Abstract
The prognosis and final outcome in patients with severe head injuries is closely related, among other factors, to the level of increased intracranial pressure (ICP) caused by cerebral edema as well as to the severity of CSF lactacidosis. There exists evidence that a clearance of substances which accumulate in edematous tissue, i.e. proteins and lactate, without rising the ICP exerts a beneficial effect in such cases. Previous studies by other groups (4, 5) using a similar experimental technique but with small amounts of perfusion-volume were concerned with the influence of various concentrations of bicarbonate of the perfusion medium on the regulation mechanisms of cerebral blood flow (CBF). The present study was carried out to investigate the effect of a ventriculo-cisternal perfusion with a flow volume leading to a ten to twelve timefold exchange of the intraventricular cerebro-spinal fluid (CSF) volume on the normal cerebral blood flow.
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© 1975 Springer-Verlag Berlin · Heidelberg
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Schubert, R., Fenske, A., Grote, J., Reulen, H.J. (1975). The Influence of Ventricular Perfusion on Normal Brain. In: Penzholz, H., Brock, M., Hamer, J. (eds) Brain Hypoxia. Advances in Neurosurgery, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66239-3_7
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DOI: https://doi.org/10.1007/978-3-642-66239-3_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-07466-3
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