency of diabetes mellitus in patients with Huntington’s chorea. Lancet I, 1356 (1972)

    Article  Google Scholar 

  62. Podolsky, S., Sheremata, W.A.: Insulin dependent diabetes mellitus and Friedreich’s ataxia. Metabolism 19, 555 (1970)

    Article  PubMed  CAS  Google Scholar 

  63. Prader, A., Labhart, A., Willi, H.: Ein Syndrom von Adipositas, Kleinwuchs, Kryptorchidismus und Oligophrenia nach myotonieartigem Zustand im Neugeborenenalter. Schweiz. Med. Wschr. 86, 1260 (1956)

    Google Scholar 

  64. Rabson, S.M., Mendenhall, E. N.: Familial hypertrophy of pineal body, hyperplasia of adrenal cortex and diabetes mellitus. Amer. J. Clin. Path. 26, 283 (1956)

    CAS  Google Scholar 

  65. Raibi, S., Plotkin, S., Newns, G.H.: Diabetes mellitus and insipidus in two sisters. Brit. Med. J. 2, 1625 (1963)

    Article  Google Scholar 

  66. Rimoin, D. L.: Genetics of Diabetes Mellitus. Diabetes 16, 346 (1967)

    PubMed  CAS  Google Scholar 

  67. Rimoin, D. L.: The Chondrodystrophies. Advances in Human Genetics 5, 1 (1975)

    PubMed  CAS  Google Scholar 

  68. Rimoin, D. L., Schechter, J. E.: Histological and ultrastructural studies in isolated growth hormone deficiency. J. Clin. Endocrinol. Metab. 37, 725 (1973)

    Article  PubMed  CAS  Google Scholar 

  69. Rimoin, D. L., Schimke, R.N.: Genetic Disorders of the Endocrine Glands. St Louis: C.V. Mosby, 1971

    Google Scholar 

  70. Rorsman, G., Soderstrom, N.: Optic a trophy and juvenile diabetes mellitus with familial occurrence. Acta Med. Scand. 182, 419 (1967)

    Article  PubMed  CAS  Google Scholar 

  71. Rose, F. G., Fraser, G.R., Friedmann, A. I., Kohner, E. M.: The association of juvenile diabetes mellitus and optic atrophy. Quart. J. Med. 35, 385 (1966)

    PubMed  CAS  Google Scholar 

  72. Royer, P.: Le diabète sucré dans le syndrome de Willi-Prader. Journees Ann. Diabet. Hotel Dieu 4, 91 (1963)

    Google Scholar 

  73. Saddi, R., Peingold, J.: Idiopathic haemochromatosis and diabetes mellitus. Clin. Gen. 5, 242 (1974)

    Article  CAS  Google Scholar 

  74. Savir, A., Dickerman, Z., Karp, M., Laron, Z.: Diabeti cretinopathy in an adolescent with Prader-Labhart-Willi syndrome. Arch. Dis. Child. 49, 963 (1974)

    Article  PubMed  CAS  Google Scholar 

  75. Schalch, D. S., McFarlin, D. E., Barlow, M.H.: An unusual form of diabetes mellitus in ataxia telangiectasia. New Eng. J. Med. 282, 1396 (1970)

    Article  PubMed  CAS  Google Scholar 

  76. Solis-Cohen, S., Weiss, E.: Dystrophia adiposogenitalis, with atypical retinitis pigmentosa and mental deficiency — the Laurence-Biedl syndrome. Amer. J. Med. Sci. 169, 489 (1925)

    Article  Google Scholar 

  77. Spark, H.: Cachectic dwarfism resembling the Cockayne-Neill type. J. Pediat. 66, 41 (1965)

    Article  PubMed  CAS  Google Scholar 

  78. Spergel, G., Bleicher, S. J., Ertel, N.H.: Carbohydrate and fat metabolism in patients with pheochromocytoma. New Eng. J. Med. 278, 803 (1968)

    Article  PubMed  CAS  Google Scholar 

  79. Stahl, M., Girard, J., Rutishauser, M., Nars, P.W., Zuppinger, K.: Endocrine function of the pancreas in cystic fibrosis: evidence for an impaired glucagon and insulin response following arginine infusion. J. Pediat. 84, 821 (1974)

    Article  PubMed  CAS  Google Scholar 

  80. Stimmler, L., Jensen, N., Toseland, P.: Alaninuria, associated with microcephaly, dwarfism, enamel hypoplasia, and diabetes mellitus in two sisters. Arch. Dis. Child. 45, 682 (1970)

    Article  PubMed  CAS  Google Scholar 

  81. Swash, M., van den Noort, S., Craig, J.W.: Late-onset proximal myopathy with diabetes mellitus in four sisters. Neurology 20, 694 (1970)

    Article  PubMed  CAS  Google Scholar 

  82. Thoren, C.: Diabetes mellitus in Friedreich’s ataxia. Acta Paediatrica 51, 239 (1962)

    Article  Google Scholar 

  83. De Fraites, E. B., Thurmon, T. F. and Farbadian, H.: Familial Prader-Willi syndrome. In: Genetic Forms of Hypogonadism, Birth Defects Original Article Series. XI (4): 123, 1975

    Google Scholar 

  84. Tunbridge, R. E., Paley, R.G.: Primary optic atrophy in diabetes mellitus. Diabetes 5, 295 (1956)

    PubMed  Google Scholar 

  85. Vance, J. E., Buchanan, K. D., O’Hara, D., Williams, R.H., Porte, D.: Insulin and glucagon responses in subjects with pheochromocytoma: effects of alpha adrenergic blockade. J. Clin. Endocr. 29, 911 (1969)

    Article  PubMed  CAS  Google Scholar 

  86. Wang, C. I.: Intertwining genetics of cystic fibrosis and diabetes mellitus. Abstracts of the Eighth Annual Meeting of Cystic Fibrosis Club, National Cystic Fibrosis Research Foundation, New York, 1967

    Google Scholar 

  87. Waxman, A. D., Schalch, D. S., Odell, W.D., Tschudy, D. P.: Abnormalities of carbohydrate metabolism in acute intermittent porphyria. J. Clin. Invest. 46, 1129 (1967)

    Google Scholar 

  88. Waxman, A. D., Berk, P., Schalch, D., Tschudy, D.: Isolated adrenocorticotrophic hormone deficiency in acute intermittent porphyria. Ann. Intern. Med. 70, 317 (1969)

    PubMed  CAS  Google Scholar 

  89. Weinstein, R. L., Kliman, B., Scully, R. E.: Familial syndrome of primary testicular insufficiency with normal virilization, blindness, deafness, and metabolic abnormalities. New Eng. J. Med. 281, 969 (1969)

    Article  PubMed  CAS  Google Scholar 

  90. Welsh, D.: Study of a family with a new progeroid syndrome. In: New Chromosomal and Malformation Syndromes, Birth Defects Original Article Series. XI (5): 25, 1975

    Google Scholar 

  91. Whitten, D.M., Feingold, M., Eisenklam, E. J.: Hereditary pancreatitis. Amer. J. Dis. Child. 116, 426 (1968)

    PubMed  CAS  Google Scholar 

  92. Wilber, J. F., Turtle, J.R., Crane, N. A.: Inhibition of insulin secretion by a pheochromocytoma. Lancet 2, 733 (1966)

    Article  PubMed  CAS  Google Scholar 

  93. Wolcott, C. D., Rallison, M. L.: Infancy-onset diabetes mellitus and multiple epiphyseal dysplasia. J. Pediat. 80, 292 (1972)

    Article  PubMed  CAS  Google Scholar 

  94. Wolfram, D. J.: Diabetes mellitus and simple optic atrophy among siblings: report of four cases. (Proc. staff meet. Mayo Clin.) 13, 715 (1938)

    Google Scholar 

  95. Zellweger, H., Schneider, H. J.: Syndrome of hypotonia-hypomentia-hypogonadism obesity (HHHO) or Prader-Willi syndrome. Arch. Dis. Child. 115, 588 (1968)

    CAS  Google Scholar 

  96. Zucker-Franklin, D., Rifkin, H., Jacobson, H. G.: Werner’s syndrome. An analys is of ten cases. Geriatrics 23, 123 (1968)

    PubMed  CAS  Google Scholar 

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  1. D. L. Rimoin
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  1. Medizinische Klinik und Poliklinik der Universität, Humboldtallee, 1, D-3400, Göttingen, Germany

    Werner Creutzfeldt  & Johannes Köbberling  & 

  2. Department of Human Genetics, 1137 E Catherine Street, Ann Arbor, MI, 48104, USA

    James V. Neel

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Rimoin, D.L. (1976). Genetic Syndromes Associated with Glucose Intolerance. In: Creutzfeldt, W., Köbberling, J., Neel, J.V. (eds) The Genetics of Diabetes Mellitus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66332-1_7

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