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Lipoproteins in Animals

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Fettstoffwechsel

Part of the book series: Handbuch der inneren Medizin ((INNEREN 7,volume 7 / 4))

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Abstract

Although the importance of lipoprotein membranes in the economy of the living cell has been recognised for many years, the study of the role of soluble lipoproteins as the agents of lipid transport has only recently begun to attract a comparable degree of attention. This has been mainly directed towards the relatively accessible problem of fat transport in extracellular fluids, for which it is evident that some form of hydrophilic complex is essential. In the restricted context of fatty acid transport, the need can be met by the formation of a simple complex with a protein like albumin but, for the transport of large amounts of such substances as triglyceride or cholesterol, a system capable of operating with a higher ratio of hydrophobic to hydrophilic components is necessary.

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References

  • Abraham, S., Hillyard, L.A., Chaikoff, I.L.: Components of serum and egg yolk lipoproteins: Galactose, mannose, glucosamine and sialic acid. Arch. Biochem. Biophys. 89, 74–78 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Alaupovic, P.: Apolipoproteins and lipoproteins. Atherosclerosis 13, 141–146 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Alaupovic, P.: Operational classification systems of plasma lipoproteins. In: Protides of the Biological Fluids; Proc. 19th. Colloquium, Peeters, H. (ed.), p. 9. Oxford: Pergamon Press 1972.

    Google Scholar 

  • Albers, J.J., Scanu, A.M.: Isoelectric fractionation and characterisation of polypeptides from human serum very low density lipoproteins. Biochim. Biophys. Acta 236, 29–37 (1971).

    PubMed  CAS  Google Scholar 

  • Alexander, C., Day, C.E.: Distribution of serum lipoproteins of selected vertebrates. Comp. Biochem. Physiol. 46 B, 295–312 (1973).

    Google Scholar 

  • Bersot, T.P., Brown, W.V., Levy, R.I., Windmueller, H.G., Fredrickson, D.S., Lequire, V.S.: Further characterisation of the apolipoproteins of rat plasma lipoproteins. Biochemistry 9, 3427–3433 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Blaton, V., Howard, A.N., Gresham, G.A., Van-damme, D., Peeters, H.: Lipid changes in the plasma lipoproteins of baboons given an atherogenic diet. Atherosclerosis 11, 497–507 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Bowden, J.A., Fried, M.: Separation and characterisation of rat plasma lipoproteins by molecular sieve chromatography. Comp. Biochem. Physiol. 32, 391–400 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Bragdon, J.H., Havel, R.J.: In vivo effect of anti-heparin agents on serum lipids and lipoproteins. Amer. J. Physiol. 177, 128–133 (1954).

    PubMed  CAS  Google Scholar 

  • Brown, V.G., Levy, R.I., Fredrickson, D.S.: Further characterisation of apolipoproteins from the human plasma very low density lipoproteins. J. Biol. Chem. 245, 6588–6594 (1970).

    PubMed  CAS  Google Scholar 

  • Burstein, M., Morfin, R.: Précipitation des lipoproteins sériques α et β par des polysaccharides sulfates en présence de chlorure de manganèse. Nouvelle Revue Franç. d’Hématol. 9, 231–244 (1969).

    CAS  Google Scholar 

  • Butkus, A.A., Ehrhart, L.A., Robertson, A.L., Lewis, L.A.: Effects of diets rich in saturated fatty acids with or without added cholesterol on plasma lipids and lipoproteins. Lipids 5, 896–907 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Camejo, G.: Structural studies of rat plasma lipoproteins. Biochemistry 6, 3228–3241 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Camejo, G., Bosch, V., Arreaza, C., Mendez, H.C.: Early changes in plasma lipoprotein structure and biosynthesis in cholesterol-fed rabbits. J. Lipid. Res. 14, 61–68 (1973).

    PubMed  CAS  Google Scholar 

  • Chapman, M.J., Mills, G.L., Taylaur, C.E.: Lipoprotein particles from the Golgi apparatus of guinea-pig liver. Biochem. J. 128, 779–787 (1972).

    PubMed  CAS  Google Scholar 

  • Chapman, M.J., Mills, G.L., Taylaur, C.E.: The effect of a lipid rich diet on the properties and composition of lipoprotein particles from the Golgi apparatus of guinea-pig liver. Biochem. J. 131, 177–185 (1973).

    PubMed  CAS  Google Scholar 

  • Chino, H., Murakami, S., Harashima, K.: Diglyceride-carrying lipoproteins in insect haemolymph. Isolation, purification and properties. Biochim. Biophys. Acta 176, 1–26 (1969).

    PubMed  CAS  Google Scholar 

  • Cox, A.C., Tanford, C.: The molecular weight of porcine plasma high density lipoprotein and its subunits. J. Biol. Chem. 243, 3083–3087 (1968).

    PubMed  CAS  Google Scholar 

  • DePury, G.G., Collins, F.D.: Composition and concentration of lipoproteins in the serum of normal rats and rats deficient in essential fatty acids. Lipids 7, 225–228 (1972).

    Article  CAS  Google Scholar 

  • Dittmer, D.S.: Blood and other Body Fluids. Washington D.C.: Federation of American Societies for Experimental Biology 1961.

    Google Scholar 

  • Eaton, R.P., Kipnis, D.M.: Effects of high carbohydrate diets on lipid and carbohydrate metabolism in the rat. Amer. J. Physiol. 217, 1160–1168 (1969a).

    PubMed  CAS  Google Scholar 

  • Eaton, R.P., Kipnis, D.M.: Radioimmunoassay of betalipoportien-protein of rat serum. J. Clin. Invest. 48, 1387–1396 (1969b).

    Article  PubMed  CAS  Google Scholar 

  • Evans, L., Patton, S., McCarthy, R.D.: Fatty acid composition of the lipid fractions from bovine serum lipoproteins. J. Dairy Sci. 44, 475–482 (1961).

    Article  CAS  Google Scholar 

  • Evans, L.: Comparison of fatty acids from lipid classes of serum lipoproteins and other lipids in bison. J. Dairy Sci. 47, 46–53 (1964).

    Article  CAS  Google Scholar 

  • Ewing, A.M., Freeman, N.K., Lindgren, F.T.: The analysis of human serum lipoprotein distributions. In: Advances in Lipid Research (Paoletti, R., Kritchevsky, D. eds.), Vol. 3, p. 25. New York: Academic Press 1965.

    Google Scholar 

  • Fried, M., Wilcox, H.G., Faloona, G.R., Eoff, S.P., Hoffman, M.S., Zimmerman, D.: The biosynthesis of plasma lipoproteins in higher animals. Comp. Biochem. Physiol. 25, 651–661 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Garlick, D.G., Courtice, F.C.: The composition of the lipoproteins in the plasma of rabbits with hyper-cholesterolaemia or Triton WR-1339-induced hyper-lipaemia. Quart. J. Exper. Physiol. 47, 211–220 (1962).

    CAS  Google Scholar 

  • Glazier, F.W., Tamplin, A.R., Strisower, B., DeLalla, O.F., Gofman, J.W., Dawber, T.R., Phillips, E.: Human serum lipoprotein concentrations. J. Gerontol. 9, 395–403 (1954).

    PubMed  CAS  Google Scholar 

  • Gofman, J.W., Lindgren, F., Elliott, H., Mantz, W., Hewitt, J., Strisower, B., Herring, V.: The role of lipids and lipoproteins in atherosclerosis. Science 111, 166–186 (1950).

    Article  PubMed  CAS  Google Scholar 

  • Gunstone, F.D.: An introduction to the chemistry and biochemistry of fatty acids and their glycerides, 2nd. ed. London: Chapman and Hall 1967.

    Google Scholar 

  • Gustafson, A., Alaupovic, P., Furman, R.H.: Studies of the composition and structure of serum lipoproteins. Separation and characterisation of phospholipid-protein residues obtained by partial delipidization of very low density lipoproteins of human serum. Biochemistry 5, 632–640 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Hamilton, R.L.: Synthesis and secretion of plasma lipoproteins. Adv. Exp. Med. Biol. 26, 7–24 (1972).

    PubMed  CAS  Google Scholar 

  • Hillyard, L.A., White, H.M., Pangburn, S.A.: Characterisation of apolipoproteins in chicken serum and in egg yolk. Biochemistry 11, 511–518 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Howard, A.N., Gresham, G.A., Lindgren, F.T.: Lipoprotein studies on rats fed thrombogenic and atherogenic diets. J. Atherscler. Res. 8, 739–743 (1968).

    Article  CAS  Google Scholar 

  • Jackson, R.L., Baker, H.N., Taunton, O.D., Smith, L.C., Garner, C.W., Gotto, A.M.: A comparison of the major apolipoprotein from pig and human high density lipoproteins. J. Biol. Chem. 248, 2639–2644 (1973).

    PubMed  CAS  Google Scholar 

  • Janado, M., Martin, W.G., Cook, W.H.: Separation and properties of pig-serum lipoproteins. Canad. J. Biochem. 44, 1201–1209 (1966).

    Article  CAS  Google Scholar 

  • Janado, M., Martin, W.G.: Molecular heterogeneity of a pig serum low-density lipoprotein. Canad. J. Biochem. 46, 875–878 (1968).

    CAS  Google Scholar 

  • Kalab, M., Martin, W.G.: Gel filtration of native and modified pig serum lipoproteins. J. Chromat. 35, 230–233 (1968).

    Article  CAS  Google Scholar 

  • Kaminski, M., Mauger, J.-P., Sykiotis, M.: Immunological relationship and chemical similarities between HDL lipoproteins from various mammalian and avian species. In: Protides of the Biological Fluids; Proc. 19th. Colloquium (Peeters, H., ed.), p. 179. Oxford: Pergamon Press 1972.

    Google Scholar 

  • Kirkeby, K.: Total lipids and lipoproteins in animal species. Scandinav. J. Clin. Lab. Invest. 18, 437–442 (1966).

    Article  CAS  Google Scholar 

  • Koga, S., Horwitz, D.L., Scanu, A.M.: Isolation and properties of lipoproteins from normal rat serum. J. Lipid Res. 10, 577–588 (1969).

    PubMed  CAS  Google Scholar 

  • Koga, S., Bolis, L., Scanu, A.M.: Isolation and characterisation of subunit polypeptides from apoproteins of rat serum lipoprotein. Biochim. Biophys. Acta 236, 416–430 (1971).

    PubMed  CAS  Google Scholar 

  • Langer, T., Strober, W., Levy, R.I.: The metabolism of low density lipoprotein in familial Type II hyperli-poproteinaemia. J. Clin. Invest. 51, 1528–1536 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Lasser, N.L., Roheim, P.S., Edelstein, D., Eder, H.A.: Serum lipoproteins of normal and cholesterol-fed rats. J. Lipid Res. 14, 1–8 (1973).

    PubMed  CAS  Google Scholar 

  • Lauter, C.J., Brown, E.A.B., Trams, E.G.: Composition of plasma lipoproteins of the spiny dogfish Squalus acanthias. Comp. Biochem. Physiol. 24, 243–247 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Leat, W.M.F., Baker, J.: Distribution of fatty acids in the plasma lipids of herbivores grazing pasture: a species comparison. Comp. Biochem. Physiol. 36, 153–161 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Lee, R.F., Puppione, D.L.: Serum lipoproteins of the Pacific sardine (Sardinops caerulea Girard). Biochim. Biophys. Acta 270, 272–278 (1972).

    PubMed  CAS  Google Scholar 

  • Levy, R.I., Bilheimer, D.W., Eisenberg, S.: Structure and metabolism of chylomicrons and very low density lipoproteins (VLDL). In: Biochemical Society Symposium No. 33: Plasma Lipoproteins (Smellie, R.M.S., ed.), p. 3. London: Academic Press 1971.

    Google Scholar 

  • Levy, R.S., Lynch, A.C., McGee, E.D., Mehl, J.W.: Amino-acid composition of the proteins from chylomicrons and human serum lipoproteins. J. Lipid Res. 8, 463–472 (1967).

    PubMed  CAS  Google Scholar 

  • Levy, R.S., Martin, M.V., van Remortel, H., Harbaugh, J.F.: Comparison of the apoprotein from serum high density lipoprotein (HDL) from man, bull, and chicken by partial sequencing. Fed. Proc. 31, A880 (1972).

    Google Scholar 

  • Lewis, L.A., Green, A.A., Page, I.H.: Ultracentrifuge lipoprotein patterns of serum of normal, hypertensive and hypothyroid animals. Amer. J. Physiol. 171, 391–400 (1952).

    PubMed  CAS  Google Scholar 

  • Lindgren, F.T., Nichols, A.V.: Structure and function of human serum lipoproteins. In: The Plasma Proteins (Putnam, F.W., ed.), Vol. 2, p. 1. New York: Academic Press 1960.

    Google Scholar 

  • Long, C.: Biochemists Handbook, London: Spon 1961.

    Google Scholar 

  • Marsh, J.B.: Biosynthesis of serum lipoproteins. In: Structural and Functional Aspects of Lipoproteins in Living Systems (Tria, E., Scanu, A.M., eds.), p. 447. New York: Academic Press 1969.

    Google Scholar 

  • Marsh, J.B., Fritz, R.: The carbohydrate components of rat serum lipoproteins. Proc. Soc. Exp. Biol. Med. 133, 9–10 (1970).

    PubMed  CAS  Google Scholar 

  • Marshall, W.E., Kummerow, F.A.: The carbohydrate constituents of human serum β-lipoprotein: Galactose, Mannose, Glucosamine and Sialic acid. Arch. Biochem. Biophys. 98, 271–273 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Martin, W.G., Takats, I.: Physicochemical properties of the very low density lipoprotein of porcine serum. Biochim. Biophys. Acta 187, 328–334 (1969).

    PubMed  CAS  Google Scholar 

  • Mills, G.L., Wilkinson, P.A.: The distribution of β-lipoproteins in human plasma. Clin. Chim. Acta 8, 701–709 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Mills, G.L., Taylaur, C.E.: The distribution and composition of serum lipoproteins in eighteen animals. Comp. Biochem. Physiol. 40 B, 489–501 (1971).

    Google Scholar 

  • Mills, G.L., Chapman, M.J., McTaggart, F.: Some effects of diet on guinea pig serum lipoproteins. Biochim. Biophys. Acta 260, 401–412 (1972a).

    PubMed  CAS  Google Scholar 

  • Mills, G.L., Chong, Y.H., Taylaur, C.E.: Variation in composition of serum low density lipoproteins in healthy men. Clin. Chim. Acta 42, 273–283 (1972b).

    Article  CAS  Google Scholar 

  • Mills, G.L., McTaggart, F.: Characterisation of experimental Type II hyperlipoproteinaemia in guinea pigs. In: Proc. 3rd. Int. Symp. on Atherosclerosis (Jones, R.J., ed.). Heidelberg: Springer 1973a. In press.

    Google Scholar 

  • Mills, G.L., Taylaur, C.E.: The distribution and composition of serum lipoproteins in the coelacanth (Latimeria). Comp. Biochem. Physiol. 44 B, 1235–1341 (1973 b).

    Google Scholar 

  • Morris, M.D., Fitch, C.D.: Spontaneous hyperbetali-poproteinaemia in the Rhesus monkey. Biochem. Med. 2, 209–215 (1968).

    Article  CAS  Google Scholar 

  • Narayan, K.A.: Disc electrophoresis of human and animal serum lipoproteins. Lipids 2, 282–284 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Narayan, K.A.: Lowered serum concentration of high density lipoproteins in cholesterol fed rats. Atherosclerosis 13, 205–215 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Nelson, G.J.: Lipid composition of whole plasma of Hampshire sheep. Comp. Biochem. Physiol. 30, 715–721 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Ockner, R.K., Jones, A.L.: An electron microscopic and functional study of very low density lipoproteins in intestinal lymph. J. Lipid Res. 11, 284–292 (1970).

    PubMed  CAS  Google Scholar 

  • Okey, R., Greaves, V.: Anaemia caused by feeding cholesterol to guinea pigs. J. Biol. Chem. 129, 111–123 (1939).

    CAS  Google Scholar 

  • Puppione, D.L.,Forte, G.M., Nichols, A.V., Strisower, E.H.: Partial characterisation of serum lipoproteins in the density interval 1.04–1.06 g/ml. Biochim. Biophys. Acta 202, 392–395 (1970a).

    PubMed  CAS  Google Scholar 

  • Puppione, D.L., Nichols, A.V.: Chracterisation of the chemical and physical properties of the serum lipoproteins of certain marine mammals. Physiol. Chem. Physics 2, 49–58 (1970 b).

    CAS  Google Scholar 

  • Puppione, D.L., Forte, G.M., Nichols, A.V.: Serum lipoproteins of killer whales. Comp. Biochem. Physiol. 39 B, 673–681 (1971a).

    Google Scholar 

  • Puppione, D.L., Sardet, C., Yamanaka, W., Ostwald, R., Nichols, A.V.: Plasma lipoproteins of cholesterol-fed guinea pigs. Biochem. Biophys. Acta 231, 295–301 (1971b).

    PubMed  CAS  Google Scholar 

  • Reiser, R., Clark, D.A., Sorrels, M.F., Gibson, B.S., Williams, M.C., Wilson, F.H.: Tissue cholesterol transport as modified by diet cholesterol and the nature of diet fat. J. Atheroscler. Res. 6, 565–579 (1966).

    Article  CAS  Google Scholar 

  • Rubenstein, B., Rubinstein, D.: Interrelationship between rat serum very low density and high density lipoproteins. J. Lipid Res. 13, 317–324 (1972).

    PubMed  CAS  Google Scholar 

  • Sardet, C., Hansma, H., Ostwald, R.: Characterisation of guinea pig plasma lipoproteins: the appearance of new lipoproteins in response to dietary cholesterol. J. Lipid Res. 13, 624–639 (1972).

    PubMed  CAS  Google Scholar 

  • Scanu, A.: Forms of human serum high density lipoprotein protein. J. Lipid Res. 7, 295–306 (1966).

    PubMed  CAS  Google Scholar 

  • Scheide, O.A.: Lipoproteins of the fowl: serum, egg and intracellular. In: Progress in the Chemistry of Fats and other Lipids (Holman, R.T., Lundberg, W.O., Malkin, T., eds.), Vol. 6, p. 251. Oxford: Pergamon Press 1963.

    Google Scholar 

  • Schultze, H.E.: Ãœber Glykoproteine. Dt. med. Wschr. 83, 1742–1752 (1958).

    Article  CAS  Google Scholar 

  • Schumaker, V.N.: Cholesterolaemic rabbit lipoproteins: Serum lipoproteins of the cholesterolaemic rabbit. Amer. J. Physiol. 184, 35–42 (1956).

    PubMed  CAS  Google Scholar 

  • Schumaker, V.N., Adams, G.H.: Circulating lipoproteins. Ann. Rev. Biochem. 38, 113–136 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Shiff, T.S., Roheim, P.S., Eder, H.A.: Effects of high sucrose diets and 4-aminopyrazolopyrimidine on serum lipids and lipoproteins in the rat. J. Lipid Res. 12, 596–603 (1971).

    PubMed  CAS  Google Scholar 

  • Shore, V.G., Shore, B.: The apolipoproteins: Their structure and functional roles in human serum lipoproteins. In: Blood lipids and lipoproteins: Quantitation, composition and metabolism (Nelson, G., ed.), p. 789. New York: Wiley-Interscience 1972.

    Google Scholar 

  • Skipski, V.P., Barclay, M., Barclay, R.L., Fetzer, V.A., Good, J.J., Archibald, F.M.: Lipid composition of human serum lipoproteins. Biochem. J. 104, 340–352 (1967).

    PubMed  CAS  Google Scholar 

  • Slack, J., Mills, G.L.: Anomalous low density lipoproteins in familial hyperbetalipoproteinaemia. Clin. Chim. Acta 29, 15–25 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Solyom, A., Bradford, R.H., Furman, R.H.: Apolipoproteins and lipid distribution in canine serum lipoproteins. Biochim. Biophys. Acta 229, 471–483 (1971).

    PubMed  CAS  Google Scholar 

  • Spritz, N., Mishkel, M.A.: Effect of dietary fats on plasma lipids and lipoproteins: an hypothesis for the lipid-lowering effect of unsaturated fatty acids. J. Clin. Invest. 48, 78–86 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Switzer, S., Eder, H.A.: Transport of lysolecithin by albumin in human and rat plasma. J. Lipid Res. 6, 506–511 (1965).

    PubMed  CAS  Google Scholar 

  • Thomas, K.K., Gilbert, L.I.: Isolation and characterisation of the haemolymph lipoproteins of the American silkmoth, Hyalophora cecropia. Arch. Biochem. Biophys. 127, 512–521 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Trams, E.G., Brown, E.A., Lauter, C.J.: Lipoprotein synthesis 1. Rat plasma lipoprotein composition and synthesis from radioactive precursors. Lipids 1, 309–315 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Walton, K.W., Darke, S.J.: Immunological characteristics of human low-density lipoproteins and their relation to lipoproteins of other species. In: Protides of the Biological Fluids; Proc. 10th. Colloquium (Peeters, H., ed.), p. 146. Amsterdam: Elsevier Publishing Co. 1963.

    Google Scholar 

  • Welch, V.A., Stead, D.: Private communication 1973.

    Google Scholar 

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Mills, G.L. (1976). Lipoproteins in Animals. In: Assmann, G., et al. Fettstoffwechsel. Handbuch der inneren Medizin, vol 7 / 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66302-4_5

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