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Environmental Factors and Genetic Interactions

  • Chapter
The Genetics of Diabetes Mellitus

Abstract

Diabetes mellitus has long been regarded as a disease, the expression of which depends upon an interaction between hereditary susceptibility and environmental determinants. The relative strength of these two components and the precise nature of their interaction in the individual case has not yet been fully documented, but both genetic susceptibility and the environmental determinants are assumed to be multifactorial and to contribute in varying proportion to the “diabetogenic mix.” Thus, at one extreme there would be almost entirely genetically determined diabetic, presumably with an acute onset early in life. At the other would be the environmental diabetic, exhibiting, in increasing abundance as the years passed by, the cumulation of life’s diabetogenic insults.

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Authors
  1. H. Keen
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  2. R. J. Jarrett
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Editor information

Editors and Affiliations

  1. Medizinische Klinik und Poliklinik der Universität, Humboldtallee, 1, D-3400, Göttingen, Germany

    Werner Creutzfeldt  & Johannes Köbberling  & 

  2. Department of Human Genetics, 1137 E Catherine Street, Ann Arbor, MI, 48104, USA

    James V. Neel

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© 1976 Springer-Verlag Berlin Heidelberg

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Keen, H., Jarrett, R.J. (1976). Environmental Factors and Genetic Interactions. In: Creutzfeldt, W., Köbberling, J., Neel, J.V. (eds) The Genetics of Diabetes Mellitus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66332-1_13

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  • DOI: https://doi.org/10.1007/978-3-642-66332-1_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-07651-3

  • Online ISBN: 978-3-642-66332-1

  • eBook Packages: Springer Book Archive

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