The Effects of Sodium Nitroprusside on Intracranial Pressure and Autoregulation
Sodium nitroprusside is being widely used for the production of hypotension in neurosurgery. KEANEY et al (1) have shown in animal investigations that after both halothane and sodium nitroprusside-induced hypotension, autoregulation of cerebral blood flow is impaired. There appears to be a partial recovery of autoregulation 90 minutes after hypotension induced with sodium nitroprusside, but not at this time after halothane-induced hypotension.
Key wordsSodium nitroprusside intraventricular pressure neurosurgery post-operative care autoregulation
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