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Current Topics in Microbiology and Immunology pp 51–100Cite as

Temperature-Sensitive Mutants of Herpesviruses

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 70))

Abstract

The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type.

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References

  • AlbRecht, T., Rapp, F.: Malignant transformation of hamster embryo fibroblasts following exposure to ultraviolet-irradiated human cytomegalovirus. Virology 55, 53–61 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Aron, G. M., Schaffer, P.A., Benyesh-Melnick, M.: DNA polymerase activity in DNA-negative temperature-sensitive mutants of herpes simplex virus. Abstracts Ann. Meet. Amer. Soc. Microbiol. V 42, 201 (1973a)

    Google Scholar 

  • Aron, G. M., Schaffer, P.A., Courtney, R. J., Benyesh-Melnick, M., Kit, S.: Thymidine kinase activity of herpes simplex virus temperature-sensitive mutants. Intervirology 1, 96–109 (1973b)

    Article  PubMed  CAS  Google Scholar 

  • Atchison, R. W.: The role of herpes virus in adenovirus-associated virus replication in vitro. Virology 42, 155–162 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Aurelian, L.: Virions and antigens of herpes virus type-2 in cervical carcinoma. Cancer Res. 33, 1539–1547 (1973)

    PubMed  CAS  Google Scholar 

  • Bachenheimer, S. L., Kieff, E. D., Lee, L. F., Roizman, B.: Comparative studies of DNAs of Marek’s disease and herpes simplex viruses. In: Oncogenesis and herpesviruses, Biggs, P.M., de-The, G., Payne, L.N. (eds.). Lyon: Int. Agency Res. Cancer 1972

    Google Scholar 

  • Becker, Y., Dym, H., Sarov, I.: Herpes simplex virus DNA. Virology 36, 184–192 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Ben-Porat, T., Shimono, H., Kaplan, A.: Synthesis of proteins in cells infected with herpesvirus. II. Flow of structural viral proteins from cytoplasm to nucleus. Virology 37, 56–61 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Biswal, N., Murray, B. K., Benyesh-Melnick, M.: Ribonucleotides in newly synthesized DNA of herpes simplex virus. Virology 61, 87–99 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Bone, D. R., Benyesh-Melnick, M., Courtney, R. J.: A temperature-sensitive mutant of herpes simplex virus defective in the synthesis of the major capsid polypeptide. Abstracts Ann. Meet. Amer. Soc. Microbiol. V 320, 247 (1973)

    Google Scholar 

  • Bone, D. R., Courtney, R. J.: A temperature-sensitive mutant of herpes simplex virus type 1 defective in the synthesis of the major capsid polypeptide. J. gen. Virol. 24, 17–27 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Boucher, W., Melnick, J. L., Mayor, H. D.: Nonencapsidated infectious DNA of adenosatellite virus cells coinfected with herpesvirus. Science 173, 1243–1245 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Brown, S. M., Ritchie, D. A., Subak-Sharpe, J.H.: Genetic studies with herpes simplex virus type 1. The isolation of temperature-sensitive mutants, their arrangement into complementation groups and recombination analysis leading to a linkage map. J. gen. Virol. 18, 329–346 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Burge, B. W., Pfefferkorn, E. R.: Isolation and characterization of conditional-lethal mutants of Sindbis virus. Virology 30, 204–213 (1966a)

    Article  PubMed  CAS  Google Scholar 

  • Burge, B. W., Pfefferkorn, E. R.: Complementation between temperature-sensitive mutants of Sindbis virus. Virology 30, 214–223 (1966b)

    Article  PubMed  CAS  Google Scholar 

  • Cameron, K. R.: Ultraviolet irradiation of herpes simplex virus. Action spectrum for the survival of infectivity in relation to the small-plaque effect. J. gen. Virol. 18, 51–54 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Cerda-Olmedo, E., Honawalt, P. C., Guerola, N.: Mutagenesis of the replication point by nitrosoguanidine: Map and pattern of replication of the Escherichia coli chromosome. J. molec. Biol. 33, 705–719 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Chou, J. Y., Martin, R. C.: Complementation analysis of simian virus 40 mutants. J.Virol. 13, 1101–1109 (1974)

    PubMed  CAS  Google Scholar 

  • Collard, W., Thornton, W. H., Green, M.: Cells transformed by human herpesvirus type 2 transcribe virus-specific RNA sequences shared by herpesvirus types 1 and 2. Nature (Lond.) New Biol. 243, 264 (1973)

    CAS  Google Scholar 

  • Cooper, P.: The mutation of poliovirus by 5-fluorouracil. Virology 22, 186–192 (1964)

    Article  PubMed  CAS  Google Scholar 

  • Cooper, P. D.: The genetic analysis of poliovirus. In: The biochemistry of viruses, Levy, H. B. (ed.). New York: Dekker 1969

    Google Scholar 

  • Courtney, R. J., Benyesh-Melnick, M.: Isolation and characterization of a large molecular weight polypeptide of herpes simplex virus type 1. Virology 62, 539–551 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Danna, K. J., Sack, G. H., JR., Nathans, D.: A cleavage map of the SV40 genome. J. molec. Biol. 78, 363–376 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Drake, J.W.: The molecular basis of mutation. San Francisco-London-Cambridge-Amsterdam: Holden-Day 1970

    Google Scholar 

  • Drake, S., Schaffer, P. A., Esparza, J., Mayor, H. D.: Complementation of adeno-associated satellite viral antigens and infectious DNA by temperature-sensitive mutants of herpes simplex virus. Virology 60, 230–236 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Duff, R., Rapp, F.: Oncogenic transformation of hamster cells after exposure to herpes simplex virus type 2. Nature (Lond.) New Biol. 233, 48 (1971)

    Article  CAS  Google Scholar 

  • Duff, R., Rapp, F.: Oncogenic transformation of hamster embryo cells after exposure to inactivated herpes simplex virus type 1. J. Virol. 12, 209–217 (1973)

    PubMed  CAS  Google Scholar 

  • Epstein, R. H., Bolle, A., Steinberg, C. M., Kellenberger, E., Edgar, R. S., Susman, M., Denhardt, G. H., Lielausis, A.: Physiological studies of conditional lethal mutants of bacteriophage T4D. Cold Spr. Harb. Symp. quant. Biol. 28, 375–394 (1963)

    CAS  Google Scholar 

  • Erikson, R. L., Szybalski, W.: The Cs2S04 equilibrium density gradient and its application for the study of T-even phage DNA: Glucosylation and replication. Virology 22, 111–124 (1964)

    Article  CAS  Google Scholar 

  • Esparza, J.: Studies with temperature-sensitive mutants of herpes simplex virus type 2. Ph. D. Dissertation, Baylor College of Medicine, 1974

    Google Scholar 

  • Esparza, J., Purifoy, D. J. M., Schaffer, P.A., Benyesh-Melnick, M.: Isolation, complementation and preliminary phenotypic characterization of temperature-sensitive mutants of herpes simplex virus type 2. Virology 57, 554–565 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Farley, C. A., Banfield, W. G., Kasnic, G., Foster, W. S.: Oyster herpes-type virus. Science 178, 759–760 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Fenner, F.: Conditional lethal mutants of animal viruses. Curr. Topics Microbiol. Immunol. 48, 1–28 (1969)

    CAS  Google Scholar 

  • Fenner, F.: The genetics of animal viruses. Ann. Rev. Microbiol. 24, 297–334 (1970)

    Article  CAS  Google Scholar 

  • Fields, B. N., Joklik, W. K.: Isolation and preliminary genetic and biochemical characterization of temperature-sensitive mutants of reovirus. Virology 37, 335–342 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Figueroa, M. E., Rawls, W. E.: Biological markers for differentiation of herpesvirus strains of oral and genital origin. J. gen. Virol. 4, 259–267 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Fitch, W. M.: Does the fixation of neutral mutations form a significant part of observed evolution in proteins? In: Evolution of genetic systems, Smith, H.H. (ed.). New York: Gordon & Breach 1972

    Google Scholar 

  • Freese, E.: Molecular mechanism of mutations, In: Molecular genetics, Taylor, J. M. (ed.). New York: Academic Press 1963

    Google Scholar 

  • Frenkel, N., Roizman, B.: Separation of the herpesvirus deoxyribonucleic acid duplex into unique fragments and intact strand on sedimentation in alkaline gradients. J. Virol. 10, 565–572 (1972)

    PubMed  CAS  Google Scholar 

  • Furlong, D., Swift, H., Roizman, B.: Arrangement of herpesvirus deoxyribonucleic acid in the core. J. Virol. 10, 1071–1074 (1972)

    PubMed  CAS  Google Scholar 

  • Ghendon, Y. Z.: Conditional lethal mutants of animal viruses. Progr. med. Virol. 14, 68–122 (1972)

    Google Scholar 

  • Gordin, M., Olshevsky, U., Rosenkranz, H. S., Becker, Y.: Studies on herpes simplex virus DNA: Denaturation properties. Virology 55, 280–284 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Graham, B. J., Ludwig, H., Bronson, D. L., Benyesh-Melnick, M., Biswal, N.: Physicochemical properties of the DNA of herpes viruses. Biochim. biophys. Acta (Amst.) 259, 13–23 (1972)

    CAS  Google Scholar 

  • Graham, F. L., Veldhuisen, G., Wilkie, N. M.: Infectious herpesvirus DNA. Nature (Lond.) New Biol. 245, 265–266 (1973)

    CAS  Google Scholar 

  • Halliburton, I. W., Timbury, M. C.: Characterization of temperature-sensitive mutants of herpes simplex virus type 2. Growth and DNA synthesis. Virology 54, 60–68 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Hay, J., Perera, P. A. J., Morrison, J. M., Gentry, G. A., Subak-Sharpe, J. H.: In: Strategy of the viral genome, Wolstenholme, G. G. W., O’Connor, M. (eds.). Edinburgh: Churchill Livingstone. Ciba Foundation Symposium 1971

    Google Scholar 

  • Hayes, W.: The genetics of bacteria and their viruses. Studies in basic genetics and molecular biology, 2nd ed. New York: John Wiley 1968

    Google Scholar 

  • Hirsch, I., Vonka, V.: Ribonucleotides linked to DNA of herpes simplex virus type 1. J.Virol. 13, 1162–1168 (1974)

    PubMed  CAS  Google Scholar 

  • Honess, R. W., Roizman, B.: Proteins specified by herpes simplex virus. XI. Identification and relative molar rates of synthesis of structural and nonstructural herpes virus polypeptides in the infected cell. J. Virol. 12, 1347–1365 (1973)

    PubMed  CAS  Google Scholar 

  • Huang, E. S., Pagano, J. S.: Human cytomegalovirus. II. Lack of relatedness to DNA of herpes simplex I and II, Epstein-Barr virus, and nonhuman strains of cytomegalovirus. J.Virol. 13, 642–645 (1974)

    PubMed  CAS  Google Scholar 

  • Hunt, R. D., Melendez, L. V.: Herpes virus infections of non-human primates: A review. Lab. Animal Care 19, 221–234 (1969)

    CAS  Google Scholar 

  • Huy, V. D., Stäber, H., Waschke, K., Rosenthal, H. A.: Isolation and complementation of ts mutants of Pseudorabies virus. In: International virology, Melnick, J. L. (ed.), vol. 2. Basel: Karger 1972

    Google Scholar 

  • Kazama, F. Y., Schornstein, K. L.: Herpes-type virus particles associated with a fungus. Science 177, 696–697 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Kieff, E., Hoyer, B., Bachenheimer, S., Roizman, B.: Genetic relatedness of type 1 and type 2 herpes simplex viruses. J. Virol. 9, 738–745 (1972)

    PubMed  CAS  Google Scholar 

  • Kimura, S., Esparza, J., Benyesh-Melnick, M., Schaffer, P. A.: Enhanced replication of temperature-sensitive mutants of herpes simplex virus type 2 (HSV-2) at the nonpermissive temperature in cells transformed by HSV-2. Intervirology, 3, 162–169 (1974b)

    Article  PubMed  CAS  Google Scholar 

  • Kimura, S., Schaffer, P. A., Benyesh-Melnick, M.: Replication of ts mutants of herpes simplex virus type 2 (HSV-2) at the nonpermissive temperature in cells transformed by HSV-2. Abstracts Amer. Assoc. Cancer Res., p. 58 (1974a)

    Google Scholar 

  • Kirkwood, J., Geering, G., Old, L. J.: Demonstration of group and type-specific antigens of herpesviruses. In: Oncogenesis and herpesviruses, Biggs, P. M., de-The, G., Payne, L. N. (eds.). Lyon: Int. Agency Res. Cancer 1972

    Google Scholar 

  • Kit, S., Dubbs, D. R.: Acquisition of thymidine kinase activity by herpes simplex infected mouse fibroblast cells. Biochem. biophys. Res. Commun. 11, 55–59 (1963)

    Article  PubMed  CAS  Google Scholar 

  • Kit, S., Dubbs, D. R.: Enzyme induction by viruses. In: Monographs in virology, Melnick, J. L. (ed.), vol. 2. Basel-New York: Karger 1969

    Google Scholar 

  • Kit, S., Piekarski, L. J., Dubbs, D. R.: DNA polymerase induced by simian virus 40. J. gen. Virol. 1, 163–173 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Klein, G.: Herpesviruses and oncogenesis. Proc. nat. Acad. Sci. (Wash.) 69, 1056–1064 (1972)

    Article  CAS  Google Scholar 

  • Koment, R. W., Rapp, F.: Conditional lethal mutants of herpes simplex virus type 2. Abstracts Ann. Meet. Amer. Soc. Microbiol. V 200, 234 (1974)

    Google Scholar 

  • Lai, C.-J., Nathans, D.: Mapping temperature-sensitive mutants of simian virus 40: Rescue of mutants by fragments of viral DNA. Virology 60, 466–475 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Lanni, Y. T., Lanni, F., Tevethia, M. J.: Bacteriophage T5 chromosome fractionation: Genetic specificity of a DNA fragment. Science 152, 208–210 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Low, M., Hay, J., Keir, H. M.: DNA of herpes simplex virus is not a substrate for methylation in vivo. J. molec. Biol. 46, 205–207 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Low, M., Mechie, M. I., Hay, J.: Methylation of pseudorabies-virus deoxyribonucleic acid. Biochem. J. 124, 63P (1971)

    CAS  Google Scholar 

  • Ludwig, H. O., Biswal, N., Benyesh-Melnick, M.: Studies on the relatedness of herpesviruses through DNA-DNA hybridization. Virology 49, 95–101 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Macnab, J. C. M.: Transformation of rat embryo cells by temperature sensitive mutants of herpes simplex virus. J. gen. Virol. 24, 143–153 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Manservigi, R.: Method for isolation and selection of temperature-sensitive mutants of herpes simplex virus. Appl. Microbiol. 27, 1034–1040 (1974)

    PubMed  CAS  Google Scholar 

  • Mayor, H. D.: Satellite viruses. Meth. Cancer Res. 8, 203–236 (1973)

    CAS  Google Scholar 

  • Munyon, W., Buchsbaum, R., Paoletti, E., Mann, J., Kraiselburd, E., Davis, D.: Electrophoresis of thymidine kinase activity synthesized by cells transformed by herpes simplex virus. Virology 49, 683–689 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Nahmias, A. J., Chang, G. C. H., Fritz, M. E.: Herpesviruses as infectious and oncogenic agents in man and other vertebrates. In: Membranes and viruses in immunopathology, Day, S. B., Good, R. A. (eds.). New York: Academic Press 1972

    Google Scholar 

  • Nahmias, A. J., Dowdle, W. R.: Antigenic and biologic differences in herpesvirus hominis. Progr. med. Virol. 10, 110–159 (1968)

    CAS  Google Scholar 

  • Nahmias, A. J., Josey, W. E., Naib, Z. M., Luce, C. F., Guest, B. A.: Antibodies to herpesvirus hominis types 1 and 2 in humans. II. Women with cervical cancer. Amer. J. Epidemiol. 91, 547–552 (1970)

    CAS  Google Scholar 

  • Nazerian, K.: DNA configuration in the core of Marek’s disease virus. J. Virol. 13, 1148–1150 (1974)

    PubMed  CAS  Google Scholar 

  • Nn, S.: Electron microscopic observations on FL cells infected with herpes simplex virus. I. Viral forms. Biken’s J. 14, 177–190 (1971)

    Google Scholar 

  • Nn, S., Rosenkranz, H. S., Morgan, C., Rose, H. M.: Electron microscopy of herpes simplex virus. III. Effect of hydroxyurea. J. Virol. 2, 1163–1171 (1968)

    Google Scholar 

  • Onoda, T., Konobe, T., Takaku, K., Naito, M., Ono, K., Kato, S.: Temperature-sensitive growth of a herpes type virus isolated from a chicken with Marek’s disease. Biken’s J. 14, 357–360 (1971)

    CAS  Google Scholar 

  • Padgett, B. L., Tomkins, J.K.N.: Conditional lethal mutants of rabbit-pox virus. III. Temperature-sensitive (ts) mutants; physiological properties, complementation and recombination. Virology 36, 161–167 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Plummer, G., Goodheart, C. R., Hanson, D., Bowling, C. P.: A comparative study of the DNA density and behavior in tissue cultures of fourteen different herpesviruses. Virology 39, 134–137 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Pringle, C. R.: Genetic characteristics of conditional lethal mutants of vesicular stomatitis virus induced by 5-fluorouracil, 5-azacytidine and ethyl methane sulfonate. J. Virol. 5, 559–567 (1970)

    PubMed  CAS  Google Scholar 

  • Pringle, C. R., Howard, D. K., Hay, J.: Temperature-sensitive mutants of pseudorabies virus with differential effects on viral and host DNA synthesis. Virology 55, 495–505 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Purifoy, D. J. M., Benyesh-Melnick, M.: DNA polymerase induction by DNA~ temperature-sensitive (ts) mutants of herpes simplex virus type 2 (HSV-2). Abstracts Ann. Meet. Amer. Soc. Microbiol. V 201, 234 (1974)

    Google Scholar 

  • Rapp, F., Li, J.-L. H., Jerkofsky, M.: Transformation of mammalian cells by DNA-containing viruses following photodynamic inactivation. Virology 55, 339–346 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Rawls, W. E., Tompkins, W. A. F., Figueroa, M. E., Melnick, J.L.: Herpesvirus type 2: Association with carcinoma of the cervix. Science 161, 1255–1256 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Robb, J. A., Martin, R. G.: Genetic analysis of simian virus 40. I. Description of microtitration and replica-plating techniques for virus. Virology 41, 751–760 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Roizman, B.: The herpesviruses—A biochemical definition of the group. Curr. Topics Microbiol. Immunol. 49, 1–79 (1969)

    Google Scholar 

  • Roizman, B., Frenkel, N.: The transcription and state of herpes simplex virus DNA in productive infection and in human cervical cancer tissue. Cancer Res. 33, 1402–1416 (1973)

    PubMed  CAS  Google Scholar 

  • Roizman, B., Spear, P. G., Kieff, E. D.: Herpes simplex viruses I and II: A biochemical definition. Perspect. Virol. 8, 129–169 (1972)

    Google Scholar 

  • Roizman, B., et al.: Provisional labels for herpesviruses. Report of the Herpesvirus Study Group, International Committee for the Nomenclature of Viruses. J. gen. Virol. 20, 417–419 (1973)

    Article  Google Scholar 

  • Ross, L. J. N., Cameron, K. R., Wildy, P.: Ultraviolet irradiation of herpes simplex virus: Reactivation processes and delay in virus multiplication. J. gen. Virol. 16, 299–311 (1972b)

    Article  PubMed  CAS  Google Scholar 

  • Ross, L. J. N., Frazier, J. A., Biggs, P. M.: An antigen common to some avian and mammalian herpesviruses. In: Oncogenesis and herpesviruses, Biggs, P. M., de-The, G., Payne, L. N. (eds.). Lyon: Int. Agency Res. Cancer 1972A

    Google Scholar 

  • Russell, W. C., Crawford, L. V.: Properties of the nucleic acids from some herpes group viruses. Virology 22, 288–292 (1964)

    Article  PubMed  CAS  Google Scholar 

  • Savage, T., Roizman, B., Heine, J. W.: Immunological specificity of the glycoproteins of herpes simplex virus subtypes 1 and 2. J. gen. Virol. 17, 31–48 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Schaffer, P. A., Aron, G. M., Biswal, N., Benyesh-Melnick, M.: Temperature-sensitive mutants of herpes simplex virus type 1: Isolation, complementation and partial characterization. Virology 52, 57–71 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Schaffer, P. A., Brunschwig, J. P., Mccombs, R. M., Benyesh-Melnick, M.: Electron microscopic studies of temperature-sensitive mutants of herpes simplex virus type 1. Virology 62, 444–457 (1974b)

    Article  PubMed  CAS  Google Scholar 

  • Schaffer, P. A., Courtney, R. J., Mccombs, R. M., Benyesh-Melnick, M.: A temperature-sensitive mutant of herpes simplex virus defective in glycoprotein synthesis. Virology 46, 356–368 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Schaffer, P. A., Lam, K., Wimberly, I., Benyesh-Melnick, M.: Temperature-sensitive mutants of herpesvirus saimiri. Manuscript in preparation

    Google Scholar 

  • Schaffer, P. A., Tevethia, M. J., Benyesh-Melnick, M.: Recombination between temperature-sensitive mutants of herpes simplex virus type 1. Virology 58, 219–228 (1974a)

    Article  PubMed  CAS  Google Scholar 

  • Schaffer, P., Vonka, V., Lewis, R., Benyesh-Melnick, M.: Temperature-sensitive mutants of herpes simplex virus. Virology 42, 1144–1146 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Sheldrick, P., Laithier, M., Landò, D., Ryhiner, M. L.: Infectious DNA from herpes simplex virus: Infectivity of double-stranded and single-stranded molecules. Proc. nat. Acad. Sci. (Wash.) 70, 3621–3625 (1973)

    Article  CAS  Google Scholar 

  • Shiroki, K., Arisawa, J., Shimojo, H.: Isolation and a preliminary characterization of temperature-sensitive mutants of adenovirus 12. Virology 49, 1–11 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Sim, C., Watson, D. H.: The role of type-specific and cross-reacting structural antigens in the neutralization of herpes simplex virus types 1 and 2. J. gen. Virol. 19, 217–233 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Skare, J., Summers, W. T., Summers, W. C.: Structure and function of herpesvirus genomes. I. Comparison of five HSV-1 and two HSV-2 strains by cleavage of their DNA with Eco Ri restriction endonuclease. Submitted for publication

    Google Scholar 

  • Soehner, R. L., Gentry, G. A., Randall, C. C.: Some physicochemical characteristics of equine abortion virus nucleic acid. Virology 26, 394–405 (1965)

    Article  PubMed  CAS  Google Scholar 

  • Spear, P. G., Roizman, B.: Proteins specified by herpes simplex viruses. V. Purification and structural proteins of the herpesvirion. J. Virol. 9, 143–159 (1972)

    PubMed  CAS  Google Scholar 

  • Stephenson, J. R., Reynolds, R. K., Aaronson, S.A.: Isolation of temperature-sensitive mutants of murine leukemia virus. Virology 48, 749–756 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Subak-Sharpe, J. H.: Base doublet frequency patterns in the nucleic acid and evolution of viruses. Brit. med. Bull. 23, 161–168 (1967)

    CAS  Google Scholar 

  • Subak-Sharpe, J.H.: The genetics of herpesvirus. Cancer Res. 33, 1385–1392 (1973)

    PubMed  CAS  Google Scholar 

  • Subak-Sharpe, J. H., Brown, S. M., Ritchie, D. A., Timbury, M. C., Halliburton, I. W.: Herpes virus genetics. Advanc. Biosci. 11, 205–218 (1973)

    Google Scholar 

  • Tevethia, M. J., Ripper, L. W., Tevethia, S.S.: A simple qualitative spot complementation test for temperature-sensitive mutants of SV40. Intervirology, 3, 245–255 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Thouless, M. E.: Serological properties of thymidine kinase produced in cells infected with type 1 or type 2 herpesvirus. J. gen. Virol. 17, 307–315 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Timbury, M. C.: Temperature-sensitive mutants of herpes simplex virus type 2. J. gen. Virol. 13, 373–376 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Timbury, M. C., Subak-Sharpe, J. H.: Genetic interactions between temperature-sensitive mutants of types 1 and 2 herpes simplex viruses. J. gen. Virol. 18, 347–357 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Timbury, M. C., Theriault, A., Elton, R. A.: A stable syncytial mutant of herpes simplex type 2 virus. J. gen. Virol. 23, 219–224 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Tooze, J. (ed.): The molecular biology of tumour viruses. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory 1973

    Google Scholar 

  • Visconti, N., Delbrück, M.: The mechanism of genetic recombination in phage. Genetics 38, 5–33 (1953)

    PubMed  CAS  Google Scholar 

  • Wagner, E. K., Swanstrom, R. I., Stafford, M. G.: Transcription of the herpes simplex virus genome in human cells. J. Virol. 10, 675–682 (1972)

    PubMed  CAS  Google Scholar 

  • Wagner, E. K., Tewari, K. K., Kolodner, R., Warner, R. C.: The molecular size of herpes simplex virus type 1 genome. Virology 57, 436–447 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Watson, D. H., Wildy, P., Harvey, B. A. M., Shedden, W. I. H.: Serological relationships among the viruses of the herpes group. J. gen. Virol. 1, 139–141 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Wildy, P.: Recombination with herpes simplex virus. J. gen. Microbiol. 13, 34–46 (1955)

    Google Scholar 

  • Wildy, P.: Classification and nomenclature of viruses. Monogr. Virol. 5, 33–34 (1971)

    Google Scholar 

  • Wildy, P.: Herpes: History and classification. In: The herpesviruses, Kaplan, A. S. (ed.). New York and London: Academic Press 1973

    Google Scholar 

  • Wilkie, N. M.: The synthesis and substructure of herpesvirus DNA: The distribution of alkali-labile single strand interruptions in HSV-1 DNA. J. gen. Virol. 21, 453–467 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Wilkie, N.M., Ustacelebi, S., Williams, J. F.: Characterization of temperature sensitive mutants of adenovirus type 5-Nucleic acid synthesis. Virology 51, 499–503 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Witter, R. L., Nazerian, K., Purchase, H. G., Burgoyne, G. H.: Isolation from turkeys of a cell-associated herpesvirus antigenically related to Marek’s disease virus. Amer. J. vet. Res. 31, 525 (1970)

    PubMed  CAS  Google Scholar 

  • Zur Hausen, H., Schulte-Holthausen, H.: Presence of EB virus nucleic acid homology in a “virus-free” line of Burkitt tumour cells. Nature (Lond.) 227, 245–248 (1970)

    Article  Google Scholar 

  • Zygraich, N., Huygelen, C.: In vivo behavior of a temperature-sensitive (ts) mutant of herpesvirus hominis type 2. Arch. ges. Virusforsch. 43, 103–111 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Zygraich, N., Lobmann, M., Vascoboinic, E., Berge, E., Huygelen, C.: In vivo and in vitro properties of a temperature-sensitive mutant of infectious bovine rhino-tracheitis virus. Res. Vet. Sci., in press (1974b)

    Google Scholar 

  • Zygraich, N., Vascoboinic, E., Huygelen, C.: Replication of a temperature-sensitive mutant of infectious bovine rhinotracheitis virus in the tissues of inoculated calves. Zbl. Vet.-Med. 21, 138–144 (1974a)

    CAS  Google Scholar 

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Authors and Affiliations

  1. Dept. of Virology and Epidemiology, Baylor College of Medicine, Texas Medical Center, Houston, Texas, 77025, USA

    P. A. Schaffer

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  1. P. A. Schaffer
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  1. Basle, Switzerland

    W. Arber  & N. K. Jerne  & 

  2. Philadelphia, USA

    W. Henle , P. Koldovský  & H. Koprowski ,  & 

  3. Martinsried, Germany

    P. H. Hofschneider

  4. London, UK

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  5. Copenhagen, Denmark

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  6. Gießen, Germany

    R. Rott

  7. Wilhelmshaven, Germany

    H. G. Schweiger

  8. Rehovot, Israel

    M. Sela

  9. Prague, Czech Republic

    L. Syruček

  10. Seattle, USA

    P. K. Vogt

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© 1975 Springer-Verlag, Berlin · Heidelberg

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Schaffer, P.A. (1975). Temperature-Sensitive Mutants of Herpesviruses. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66101-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-66101-3_3

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