A Compartmental Analysis of Compliance and Outflow Resistance and the Effects of Elevated Blood Pressure
Our studies of intracranial pressure dynamics have shown that the volume extensibility, or compliance, in combination with the resistance to drainage of CSF are major parameters which affect the rate of change and resting level of the ICP. The objective of this investigation was to examine how these parameters were distributed between cranial and spinal compartments. We hypothesized that in the cranial compartment, a shift of cerebral blood volume offers the only means of rapid compensation to sudden changes in CSF volume. A second objective, then, was to examine to what extent the compliance which would be affected by the degree of this vascular compensation, is influenced by changes in mean systemic blood pressure.
Key WordsCerebral spinal compliance CSF absorption
Unable to display preview. Download preview PDF.