Abstract
The long-term diabetic syndrome,as described in the early 1950s by Lundbaek (48), is to a large extent dominated by vascular complications, often in combination with symptoms of neuropathy. Today these late clinical manifestations of widespread vascular involvment, affecting both the large vessels and the capillary system constitute the most serious problem for the patient with diabetes mellitus, threatening his well-being and his life.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aarseth, S.: Lipoatrophic diabetes (abstract). Diabetologia 3, 535 (1967)
Arnold, J.D., Tarlov, A.R., Spargo, B., Brewer, G.J.: Subclinical diabetes mellitus in patients presenting with clinical chronic “glomerulonephritis”. Trans. Assoc. Am. Phys. 71, 186 (1958)
Becker, D., Miller, M.: Presence of diabetic glomerulosclerosis in patients with hemochromatosis. New Eng. J. Med. 263, 367 (1960)
Bell, E.T.: Relation of portal cirrhosis to hemochromatosis and to diabetes mellitus. Diabetes 4, 435 (1955)
Bloodworth, J.M.B., Jr., Engerman, R.L.: Spontaneous and induced diabetic microangiopathy. In: Acta Diabetologica Latina, Suppl. 1. Blood Vessel Disease in Diabetes Mellitus. Lundbaek, K., Keen, H. (eds.). Milano: The Publishing House “II Ponte”, 1971, Vol. VIII, p. 263
Bloodworth, J.M.B., Jr., Engerman, R.L., Anderson, P. J.: Microangiopathy in experimentally diabetic animal. In: Advances in Metabolic Disorders: Vascular and Neurological Changes in Early Diabetes, Suppl. 2. Camerini-Davalos, R.A., Cole, H.S. (eds.). New York, London: Academic Press, 1973, p. 245
Burton, T.Y., Kearns, T.P., Rynearson, R.H.: Diabetic retinopathy following total pancreatectomy. Proc. Mayo Clin. 32, 735 (1957)
Caird, F. I., Pirie, A., Ramsell, T.G.: Diabetes and the eye. Edinburgh: Blackwell scientific publications, 1968, p. 78
Cameron, D.P., Amherdt, M., Leuenberger, P., Orci, L., Stauffacher, W.: Microvascular alterations in chronically streptozotocin-diabetic rats. In: Advances in Metabolic Disorders: Vascular and Neurological Changes in Early Diabetes, Suppl. 2. Camerini-Davalos, R.A., Cole, H.S. (eds.). New York, London: Academic Press, 1973, p. 257
Creutzfeldt,W.: Der Diabetes des pancreaslosen Menschen. In: Handbuch des Diabetes Mellitus. Pfeiffer, E.F. (ed.). München: Lehmanns Verlag, 1971, Vol. II, p. 239
Danowski, T. S., Khurana, R.C., Gonzalez, A.R., Fisher, E.R.: Capillary basement membrane thickness and the pseudodiabetes of myopathy. Am. J. Med. 51, 757 (1971)
Danowski, T. S., Fisher, E.R., Khurana, R.C., Nolan, S., Stephan, T.: Muscle capillary basement membrane in juvenile diabetes mellitus. Metabolism 21, 1125 (1972)
Deckert, T.: Late diabetic manifestations in pancreatogenic diabetes mellitus. Acta Med. Scand. 168, 439 (1960)
Derot, M., Bour, H., Tutin, M., Guy-Grand, B.: Diabète sucrá et pancréatite chronique. Le Diabète 18, 93 (1970)
Doyle, A.P., Balcerzak, S. P., Geffrey, W.L.: Fatal diabetic glomerulosclerosis after total pancreatectomy. New Eng. J. Med. 270, 623 (1964)
Duncan, L. J. P., Mac Farlane, A., Robson, J. S.: Diabetic retionpathy and nephropathy in pancreatic diabetes. Lancet I, 822 (1958)
Dymock, I.W., Cassar, J., Pyke, D.A., Oakley, W.G., Williams, R.: Observations on the pathogenesis, complications and treatment of diabetes in 115 cases of hemochromatosis. Am. J. Med. 52, 203 (1972)
Ellenberg, M.: Diabetic nephropathy without manifest diabetes. Diabetes 11, 197 (1962)
Engerman, R.L., Bloodworth, J.M.B., Jr.: Experimental diabetic retinopathy in dogs. Arch. Ophthal. 73, 205 (1965)
Fajans, S. S., Gonn, J.W.: Tolbutamide-induced improvement in carbohydrate tolerance of young people with mild diabetes mellitus. Diabetes 9, 83 (1960)
Fajans, S. S., Wiliamson, J.R., Weissman, P.N., Vogler, N.J., Kilo, C., Conn, J.W.: Basement membrane thickening in latent diabetes. In: Advances in Metabolic Disorders: Vascular and Neurological Changes in Early Diabetes. Camerini-Davalos R.A., Cole, H.S. (eds). New York, London: Academic Press, 1973, p. 393
Galton, D. J.: Diabetic retinopathy and haemochromatosis. Brit. Med. J. 1, 1169 (1965)
Griffiths, J. D., Dymock,I.W., Davies, E.W.G., Hill, D.W., Williams, R.: Occurrence and prevalence of diabetic retinopathy in hemochromatosis. Diabetes 20, 766 (1971)
Gundersen, H.J.G., Østerby, R.: Statistical analysis of transformations leading to normal distribution of measurements of the peripheral glomerular basement membrane. J. Microsc. 97, 293 (1973)
Hamwi, G.J., Kruger, F.A., Eymontt, M.J., Scarpelli, D.G., Gwinup, G., Byron, R. Lipoatrophic diabetes. Diabetes 15, 262 (1966)
Hirose, K.: Clinical and pathological features of diabetic nephropathy in Japanese diabetic patients. In: Diabetes Mellitus in Asia, 1970. Tsuji, S., Wada, M. (eds.). Amsterdam: Excerpta Medica, 1971, p. 177
Hägg, E.: Renal lesions in rats with long-term alloxan diabetes. Acta Path. Microbiol. Scand. Section A. 82, 199 (1974)
Hägg, E.: Glomerular basement membrane thickening in r a t s with long-term alloxan diabetes. Acta Path. Microbiol. Scand. Section A. 82, 211 (1974)
Hägg, E.: Influence of insulin treatment on glomerular changes in rats with long term alloxan diabetes. Acta Path. Microbiol. Scand. Section A. 82, 228 (1974)
Ireland, J. T., Patnaik, B.K., Duncan, L. J. P.: Glomerular ultrastructure in secondary diabetics and normal subjects. Diabetes 16, 628 (1967)
Ireland, J. T.: Diagnostic criteria in the assessment of glomerular capillary basement membrane lesions in newly diagnosed juvenile diabetics. In: Advances in Metabolic Disorders: Early Diabetes, Suppl. 1. Camerini-Davalos, R.A., Cole, H.S. (eds.). New York, London: Academic Press, 1970, p. 273
Jackson, W.P.U., Goldberg, M.D., Major, V., Campbell, G.D.: Vascular and other diabetes-related disorders among natal Indian diabetics and nondiabetics. S. Afr. Med. J. 44, 279 (1970)
Jackson, W.P.U.: Diabetes mellitus in different countries and different races. Prevalence and major features. Acta Diabet. Lat. 7, 361 (1970)
Johansen, K.: Plasma insulin in diabetes mellitus and obesity. A review. FADL’s forlag. Copenhagen: Arhus, Odense, 1975
Kamenetzky, S.A., Bennett, P.H., Dippe, S.E., Miller, M., LeCompte, P.M.: A clinical and histologic study of diabetic nephropathy in the Pima Indians. Diabetes 23, 61 (1974)
Kaplan, M.H., Feinstein, A.R.: A critique of methods in reported studies of long-term vascular complications In patients with diabetes mellitus. Diabetes 22, 160 (1973)
Kimmelstiel, P., Kim, O. J., Beres, J.: Studies on renal biopsy specimens with the aid of the electron microscope. I. Glomeruli in diabetes. Am. J. Clin. Pathol 38, 270 (1962)
Kimmelstiel, P., Osawa, G., Beres, J.: Glomerular basement membrane in diabetics. Am. J. Clin. Pathol. 45, 21 (1966)
Kniffen, J.C., Quick, D.T.: Carbohydrate abnormalities in amyotrophic lateral sclerosis. In: Muscle Disease. Walton, J.N., Cenal, N., Scarlato, G. (eds.). Amsterdam: Excertpa Med., 1970, p. 345
Knowles, H.C.: Control of diabetes and the progression of vascular disease. In: Diabetes Mellitus. Theory and Practice. Ellenberg, M., Rifkin, H. (eds.). New York: McGraw-Hill, 1970, p. 666
Kojima, K.: Electron microscopic studies on the retina and choroid in alloxan-rats. Acta Societatis Ophth. Japonicae 75, 1698 (1971)
Kornerup, T.: Studies in diabetic retinopathy. An investigation of 1000 cases of diabetes. Acta Med. Scand. 153, 81 (1955)
Kreines, K., Kim, O., Knowles, H.C.: Glomerulosclerosis, hemochromatosis, and diabetes mellitus. Am. J. Clin. Path. 54, 47 (1970)
Lazarow, A.: Glomerular basement membrane thickening in diabetes. In: Diabetes. Proc. 6th Cong. Internat. Diab. Fed. Östman, J., Milner, R.D.G. (eds.). Stockholm Amsterdam: Excerpta Med. Found., 1969, p. 301
Lee, C.S., Mauer, S.M., Brown, D.M., Sutherland, D.E.R., Michael, A.F., Najarian, J. S.: Renal transplantation in diabetes mellitus in rats. J. Exp. Med. 139, 793 (1974)
Leuenberger, P., Cameron, D., Stauffacher, W., Renold, A.E., Babel, J.: Ocular lesions in rats rendered chronically diabetic with streptozotocin. Ophthal. Res. 2, 189 (1971)
Lonergan, P., Robbins, S. L.: Absence of intercapillary glomerulosclerosis in the diabetic patient with hemochromatosis. New Eng. J. Med. 260, 367 (1959)
Lundbaek, K.: Long-term diabetes. Copenhagen: Munksgaard, 1953
Lundbaek, K.: Diabetic retinopathy in newly diagnosed diabetes mellitus. Acta Med. Scand. 521, 53 (1955)
Lundbaek, K., Steen-Olsen, T., Ørskov, H., Østerby-Hansen, R.: Long-term experimental insulin-deficiency diabetes. A model of diabetic angiopathy? Acta Med. Scand., Suppl. 476, 159 (1967)
Marcus, R.: Retinopathy, nephropathy, and neuropathy in lipoatrophic diabetes. Case report and discussion. Diabetes 15, 351 (1966)
Matras, A., Kohler, J.: Ein Beitrag zum Werner-syndrom. Wien Med. Wschr. 106, 437 (1956)
Mauer, S.M., Michael, A.F., Fish, A. J., Brown, D.M.: Spontaneous immunoglobulin and complment deposition in glomeruli of diabeticrats. Lab. Invest. 27, 488 (1972)
Mauer, S.M., Sutherland, D.E.R., Steffes, M.W., Leonard, R.J., Najarian, J. S., Michael, A.F., Brown, D.M.: Pancreatic islet transplantation. Effects on the glomerular lesions of experimental diabetes in the onset. Diabetes 23, 748 (1974)
Pardo, V., Perez-Stable, E., Alzamora, D.B., Cleveland, W. W.: Incidence and significance of muscle capillary basal lamina thickness in juvenile diabetes. Am. J. Pathol. 68, 67 (1972)
Pirat, J., Barbier, P.: Effet protecteur de L’hémochromatose vis-á-vis des lésions vasculaires séniles ou diabétiques. Diabetologia 7, 227 (1971)
Pyke, D.A., Roberts, D.St.C.: Retinopathy in early cases of diabetes mellitus. Acta Med. Scand. 163, 489 (1959)
Rimoin, D.L.: The genetics of diabetes mellitus. In: Diabetes Mellitus: Theory and Practice. Ellenberg, M., Rifkin, H. (eds.). New York: McGraw-Hill, 1970, p. 564
Rosenbloom, A.L.: The natural history of diabetes mellitus. Pub. Health Reviews 2, 115 (1973)
Sevel, D., Bristow, J.H., Bank, S., Marks, I., Jackson, P.: Diabetic retinopathy in chronic pancreatitis. Arch. Ophth. 83, 245 (1971)
Shapiro, F.L., Smith, H.T.: Diabetic glomerulosclerosis in a patient with chronic pancreatitis. Arch. Intern. Med. 117, 795 (1966)
Siperstein, M.D.: Capillary basement membranes and diabetic microangiopathy. Adv. Intern. Med. 18, 325 (1972)
Sprague, R.G.: Diabetes mellitus associated with chronic relapsing pancreatitis. Proc. Staff Meet. Mayo Clin. 22, 553 (1947)
Steiner, H.: Das Prader-Labhart-Willi-Syndrom. Eine morphologische Analyse. Virchows Arch. 345, 205 (1968)
West, K.M.: Diabetes in American Indians and other native populations of the New World. Diabetes 23, 841 (1974)
Williamson, J.R., Vogler, N. J., Kilo, C.: Basement membrane thickening in muscle capillaries. Observations on diabetics and nondiabetics with both parents diabetics. In: Endocrinology. Proc. 4th Internat. Congr. Endocrinol., Wash. D.C., 1972. Internat. Congr. Series no. 273. Srow, R.O., Ebling, P.I.G., Henderson, I.W. (eds.). Amsterdam: Excerpta Med., 1973, p. 1122
Williamson, J. R., Vogler, N., Kilo, C.: The natural history of basement membrane disease in diabetes mellitus. In.: Diabetes. Proc. 8th Congr. Internat. Diab. Fed. Brussels, 1973. Internat. Congr. Series no. 312. Malaisse, W.J., Pirart,J. (eds.). Amsterdam: Excerpta Med., 1974, p. 424
Ørskov, H., Olsen, T.S., Nielsen, K., Rafaelsen, O.J., Lundbaek, K. : Kidney lesions in rats with severe long-term alloxan diabetes. I. Influence of age, alloxan damage, and insulin administration. Diabetologia I, 172 (1965)
Østerby, R.: Early phases in the development of diabetic glomerulopathy. A quantitative electron microscopic study. Acta Med. Scand., Suppl. 574 (1975)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Østerby, R. (1976). Microangiopathy in Diabetics of Different Etiologies. In: Creutzfeldt, W., Köbberling, J., Neel, J.V. (eds) The Genetics of Diabetes Mellitus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66332-1_21
Download citation
DOI: https://doi.org/10.1007/978-3-642-66332-1_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-07651-3
Online ISBN: 978-3-642-66332-1
eBook Packages: Springer Book Archive