Effects of Intracranial Hypertension, Low-Pressure Hydrocephalus and Subsequent Ventriculo-Peritoneal Shunting on Monoamine Neurons in Rabbit Brain
Intracranial hypertension and hydrocephalus may produce functional disturbances in the brain which, to a certain extent, are manifested in neurological symptoms. The damage to the brain parenchyma can also be estimated in terms of alterations in certain biochemical parameters, but it is difficult to distinguish to which extent such alterations are associated with the neurons or with other components of the brain. More specifically, the neuronal injury can be studied by morphological approaches, either at the level of optical or electron microscopy. However, it should be born in mind that a neuronal impairment which is demonstrable by morphological techniques, has already reached a fairly advanced stage.
Key wordsKaolin intracracranial hypertension brain monomines ventriculoperitoneal shunting
Unable to display preview. Download preview PDF.
- 1.Björklund, A., Falck, B., Owman, C.: Fluorescence microscopic and microspectrofluorometric techniques for the cellular localization and characterization of biogenic amines. In: Berson, S.A. (ed.): Methods of Investigative and Diagnostic Endocrinology, vol. 1: Rall, J.E., Kopin, I.J. (eds): The Thyroid and Biogenic Amines, pp. 318–368. Amsterdam: North Holland Publ. Co. 1972.Google Scholar
- 3.Fuxe, K.: Evidence for the existence of monoamine neurons in the central nervous system. Thesis, Stockholm, pp. 1–35. Uppsala: Almqvist and Wiksell 1965.Google Scholar
- 4.Ungerstedt, U.: Stereotaxic mapping of the monoamine pathways in the rat brain. Acta physiol. scand., suppl. 367 (1971).Google Scholar
- 5.Lindvall, O., Björklund, A.: The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. Acta physiol. scand., suppl. 412 (1974).Google Scholar
- 11.Bertler, A., Carlsson, A., Rosengren, E., Waldeck, B.: A method for the fluorimetric determination of adrenaline, nor-adrenaline, and dopamine in tissues. Kungl. Fysiogr. Sällsk. Lund Förh. 28, 121–123 (1958).Google Scholar