Some Aspects of Cerebrovascular Resistance in Raised Intracranial Pressure: An Experimental Study

  • Lindsay Symon
  • H. Alan Crockard
  • Janos Juhasz


Observations on pressure waves occurring in the course of pathological states in man have indicated that, during increased intracranial pressure, intracranial pulsation is markedly increased (1,2,3). It seems probable, therefore, that during rising intracranial pressure, some abnormality of cerebrovascular resistance is present. This is further implied by the demonstration is previous experiments (4,5) that cerebral blood flow is maintained up to a point despite rising intracranial pressure. The present experiments were designed to determine the behaviour of the cerebrovascular resistance during experimentally raised intracranial pressure in the baboon.

Key words

Intracranial pressure pulse transmission cerebrovascular resistance pressure waves 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    LUNDBERG, N.: Continuous recording and control of ventricular fluid pressure in neurosurgical practice. Acta Psychiat. Scand. 36, suppl. 149 (1960).Google Scholar
  2. 2.
    CROCKARD, H.A., COPPEL, D.L., MORROW, W.F.K.: Evaluation of hyperventilation in the treatment of head injuries. Brit. Med. J. 4, 634–640 (1973).PubMedCrossRefGoogle Scholar
  3. 3.
    SYMON, L., DORSCH, N.W.C., STEPHENS, R.J.: Pressure waves in so-called low pressure hydrocephalus. Lancet ii, 1291–1292 (1972).CrossRefGoogle Scholar
  4. 4.
    HäGGENDAL, E., LöFGREN, J., NILSSON, N.J.: Die Gehirndurchblutung bei experimentellen Liquordruckänderungen. Verhandl. Int. Neurochirurgen Kongress, Bad Dürckheim, 1966.Google Scholar
  5. 5.
    SYMON, L., PáSZTOR, E., BRANSTON, N.M., DORSCH, N.W.C.: The effect of supratentorial space-occupying lesions on regional intracranial pressure and local cerebral blood flow. J. Neurol. Neurosurg. Psychiat. 37, 6, 617–626 (1974).PubMedCrossRefGoogle Scholar
  6. 6.
    PáSZTOR, E., SYMON, L., DORSCH, N.W.C., BRANSTON, N.M.: The hydrogen clearance method in assessment of blood flow in cortex, white matter, and deep nuclei of baboons. Stroke 4, 556–567 (1973).PubMedCrossRefGoogle Scholar
  7. 7.
    DORSCH, N.W.C., STEPHENS, R.J., SYMON, L.: An intracranial pressure transducer. Biomed. Eng. 6, 452–457 (1971).PubMedGoogle Scholar
  8. 8.
    SYMON, L., PáSZTOR, E., DORSCH, N.W.C., BRANSTON, N.M.: Physiological responses of local areas of cerebral circulation in experimental primates determined by the method of hydrogen clearance. Stroke 4, 632–642 (1973).PubMedCrossRefGoogle Scholar
  9. 9.
    LANGFITT, T.W., KASSEL, N.F., WEINSTEIN, J.D.: Cerebral blood flow with intracranial hypertension. Neurology (Minneap.) 15, 761–763 (1965).Google Scholar
  10. 10.
    STRANDGAARD, S., OLESEN, J., SKINHØJ, E., LASSEN, N.A.: Auto-regulation of brain circulation in severe arterial hypertension. Brit. Med. J. 1, 507–510 (1973).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1975

Authors and Affiliations

  • Lindsay Symon
  • H. Alan Crockard
  • Janos Juhasz

There are no affiliations available

Personalised recommendations