Etiological and Promoting Factors in the Pathogenesis of Diabetes Mellitus

  • W. Creutzfeldt


Despite the fact — known for centuries — that diabetes mellitus is a familial disease, the genetics of this disease are still poorly understood. The most important hindrance to a proper genetic study is the fact that the basic defect in diabetesis unknown. Therefore, no method exists for detecting individuals who possess the diabetic genotype but who have, as yet, no signs of abnormal carbohydrate metabolism (11). The clinical syndrome called diabetesis complex and any search for a common etiological factor may over simplify the problem. However, many studies have shown that a subject with diabetes releases after glucose load too little insulin too late relative to a comparable but nondiabetic individual. Thus, an abnormality in the pancreatic B-cell appears central to the disease and the most simple definition of diabetes is absolute or relative insulin deficiency.


Insulin Requirement Spiny Mouse Spontaneous Diabetes Common Etiological Factor Relative Insulin Deficiency 
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  1. 1.
    Cahill, G.F.: Diabetes, insulin and future developments. In: Diabetes. Proceedings of the VTIIth Congress of the IDF. Malaisse, W.J. Pirart, J. (eds.). Amsterdam: Excerpta Medica, 1974, p. 53Google Scholar
  2. 2.
    Cameron, D. P., Opat, F., Insch, S., Lovell-Smith, C. J., Insch, J. G. T.: Studies of immunoreactive insulin secretion in NZO mice in vivo. Diabetologia 10, 649 (1974)PubMedCrossRefGoogle Scholar
  3. 3.
    Cerasi, E.: Mechanisms of glucose-stimulated insulin secretion in health and in diabetes: some re-evaluations and proposals. The Minkowski Award Lecture 1974. Diabetologia 11, 1 (1975)PubMedCrossRefGoogle Scholar
  4. 4.
    Graighead, J. E.:Viral lesions on the pancreatic islets of Langerhans. In: Diabetes. Proceedings of the VTIIth Congress of the IDF.Malaisse, W.J. Pirart, J. (eds.). Amsterdam: Excerpta Medica, 1974, p. 287Google Scholar
  5. 5.
    Creutzfeldt, W.: The relationship between etiological and promoting factors in the pathogenesis of diabetes mellitus in man and animals. Acta diabetol. lat. 7, 341 (1970)Google Scholar
  6. 6.
    Frankel, B. J., Gerich, J. E., Hagura, R., Fanska, R. E., Gerritsen, G.C., Grodsky, G.M.: Abnormal secretion of insulin and glucagon by the in vitro perfused pancreas of the genetic ally diabetic Chinese hamster. J. Clin. Invest. 53, 1637 (1974)PubMedCrossRefGoogle Scholar
  7. 7.
    Gamble, D. R., Kinsley, M.L., Fitzgerald, M.G., Bolton, R., Taylor, K.W.: Viral antibodies in diabetes mellitus.Brit. Med. J. 1969, 3, 627PubMedCrossRefGoogle Scholar
  8. 8.
    Gerich, J. E., Lorenzi, M., Schneider, V., Karam, J. H., Rivier, J., Guillemin, R., Forsham, P. H.: Effects of somatostatin on plasma glucose and glucagon levels in human diabetes mellitus. New Engl. J. Med. 291, 544 (1974)PubMedCrossRefGoogle Scholar
  9. 9.
    Gerritsen, G.C., Blanks, M.C., Miller, R. L., Dulin, W.E.: Effect of diet limitation on the development of diabetes in prediabetic Chinese hamsters, Diabetologia 10, 559 (1974)PubMedCrossRefGoogle Scholar
  10. 10.
    Iwatsuka, H., Taketomi, S., Matsuo, T., Suzuoki, Z.: Congenitally impaired hormone sensitivity of the adipose tissue of spontaneously diabetic mice, KK. Validity of thrifty genotype on the KK mice. Diabetologia 10, 611 (1974)PubMedCrossRefGoogle Scholar
  11. 11.
    Johansen, K., Soeldner, J.S., Gleason, R. E.: Insulin, growth hormone and glucagon in prediabetes mellitus — a review. Metabolism 23, 1185 (1974)PubMedCrossRefGoogle Scholar
  12. 12.
    Like, A.A., Chick, W.L.: Studies in the diabetic mutant mouse: I + II: Light microscopy, radioautography and electron microscopy of pancreatic islets. Diabetologia 6, 207 and 216 (1970)Google Scholar
  13. 13.
    Malaisse-Lagae, F., Rawazola, M., Amherdt, M., Gutzeit, A., Stauffacher, W., Mdlaisse, W.J., Orci, L.: An apparent abnormality of the B-cell microtubular system in spiny mice (acomys cahirinus). Diabetologia 11, 71 (1975)Google Scholar
  14. 14.
    Renold, A. E., Rabinovitch, A., Wollheim, C.B., Kikuchi, M., Gutzeit, A. H., Amherdt, M., Malaisse-Lagae, F., Orci, L.: Spontaneous and experimental diabetic syndromes in animals. Are — evaluation of their usefulness for approaching the physiopathology of diabetes. In: Diabetes. Proc. VIIIth Congr. IDF. Malaisse, W.J. Pirart, J. (eds.). Amsterdam, Excerpta Medica, 1974, p. 22Google Scholar
  15. 15.
    Unger, R.H.: Alpha- and beta-cell interrelationship in health and disease. Metabolism, 23, 581 (1974)PubMedCrossRefGoogle Scholar
  16. 16.
    Unger, R. H., Orci, L.: The essential role of glucagon in the pathogenesis of diabetes mellitus. Lancet I, 14 (1975)CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1976

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  • W. Creutzfeldt

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