Abstract
A profitable approach to an understanding of tumor biology would be a study of how tumors reorganize their local environment to facilitate tumor growth. For example, Reich has suggested that proteases secreted by malignant cells may increase the permeability of neighboring vessels to allow increased uptake of proteins and amino acids by the tumor (20). Gullino has shown that, while the collagen within a tumor is produced by the host, the content of collagen is controlled by the tumor cells (15).
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Folkman, J., Klagsbrun, M. (1975). Tumor Angiogenesis: Effect on Tumor Growth and Immunity. In: Gottlieb, A.A., Plescia, O.J., Bishop, D.H.L. (eds) Fundamental Aspects of Neoplasia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66112-9_31
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DOI: https://doi.org/10.1007/978-3-642-66112-9_31
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