Brain Hypoxia pp 442-449 | Cite as

Gelastic Epilepsy in Tumors of the Hypothalamic Region

  • G. Pendl
Part of the Advances in Neurosurgery book series (NEURO, volume 3)


Laughter is a rare ictal phenomenon. One must differentiate uncontrollable laughter as a result of several other pathological causes from those rare types of epileptic seizures, which were named gelastic epilepsy by DALY and MULDER (3). The criteria used by GASCON and LOMBROSO (7) and by REY-PIAS (19) for a true case of laughter as an epileptic symptom may also be applied to two cases which were encountered in the last two years at our Neurosurgery Service: They include sterotype recurrence; absence of external precipitants; concomitance with other manifestations generally accepted as epileptic, such as tonic or clonic movements, loss of consciousness, automatisms; presence of interictal and, where it can be recorded, ictal epileptiform discharges on EEG tracings; and absence of neurological signs characteristic of conditions in which pathological laughter may occur, i.e., bilateral cortico-bulbar lesions, multiple sclerosis, amyotrophic lateral sclerosis, lacunar states, bilateral frontal lobe disease, and various emotional states (2, 11).


Amyotrophic Lateral Sclerosis Limbic System Seizure Frequency Precocious Puberty Basal Cistern 
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  1. 1.
    Bierich, J.R., Blunck, W., Schönberg, D.: Frühreife bei cerebralorganischen Erkrankungen. Mschr. Kinderheilk. 115, 509–516 (1965).Google Scholar
  2. 2.
    Chen, R., Forster, F.M.: Cursive epilepsy and gelastic epilepsy. Neurology, 23, 1019–1029 (1973).PubMedGoogle Scholar
  3. 3.
    Daly, D., Mulder, D.: Gelastic epilepsy. Neurology, 7, 189–192 (1957).PubMedGoogle Scholar
  4. 4.
    Dott, N.M.: Surgical aspects of the hypothalamus. In: The hypothalamus, morpholocical, functional, clinical and surgical aspects (eds. W.E. Clark, J. Beattie, G. Le Gros, G. Riddoch, N.M. Dott), pp. 179. Edinburgh: Oliver and Boyd 1938.Google Scholar
  5. 5.
    Driggs, M., Spatz, H.: Pubertas praecox bei einer hyperplastischen Mißbildung des Tuber cinereum. Arch. path. Anat. 305, 567–592 (1939).CrossRefGoogle Scholar
  6. 6.
    Druckman, R., Chao, D.: Laughter in epilepsy. Neurology 7, 26–36 (1957).PubMedGoogle Scholar
  7. 7.
    Gascon, G.G., Lombroso, C.T.: Epileptic (gelastic) laughter. Epilepsia 12, 63–76 (1971).PubMedCrossRefGoogle Scholar
  8. 8.
    Gumpert, J., Hansotia, P., Upton, P.: Gelastic epilepsy. J. Neurol. Neurosurg. Psychiat. 33, 479–483 (1970).PubMedCrossRefGoogle Scholar
  9. 9.
    Heppner, F.: Eingriffe am limbischen System. Zbl. Neurochir. 17, 140–151 (1957).Google Scholar
  10. 10.
    Ironside, R.: Disorders of laughter due to brain lesions. Brain 79, 589–609 (1956).PubMedCrossRefGoogle Scholar
  11. 11.
    Lehtinen, L., Kivalo, A.: Laughter epilepsy. Acta neurol. Scand. 41, 255–261 (1965).PubMedCrossRefGoogle Scholar
  12. 12.
    List, C.F., Dowman, C.E., Bagchi, B.K., Bebin, J.: Posterior hypothalamic hamartomas and gangliogliomas causing precocious puberty. Neurology 8, 164–174 (1958).PubMedGoogle Scholar
  13. 13.
    Loiseau, P., Cohadon, F., Cohandon, S.: Gelastic epilepsy. A review and report of five cases. Epilepsia 12, 313–323 (1971).Google Scholar
  14. 14.
    Maclean, P.D.: The limbic system (‘visceral brain’) and emotional behaviour. Arch. Neurol. Psychiat. 73, 130–134 (1955).Google Scholar
  15. 15.
    Maclean, P.D.: The limbic galaxy. In: Limbisches System und Epilepsie (ed. F. Heppner), p. 52. Bern: Hans Huber 1973.Google Scholar
  16. 16.
    Martin, J.P.: Fits of laugther (shame mirth) in organic brain disease. Brain 73, 453–464 (1950).PubMedCrossRefGoogle Scholar
  17. 17.
    Matson, D.D.: Neurosurgery of infancy and childhood. Springfield/ Ill.: Charles C. Thomas 1969.Google Scholar
  18. 18.
    Money, J., Hosta, G.: Laughing seizures with sexual precocity. Report of two cases. John Hopkins Med. J. 120, 326–336 (1967).Google Scholar
  19. 19.
    Rey-Pias, J.M.: Gelastic epilepsy (laughing seizures). Schweizer Arch. Neurol. Neurochir. Psychiat. 111, 29–35 (1972).Google Scholar
  20. 20.
    Roberson, C., Till, K.: Hypothalamic gliomas in children. J. Neurol. Neurosurg. Psychiat. 37, 1047–1052 (1974).CrossRefGoogle Scholar
  21. 21.
    Smythies, J.R.: Brain mechanisms and behaviour. Oxford: Blackwell 1970.Google Scholar
  22. 22.
    Stein, B.M., Fraser, R.A.R., Tenner, M.S.: Tumours of the third ventricle in children. J. Neurol. Neurosurg. Psychiat. 35, 776–788 (1972).PubMedCrossRefGoogle Scholar
  23. 23.
    Stutte, H.: Zwangsaffekte und paroxysmale Lach-und Weinausbrüche als Epilepsie-Symptom. Nervenarzt 34, 290–295 (1963).PubMedGoogle Scholar
  24. 24.
    Swash, M.: Released involuntary laughter after temporal lobe infarction. J. Neurol. Neurosurg. Psychiat. 35, 108–113 (1972).PubMedCrossRefGoogle Scholar
  25. 25.
    Weil, A., Nosik, W.A., Demmy, N.: Electroencephalographic correlation of laughing fits. Amer. J. med. Sciences 235, 301–308 (1958).CrossRefGoogle Scholar

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© Springer-Verlag Berlin · Heidelberg 1975

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  • G. Pendl

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