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Role of the LDL Receptor in the Regulation of Cholesterol and Lipoprotein Metabolism

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Lipoprotein Metabolism

Abstract

Although it has been well documented that nonhepatic tissues uniformly exhibit low rates of cholesterol synthesis (1, 2), the factors responsible for this suppression and the enzymatic site of regulation have only recently been explored.Studies in cultured human fibroblasts indicate that these peripheral cells have the capacity to synthesize large amounts of cholesterol, but this activity is suppressed when the cells are exposed to whole serum containing low density lipoprotein (LDL) (3, 4). The enzymatic site of this suppression in human fibroblasts has been localized to 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase), the same enzyme that limits the rate of cholesterol synthesis in liver (3, 4).

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Authors
  1. M. S. Brown
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  2. K. Luskey
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  3. H. A. Bohmfalk
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  4. J. Helgeson
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  5. J. L. Goldstein
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Editor information

Editors and Affiliations

  1. Klinisches Institut für Herzinfarktforschung an der Medizinischen-Universitätsklinik, Bergheimer-Str. 58, D-6900, Heidelberg, Federal Republic of Germany

    Heiner Greten

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© 1976 Springer-Verlag Berlin Heidelberg

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Brown, M.S., Luskey, K., Bohmfalk, H.A., Helgeson, J., Goldstein, J.L. (1976). Role of the LDL Receptor in the Regulation of Cholesterol and Lipoprotein Metabolism. In: Greten, H. (eds) Lipoprotein Metabolism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66323-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-66323-9_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-07635-3

  • Online ISBN: 978-3-642-66323-9

  • eBook Packages: Springer Book Archive

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