Abstract
In blood, the plasma lipoproteins represent the major vehicle for the transport of triglyceride, cholesterol, both free and esterified, and phospholipid. In addition, these macromolecular complexes are also substrates, activators, and inhibitors for the enzymes involved in lipid metabolism.Knowledge of the molecular organization of the lipid and protein constituents is essential to an understanding of the mechanisms of transport and metabolism of the lipids. For this reason, studies were undertaken designed to determine the mechanism of lipid binding by the plasma apolipoproteins. The purpose of the present report is to summarize these studies and the conclusions which have been drawn from them. For a more general discussion of lipoprotein structure and functiqn, the reader is referred to a recent review (1).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
MORRISETT, J.D., JACKSON, R.L., GOTTO, A.M.: Ann. Rev. Biochem. 44, 183–207 (1975).
MORRISETT, J.D., DAVID, J.S.K., POWNALL, H.J., GOTTO, A.M.: Biochemistry 12, 1290–1299 (1973).
JACKSON, R.L., MORRISETT, J.D., POWNALL, H.J., GOTTO, A.M.: J. biol. Chem. 248, 5218–5224 (1973).
JACKSON, R.L., BAKER, H.N., DAVID, J.S.K., GOTTO, A.M.: Biochem. Biophys. Res. Commun. 49, 1444–1451 (1972).
JACKSON, R.L., MORRISETT, J.D., SPARROW, J.T., SEGREST, J.P., POWNALL, H.J., SMITH, L.C., HOFF, H.F., GOTTO, A.M.: J. biol. Chem. 249, 5314–5320 (1974).
POWNALL, H.J., MORRISETT, J.D., SPARROW, J.T., GOTTO, A.M.: Biochem. Biophys. Res. Commun. 60, 779–786 (1974).
JACKSON, R.L., GOTTO, A.M., LUX, S.E., JOHN, K.M., FLEISCHER, S. J. biol. Chem. 248, 8449–8456 (1973).
SPARROW, J.T., GOTTO, A.M., MORRISETT, J.D.: Proc. nat. Acad. Sci (Wash.) 70, 2124–2128 (1973).
SEGREST, J.P., JACKSON, R.L., MORRISETT, J.D., GOTTO, A.M.: FEBS Letters 38, 247–253 (1974).
GLONEK, T., HENDERSON, T.O., KRUSKI, A.W., SCANU, A.M.: Biochim. biophys. Acta 148, 155–161 (1974).
STOFFEL, W., ZIERENBERG, O., TUNGGAL, B., SCHREIBER, E. Proc. nat. Acad. Sci. (Wash.) 21, 3696–3700 (1974).
ASSMANN, G., HIGHET, R.J., SOKOLOSKI, E.A., BREWER, H.B.: Proc. nat. Acad. Sci. (Wash.) 71., 3701–3705 (1974).
SPARROW, J.T., MORRISETT, J.D., POWNALL, H.J., JACKSON, R.L., GOTTO, A.M.: (In press).
JACKSON, R.L., MORRISETT, J.D., GOTTO, A.M., SEGREST, J.P.: Molec Cell. Biochem. 6., 43–50(1975).
MULLER, K., LAGGNER, P., KRATKY, O., KOSTNER, G., HOLASEK, A., GLATTER, O.: FEBS Letters 40, 213–218 (1974).
ASSMANN, G., BREWER, H.B.: Proc. nat. Acad. Sci. (Wash.) 71, 1534–1538 (1974).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Gotto, A.M., Jackson, R.L., Morrisett, J.D., Pownall, H.J., Sparrow, J.T. (1976). Molecular Association of Lipids and Proteins in the Plasma Lipoproteins: A Review. In: Greten, H. (eds) Lipoprotein Metabolism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66323-9_19
Download citation
DOI: https://doi.org/10.1007/978-3-642-66323-9_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-07635-3
Online ISBN: 978-3-642-66323-9
eBook Packages: Springer Book Archive