Hereditary Hyperglycemic Syndromes in Laboratory Rodents

  • W. Stauffacher
  • R. Kikkawa
  • M. Amherdt
  • L. Orci

Abstract

The subject of the hereditary hyperglycemic syndromes occurring in laboratory rodents and of their potential usefulness as “models” for the study of human diabetes has received much attention in recent years. Thus, at least three entire workshops and several extensive reviews were devoted to this topic during the last few years (1,2,9,14,15,17,20). For this reason, the present discussion will be limited to a brief review of current knowledge concerning the genetic transmission of some of the animal syndromes and to a description of their clinical course and of insulin-secretory patterns and pancreatic anomalies apparently characteristic for some of them. Finally, these observations will be related to more recent findings suggesting that such apparent pancreatic anomalies need not to be the primary hereditary defect responsible for the occurrence of the syndrome but that they may merely represent a characteristic feature of the genetic background of the animal carrying the “diabetogenic” gene (9,12).

Keywords

Obesity Hyperglycemia Doyle 

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References

  1. 1.
    Bray, G.A., York, D.A.: Genetically transmitted obesity in rodents. Physiol. Rev. 11, 598 (1971)Google Scholar
  2. 2.
    Cameron, D. P., Stauffacher, W., Renold, A. E.:Spontaneous hyperglycemia and obesity in laboratory rodents. In:Handbook of Physiology, Section 7, Steiner, D.F., Freinkel N. (eds.). American Physiological Society, Washington, D. C., Vol. I, p. 611Google Scholar
  3. 3.
    Cameron, D.P., Stauffacher, W., Orci, L., Amherdt, M., Renold, A. E.: Defective immunoreactive insulin secretion in the acomys cahirinus. Diabetes 21, 1060 (1972)PubMedGoogle Scholar
  4. 4.
    Cameron, D.P., Amherdt, M., Orci, L., de Peyer, R., Stauffacher, W.: Biochemical and morphological studies of immunoreactive insulin secretion in spontaneous and acquired obesity and/or hyperglycemia in rodents. Acta Diab. Lat. 9, 89 (1972)Google Scholar
  5. 5.
    Cameron, D. P., Stauffacher, W., Amherdt, M., Orci, L., Renold, A. E.: Kinetics of immunoreactive insulin release in obese hyperglycemic laboratory rodents. Endocrinology 92, 257 (1973)PubMedCrossRefGoogle Scholar
  6. 6.
    Cameron, D.P., Opat, F., Insch, S.: Studies of immunoreactive insulin secretion in NZO mice in vivo. Diabetologia 10, 649 (1974)PubMedCrossRefGoogle Scholar
  7. 7.
    Cerasi, E., Luft, R.: Plasma insulin response to glucose infusion in healthy subjects and-in diabetes mellitus. Acta Endocrin. 55, 278 (1967)Google Scholar
  8. 8.
    Coleman, D. L., Hummely, K. P.: The influence of genetic background on the expression of the obese (ob) gene in the mouse. Diabetologia 9, 287 (1973)PubMedCrossRefGoogle Scholar
  9. 9.
    First Brook Lodge Workshop on Diabetes in Laboratory Animals. Diabetologia 3, 63 (1967)Google Scholar
  10. 10.
    Gutzeit, A., Rabinovitch, A., Studer, P. P., Trueheart, P. A., Cerasi, E., Renold, A.@@E.: Decreased intravenous glucose tolerance and low plasma insulin response in spiny mice (Acomys cahirinus). Diabetologia 10, 667 (1974)Google Scholar
  11. 11.
    Gutzeit, A., Rabinovitch, D., Karakch, C., Stauffacher, W., Renold, A. E., Cerasi, E.: Evidence for decreased sensitivity to glucose of isolated islets from spiny mice (Acomys cahirinus). Diabetologia 10, 661 (1974)PubMedCrossRefGoogle Scholar
  12. 12.
    Hummel, K. P., Coleman, D. L., Lane, P.W.: The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I C57CL/Ks3 and C57BL/6J strains. Biochem. Genetics 7, 1 (1972)CrossRefGoogle Scholar
  13. 13.
    Renold, A. E., Cameron, D. P., Amherdt, M., Stauffacher, W., Marliss, E., Orci, L., Rouiller, C.: Endocrine-metabolic anomalies in rodents with hyperglycemic syndromes of hereditary and/or environmental origin. In: Impact of Insulin on Metabolic Pathways, Shafrir, E. (ed.). London-New York: Akademic Press, 1972, p. 15Google Scholar
  14. 14.
    Malaisse-Lagae, F., Ravazzola, M., Amherdt, M., Gutzeit, A., Stauffacher, W., Malaisse, W. J., Orci, L.: An apparent abnormality of the B-cell microtubular system in spiny mice (Acomys cahirinus). Diabetologia II, 71 (1975)CrossRefGoogle Scholar
  15. 15.
    Second Brook Lodge Workshop on Spontaneous Diabetes in Laboratory Animals. Diabetologia 6, 154 (1970)Google Scholar
  16. 16.
    Stauffacher, W., Orci, L., Amherdt, M., Burr, I. M., Balant, L., Froesch, E. R., Renold, A. E.: Metabolic state, pancreatic insulin content and B-cell morphology of normoglycemic spiny mice (Acomys cahirinus): indications for an impairment of insulin secretion. Diabetologia 6, 330 (1970)PubMedCrossRefGoogle Scholar
  17. 17.
    Stauffacher, W., Orci, L., Cameron, D. P., Burr, I. M., Renold, R.A.: Spontaneous hyperglycemia and/or obesity in laboratory rodents: an example of the possible usefulness of animal disease models with both genetic and environmental components. Rec. Progr. Horm. Res. 27, 41 (1971)PubMedGoogle Scholar
  18. 18.
    Stuhlmann, R. A., Packer, J. T., Doyle, R.E.: Spontaneous diabetes mellitus in Mystromys albicaudatus: repeated values from 620 animals. Diabetes 21, 715 (1972)Google Scholar
  19. 19.
    Stuhlmann, R. A., Srivastava, P.K., Schmidt, G., Vorbeck, M.L., Townsend, J. F.: Characterization of diabetes mellitus in South African Hamster (Mystromys albicaudatus). Diabetologia 10, 685 (1974)CrossRefGoogle Scholar
  20. 20.
    Third Brook Lodge Workshop on Spontaneous Diabetes in Laboratory Animals. Diabetologia 10, 491 (1974)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1976

Authors and Affiliations

  • W. Stauffacher
  • R. Kikkawa
  • M. Amherdt
  • L. Orci

There are no affiliations available

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